KEGG   PATHWAY: mjv04062
Entry
mjv04062                    Pathway                                
Name
Chemokine signaling pathway - Manis javanica (Malayan pangolin)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
mjv04062  Chemokine signaling pathway
mjv04062

Other DBs
GO: 0070098
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383250  RHOA; transforming protein RhoA [KO:K04513]
108383520  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108383754  [KO:K05408]
108383755  [KO:K12964]
108383756  [KO:K05408]
108383886  CCR9; C-C chemokine receptor type 9 [KO:K04184]
108383888  XCR1; chemokine XC receptor 1 [KO:K04193]
108383891  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
108384279  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108385086  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108386067  CCR10; C-C chemokine receptor type 10 [KO:K04185]
108386068  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108386155  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
108386386  [KO:K16596]
108386387  [KO:K16595]
108386389  [KO:K16597]
108386490  CCR6; C-C chemokine receptor type 6 [KO:K04181]
108386548  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
108386551  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
108386580  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108386690  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
108387037  GRK3; G protein-coupled receptor kinase 3 isoform X1 [KO:K00910] [EC:2.7.11.15]
108387059  CCR7; C-C chemokine receptor type 7 [KO:K04182]
108387357  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
108387368  [KO:K05050]
108387546  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
108387830  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108387898  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
108388002  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108388194  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108388330  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
108388509  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
108388549  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108389003  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108389764  [KO:K14624]
108389875  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
108390100  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
108390150  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390671  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
108391039  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
108391050  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
108391240  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
108391302  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.39]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108391706  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108391745  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
108391894  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
108392468  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
108392664  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108393151  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
108393262  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108393369  GSK3A; glycogen synthase kinase-3 alpha isoform X1 [KO:K08822] [EC:2.7.11.26]
108393599  CCL26; C-C motif chemokine 26 [KO:K21096]
108393600  CCL24; C-C motif chemokine 24 isoform X2 [KO:K21097]
108393633  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108394257  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X5 [KO:K05858] [EC:3.1.4.11]
108394259  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108394280  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108394326  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108394387  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
108394533  CRK; adapter molecule crk isoform X1 [KO:K04438]
108394631  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108395188  PARD3; partitioning defective 3 homolog isoform X8 [KO:K04237]
108395258  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
108395333  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
108395349  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
108395358  [KO:K16598]
108395366  CCL19; C-C motif chemokine 19 [KO:K05512]
108395444  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
108395546  RAP1A; ras-related protein Rap-1A [KO:K04353]
108395594  CCL21; C-C motif chemokine 21 isoform X2 [KO:K16062]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108395975  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
108396051  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
108396111  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
108396170  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
108396202  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
108396371  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
108396721  ADCY5; adenylate cyclase type 5 isoform X4 [KO:K08045] [EC:4.6.1.1]
108397005  RELA; transcription factor p65 isoform X1 [KO:K04735]
108397041  [KO:K04634]
108397287  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
108397345  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108397669  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108397673  [KO:K05505]
108397691  PXN; paxillin isoform X1 [KO:K05760]
108398047  NRAS; GTPase NRas [KO:K07828]
108398173  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
108398401  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
108398403  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108398727  [KO:K10030]
108399351  [KO:K05507]
108399649  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
108399795  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108399960  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
108400080  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
108400464  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108400628  [KO:K04177]
108400629  CCR5; C-C chemokine receptor type 5 [KO:K04180]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108400663  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
108400819  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108400940  CCR3; C-C chemokine receptor type 3 [KO:K04178]
108400941  CCR1; C-C chemokine receptor type 1 [KO:K04176]
108400984  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
108401250  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
108401471  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
108401472  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108401653  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108401794  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108402236  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108402352  SHC4; SHC-transforming protein 4 [KO:K17449]
108402523  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108402874  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
108403056  CXCL13; C-X-C motif chemokine 13 isoform X1 [KO:K10032]
108403336  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
108403337  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
108403511  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108403551  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
108403664  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
108404560  [KO:K10031]
108404851  CX3CL1; fractalkine isoform X1 [KO:K05508]
108404891  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108405031  CXCR3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
108405278  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
108406129  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108406370  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
108406440  CXCL8; interleukin-8 isoform X1 [KO:K10030]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108406782  CCR4; C-C chemokine receptor type 4 [KO:K04179]
108406917  CX3CR1; CX3C chemokine receptor 1 isoform X5 [KO:K04192]
108407248  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
108407280  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
108407296  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
108407356  RAP1B; ras-related protein Rap-1b [KO:K07836]
108407505  CCL5; C-C motif chemokine 5 [KO:K12499]
108407513  CCL15; C-C motif chemokine 15 [KO:K05511]
108407514  CCL16; C-C motif chemokine 16 [KO:K21093]
108407569  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108408250  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
108408298  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108408402  WAS; actin nucleation-promoting factor WAS isoform X3 [KO:K05747]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
108408988  CRKL; crk-like protein [KO:K04438]
108409101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
108409197  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
108409379  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
108409508  PPBP; platelet basic protein [KO:K10029]
108409509  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
108409510  [KO:K05407]
108409586  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108409661  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
108409724  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108410067  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
108410207  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118967667  [KO:K02833]
118968537  [KO:K05854] [EC:2.7.10.2]
118969284  [KO:K05505]
118974145  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
140842982  [KO:K02833]
140843067  [KO:K02833]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
mjv04010  MAPK signaling pathway
mjv04060  Cytokine-cytokine receptor interaction
mjv04120  Ubiquitin mediated proteolysis
mjv04630  JAK-STAT signaling pathway
mjv04670  Leukocyte transendothelial migration
mjv04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

DBGET integrated database retrieval system