KEGG   PATHWAY: efus04621
Entry
efus04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Eptesicus fuscus (big brown bat)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
efus04621  NOD-like receptor signaling pathway
efus04621

Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103291550  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
103301859  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103284340  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
103301979  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103303246  IL1B; interleukin-1 beta [KO:K04519]
103293786  IL18; interleukin-18 isoform X1 [KO:K05482]
103292051  IL6; interleukin-6 [KO:K05405]
103300478  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129150475  interleukin-8-like [KO:K10030]
129150773  CXCL8; interleukin-8 [KO:K10030]
129151883  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
103288017  growth-regulated protein homolog gamma-like [KO:K05505]
103288018  growth-regulated protein homolog gamma-like [KO:K05505]
103291683  C-C motif chemokine 2 [KO:K14624]
103297029  CCL5; C-C motif chemokine 5 [KO:K12499]
103299036  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
103304244  beta-defensin 103A-like [KO:K23126]
103295893  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
103293777  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103288851  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103302357  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103297850  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103295508  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
103298650  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103298707  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103295577  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103284067  JUN; transcription factor Jun [KO:K04448]
103283205  ATG16L1; autophagy-related protein 16-1 isoform X2 [KO:K17890]
103298341  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
103288780  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
103284380  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
103285084  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
103296928  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
129150724  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
129151270  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
103284438  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X2 [KO:K10435]
103293359  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
129151762  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
103289645  SUGT1; protein SGT1 homolog [KO:K12795]
103302699  sharpin [KO:K20894]
103285594  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
103301488  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
103301896  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
103298826  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
103305159  ERBIN; erbin isoform X2 [KO:K12796]
103292960  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103292961  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103295968  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103290060  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
103290874  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103295984  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
103305243  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
103285642  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
103301807  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
103292497  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103297481  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103283376  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
103297623  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103302547  IRF7; interferon regulatory factor 7 [KO:K09447]
103289195  IFNB1; interferon beta [KO:K05415]
103293715  NLRX1; NLR family member X1 [KO:K12653]
103287908  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
103291462  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
103299921  LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
114228125  LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 1-like [KO:K12798]
103296229  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
103299256  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
103285583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103294360  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
103295113  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
103292935  PANX1; pannexin-1 [KO:K03443]
103287033  P2X purinoceptor 7 [KO:K05220]
129148056  P2X purinoceptor 7-like [KO:K05220]
129148148  P2X purinoceptor 7-like [KO:K05220]
103289778  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
103287424  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
103299408  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
103290741  CASR; extracellular calcium-sensing receptor isoform X2 [KO:K04612]
103283680  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
103302044  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103287505  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103285666  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
103285667  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103300420  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103285158  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103303043  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103286741  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103289448  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
103287362  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
103288183  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
103289479  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
103293910  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
103287239  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
129148092  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
103287240  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103290117  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
103299869  DHX33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
103286751  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
103295334  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
103302882  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
103301469  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
103285190  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
103293609  NAMPT; nicotinamide phosphoribosyltransferase isoform X1 [KO:K03462] [EC:2.4.2.12]
103302501  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103284449  cytochrome b-245 light chain [KO:K08009]
103296536  TXNIP; thioredoxin-interacting protein [KO:K20910]
103286353  TXN; thioredoxin [KO:K03671]
103288906  TXN2; thioredoxin, mitochondrial [KO:K03671]
103301652  thioredoxin-like [KO:K03671]
103298793  thioredoxin, mitochondrial-like [KO:K03671]
103304425  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
103302494  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X3 [KO:K11864] [EC:3.4.19.-]
103296621  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103298031  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
129150636  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
103296228  PYDC1; pyrin domain-containing protein 1 isoform X1 [KO:K12802]
103286324  MEFV; pyrin isoform X1 [KO:K12803]
103303877  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X3 [KO:K12804]
103290541  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103291049  FADD; FAS-associated death domain protein [KO:K02373]
103303784  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
103302590  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
103303389  NACHT, LRR and PYD domains-containing protein 2 [KO:K20864]
103303686  NLRP12; NACHT, LRR and PYD domains-containing protein 12 [KO:K20865]
103305174  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
103305480  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
103290422  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
103298004  GBP5; guanylate-binding protein 5 [KO:K20898]
103287363  TP53BP1; TP53-binding protein 1 [KO:K20915]
103298865  RHOA; transforming protein RhoA [KO:K04513]
103295254  transforming protein RhoA-like [KO:K04513]
103300985  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
103300870  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
103291757  YWHAE; 14-3-3 protein epsilon [KO:K06630]
129147113  LOW QUALITY PROTEIN: guanylate-binding protein 7-like [KO:K20899]
129150181  guanylate-binding protein 1-like [KO:K20899]
103300874  guanylate-binding protein 1 [KO:K20899]
103304270  guanylate-binding protein 4-like [KO:K20899]
129150297  guanylate-binding protein 1-like [KO:K20899]
103304392  guanylate-binding protein 1-like [KO:K20899]
114229937  guanylate-binding protein 1-like [KO:K20899]
129150299  guanylate-binding protein 4-like [KO:K20899]
103304272  LOW QUALITY PROTEIN: guanylate-binding protein 4-like [KO:K20899]
103304268  guanylate-binding protein 7-like [KO:K20899]
103303785  caspase-1-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
114227918  caspase-1-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
103299257  caspase-13-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
103302716  GSDMD; gasdermin-D isoform X1 [KO:K20917]
103289928  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103289837  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103284092  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103301133  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
103290572  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103292429  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103301487  IRF9; interferon regulatory factor 9 [KO:K04693]
103295671  TLR4; toll-like receptor 4 [KO:K10160]
103294388  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103298161  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103285212  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
103286123  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
efus04010  MAPK signaling pathway
efus04064  NF-kappa B signaling pathway
efus04140  Autophagy - animal
efus04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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