KEGG   PATHWAY: ecb04015
Entry
ecb04015                    Pathway                                
Name
Rap1 signaling pathway - Equus caballus (horse)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04015  Rap1 signaling pathway
ecb04015

Other DBs
GO: 0007264
Organism
Equus caballus (horse) [GN:ecb]
Gene
100009697  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100009704  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100033956  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100033957  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
100033959  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100033960  FGF1; fibroblast growth factor 1 [KO:K18496]
100033961  FGF7; fibroblast growth factor 7 [KO:K04358]
100034039  ADORA2A; adenosine receptor A2a [KO:K04266]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100034127  KITLG; kit ligand precursor [KO:K05461]
100034198  IGF1; insulin-like growth factor I precursor [KO:K05459]
100049816  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14 [KO:K05631]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100049905  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
100049912  [KO:K04353]
100049969  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X2 [KO:K17701]
100050037  FGF20; fibroblast growth factor 20 [KO:K04358]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100050353  FGF9; fibroblast growth factor 9 [KO:K04358]
100050541  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
100050675  [KO:K04632]
100050855  CRKL; crk-like protein [KO:K04438]
100050877  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100050998  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
100051000  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100051221  FGF6; fibroblast growth factor 6 [KO:K04358]
100051282  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100051329  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100051349  PGF; placenta growth factor isoform X1 [KO:K16859]
100051360  RALA; ras-related protein Ral-A [KO:K07834]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100051785  [KO:K07827]
100051890  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100052025  RAP1B; ras-related protein Rap-1b [KO:K07836]
100052122  [KO:K02649]
100052187  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100052576  [KO:K08732]
100052655  FGF10; fibroblast growth factor 10 [KO:K04358]
100052764  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100052775  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100052798  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100053056  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100053411  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100053481  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100053644  EPHA2; ephrin type-A receptor 2 isoform X3 [KO:K05103] [EC:2.7.10.1]
100053797  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100054133  TLN2; talin-2 isoform X1 [KO:K06271]
100054137  [KO:K08732]
100054187  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100054542  FGF21; fibroblast growth factor 21 [KO:K22429]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100054846  AFDN; afadin isoform X1 [KO:K05702]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100054964  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100055238  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100055241  CTNNB1; catenin beta-1 [KO:K02105]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100055494  P2RY1; P2Y purinoceptor 1 isoform X1 [KO:K04270]
100055501  TLN1; talin-1 isoform X3 [KO:K06271]
100055673  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100055674  DOCK4; dedicator of cytokinesis protein 4 isoform X2 [KO:K17697]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100055781  RRAS; ras-related protein R-Ras [KO:K07829]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100056032  [KO:K08732]
100056049  [KO:K06464]
100056128  ITGB2; integrin beta-2 [KO:K06464]
100056163  PFN4; profilin-4 isoform X1 [KO:K05759]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056444  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
100056464  [KO:K04632]
100056482  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100056814  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100057133  CALML5; calmodulin-like protein 5 [KO:K02183]
100057186  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100057358  ENAH; protein enabled homolog isoform X7 [KO:K05746]
100057444  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
100057478  THBS1; thrombospondin-1 precursor [KO:K16857]
100057614  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100058238  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100058460  FGF23; fibroblast growth factor 23 [KO:K22428]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100058930  RAP1A; ras-related protein Rap-1A [KO:K04353]
100059274  LCP2; lymphocyte cytosolic protein 2 isoform X2 [KO:K07361]
100059469  NRAS; GTPase NRas [KO:K07828]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100059861  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100060169  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
100060199  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
100060218  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100060219  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100060309  FGF8; fibroblast growth factor 8 [KO:K04358]
100060422  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
100060488  FGF19; fibroblast growth factor 19 [KO:K22603]
100060525  FGF4; fibroblast growth factor 4 [KO:K04358]
100060890  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061295  PFN1; profilin-1 [KO:K05759]
100061488  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100061676  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100062015  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100062085  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100062195  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100062752  CALM1; calmodulin-1 [KO:K02183]
100063136  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100063240  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100063307  EFNA1; ephrin-A1 [KO:K05462]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100063319  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
100063392  RAPGEF6; rap guanine nucleotide exchange factor 6 [KO:K08020]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100063737  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100063746  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100063871  [KO:K08732]
100063981  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
100064121  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
100064240  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
100064430  LAT; linker for activation of T-cells family member 1 [KO:K07362]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100064482  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100064709  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X3 [KO:K06112]
100064781  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100064803  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100065508  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
100065539  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100065587  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100065669  NGF; beta-nerve growth factor [KO:K02582]
100065681  CNR1; cannabinoid receptor 1 [KO:K04277]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100065866  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100066248  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100066754  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
100066773  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100066844  CDH1; cadherin-1 [KO:K05689]
100066963  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100067065  CTNND1; catenin delta-1 isoform X2 [KO:K05690]
100067593  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
100067721  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100067818  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100068419  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100068605  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
100068679  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
100068908  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100069003  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X14 [KO:K08018]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100069371  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
100069402  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100069527  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X8 [KO:K06277]
100069694  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100069950  F2RL3; proteinase-activated receptor 4 [KO:K04236]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100070422  [KO:K02183]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100070505  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100070545  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100070851  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100071150  CALM3; calmodulin-3 [KO:K02183]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100071716  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
100071749  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100071790  FGF16; fibroblast growth factor 16 [KO:K04358]
100072169  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100072461  FGF22; fibroblast growth factor 22 [KO:K04358]
100073202  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100073278  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100146493  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100146649  FGF3; fibroblast growth factor 3 [KO:K04358]
100146754  PFN3; profilin-3 [KO:K05759]
100147585  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100629145  CALM2; calmodulin-2 [KO:K02183]
100629648  FGF18; fibroblast growth factor 18 [KO:K04358]
100630364  PFN2; profilin-2 isoform X1 [KO:K05759]
102147367  [KO:K08732]
102147510  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102148588  [KO:K08732]
102148861  [KO:K05759]
102149317  [KO:K08732]
102149416  [KO:K08732]
102149785  [KO:K08732]
102150244  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102150685  [KO:K08732]
106780978  [KO:K08732]
106781089  [KO:K08732]
106781151  [KO:K08732]
106781162  [KO:K08732]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
106783094  [KO:K10785]
111772100  [KO:K10784]
111774429  EFNA2; ephrin-A2 [KO:K05462]
111776000  INS; insulin [KO:K04526]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
ecb04010  MAPK signaling pathway
ecb04014  Ras signaling pathway
ecb04020  Calcium signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04510  Focal adhesion
ecb04520  Adherens junction
ecb04660  T cell receptor signaling pathway
ecb04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

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