KEGG   PATHWAY: ecb04024
Entry
ecb04024                    Pathway                                
Name
cAMP signaling pathway - Equus caballus (horse)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04024  cAMP signaling pathway
ecb04024

Other DBs
GO: 0019933
Organism
Equus caballus (horse) [GN:ecb]
Gene
100009680  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
100009683  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
100009689  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
100033829  FSHB; follitropin subunit beta precursor [KO:K05250]
100033847  EDN2; endothelin-2 precursor [KO:K16367]
100033908  SOX9; transcription factor SOX-9 [KO:K18435]
100033936  PTCH1; protein patched homolog 1 [KO:K06225]
100033937  GLI1; zinc finger protein GLI1 [KO:K16797]
100033968  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100034039  ADORA2A; adenosine receptor A2a [KO:K04266]
100034043  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
100034053  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100034060  EDN1; endothelin-1 precursor [KO:K16366]
100034064  EDN3; endothelin-3 isoform X1 [KO:K05227]
100034065  TNNI3; troponin I, cardiac muscle [KO:K12044]
100034081  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
100034086  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
100034092  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100034139  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 precursor [KO:K01539] [EC:7.2.2.13]
100034174  CGA; glycoprotein hormones alpha chain precursor [KO:K08522]
100034188  TSHB; thyrotropin subunit beta precursor [KO:K05251]
100034201  NPPA; natriuretic peptides A preproprotein [KO:K12334]
100049840  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
100049912  [KO:K04353]
100049920  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100049924  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100050114  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100050311  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100050431  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
100050541  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
100050675  [KO:K04632]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100051186  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100051329  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100051344  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
100051466  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
100051551  GCG; glucagon isoform X1 [KO:K05259]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100051636  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051886  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
100052025  RAP1B; ras-related protein Rap-1b [KO:K07836]
100052122  [KO:K02649]
100052410  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
100052496  ADORA1; adenosine receptor A1 [KO:K04265]
100052603  TSHR; thyrotropin receptor [KO:K04249]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100052744  SSTR2; somatostatin receptor type 2 [KO:K04218]
100052764  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100052798  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100052957  FSHR; follicle-stimulating hormone receptor precursor [KO:K04247]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100053557  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
100053806  NPY; pro-neuropeptide Y [KO:K05232]
100053961  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100054385  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
100054460  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100054774  LHB; lutropin/choriogonadotropin subunit beta precursor [KO:K08521]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100054846  AFDN; afadin isoform X1 [KO:K05702]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100055029  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
100055033  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
100055136  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100055199  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100055231  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100055470  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
100055626  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100055673  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100055781  RRAS; ras-related protein R-Ras [KO:K07829]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100056372  SUCNR1; succinate receptor 1 [KO:K10042]
100056464  [KO:K04632]
100056690  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
100056933  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100057018  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
100057133  CALML5; calmodulin-like protein 5 [KO:K02183]
100057396  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
100057437  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
100057483  RELA; transcription factor p65 [KO:K04735]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100057711  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100057774  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100057865  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100058008  GHRL; appetite-regulating hormone [KO:K05254]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058238  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100058251  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100058301  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
100058656  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100058846  DRD1; D(1A) dopamine receptor [KO:K04144]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100058930  RAP1A; ras-related protein Rap-1A [KO:K04353]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059449  [KO:K04328]
100059610  SST; somatostatin [KO:K05237]
100059726  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100059861  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100060020  GRIA1; glutamate receptor 1 isoform X4 [KO:K05197]
100060155  VIP; VIP peptides [KO:K05264]
100060276  SSTR1; somatostatin receptor type 1 [KO:K04217]
100060366  HCAR2; hydroxycarboxylic acid receptor 2 [KO:K08402]
100060403  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
100060501  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100060659  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061333  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
100061356  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
100061553  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
100061561  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
100061676  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
100061686  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100061959  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
100062085  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100062195  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100062644  EDNRA; endothelin-1 receptor precursor [KO:K04197]
100062752  CALM1; calmodulin-1 [KO:K02183]
100062786  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
100062861  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100062868  HHIP; hedgehog-interacting protein isoform X2 [KO:K06231]
100062895  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100062954  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100063001  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100063217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100063746  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100063840  CRH; corticoliberin [KO:K05256]
100063963  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
100064098  GLI3; transcriptional activator GLI3 isoform X3 [KO:K06230]
100064117  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100064121  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
100064138  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13 [KO:K04515] [EC:2.7.11.17]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100064403  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100064482  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100064906  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100065307  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100065574  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
100065598  CRHR1; corticotropin-releasing factor receptor 1 [KO:K04578]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100066125  [KO:K11265] [EC:4.6.1.1]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100066283  BVES; blood vessel epicardial substance [KO:K21108]
100066315  POPDC3; popeye domain-containing protein 3 [KO:K26207]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100067279  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100067398  SSTR5; somatostatin receptor type 5 [KO:K04221]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100068204  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X2 [KO:K15494]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100069276  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
100069331  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
100069563  GIP; gastric inhibitory polypeptide isoform X1 [KO:K05258]
100069598  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
100069604  DRD5; D(1B) dopamine receptor [KO:K05840]
100069613  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100069796  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
100069948  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
100070422  [KO:K02183]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100070899  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
100070901  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
100070959  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100070977  POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100071150  CALM3; calmodulin-3 [KO:K02183]
100071259  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100071524  POMC; pro-opiomelanocortin [KO:K05228]
100071586  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100071615  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
100071630  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
100071654  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100072169  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
100072550  [KO:K05250]
100072618  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6 [KO:K04515] [EC:2.7.11.17]
100072684  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4 [KO:K05853] [EC:7.2.2.10]
100072863  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100073014  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
100073192  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100073278  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100146368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100146832  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100147080  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
100147281  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
100629145  CALM2; calmodulin-2 [KO:K02183]
100629801  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
100630668  PLN; cardiac phospholamban [KO:K05852]
100630886  FXYD1; phospholemman isoform X4 [KO:K13360]
102148318  AMH; muellerian-inhibiting factor precursor [KO:K04665]
102148904  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
106781784  OXTR; oxytocin receptor [KO:K04229]
111767489  OXT; oxytocin-neurophysin 1 [KO:K05243]
111769596  [KO:K04259]
111770367  TSHR; thyrotropin receptor [KO:K04249]
111772111  [KO:K04249]
111774151  HCN2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
111774159  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
111775964  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
791242  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
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Related
pathway
ecb00071  Fatty acid degradation
ecb04015  Rap1 signaling pathway
ecb04020  Calcium signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04210  Apoptosis
ecb04260  Cardiac muscle contraction
ecb04340  Hedgehog signaling pathway
ecb04720  Long-term potentiation
ecb04740  Olfactory transduction
ecb04972  Pancreatic secretion
ecb04976  Bile secretion
KO pathway
ko04024   

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