KEGG   PATHWAY: fpg04010
Entry
fpg04010                    Pathway                                
Name
MAPK signaling pathway - Falco peregrinus (peregrine falcon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
fpg04010  MAPK signaling pathway
fpg04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Falco peregrinus (peregrine falcon) [GN:fpg]
Gene
101910328  PDGFD; platelet derived growth factor D [KO:K05450]
101910414  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101910509  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
101910521  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101910610  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
101910639  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
101910755  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
101910888  CACNG7; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101910897  MAX; MYC associated factor X [KO:K04453]
101910950  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
101910975  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101911148  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
101911178  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101911197  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101911235  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101911268  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
101911376  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
101911552  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101911631  NGFR; nerve growth factor receptor [KO:K02583]
101911650  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
101911698  ANGPT2; angiopoietin 2 [KO:K05466]
101911760  FAS; Fas cell surface death receptor [KO:K04390]
101911761  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101911850  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
101911870  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
101911904  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
101911961  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
101911978  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
101911986  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101912003  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
101912007  [KO:K04386]
101912011  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
101912040  ATF2; activating transcription factor 2 [KO:K04450]
101912084  VEGFD; vascular endothelial growth factor D [KO:K05449]
101912281  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
101912446  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101912452  MEF2C; myocyte enhancer factor 2C [KO:K04454]
101912496  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
101912626  VEGFC; vascular endothelial growth factor C [KO:K05449]
101912650  TGFB3; transforming growth factor beta 3 [KO:K13377]
101912679  [KO:K04464] [EC:2.7.11.24]
101912795  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
101913074  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
101913240  ELK4; ELK4, ETS transcription factor [KO:K04376]
101913316  [KO:K05096] [EC:2.7.10.1]
101913355  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
101913384  VEGFA; vascular endothelial growth factor A [KO:K05448]
101913531  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101913671  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101913692  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101913726  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
101913846  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
101913890  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
101913969  GRB2; growth factor receptor bound protein 2 [KO:K04364]
101913992  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
101914093  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101914106  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
101914167  STK4; serine/threonine kinase 4 [KO:K04411]
101914322  FGF18; fibroblast growth factor 18 [KO:K04358]
101914347  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101914383  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
101914421  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101914455  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
101914611  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101914647  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101914651  KITLG; KIT ligand [KO:K05461]
101914699  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
101914715  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101914764  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
101914805  ECSIT; ECSIT signalling integrator [KO:K04405]
101914815  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101914877  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
101914879  CDC42; cell division cycle 42 [KO:K04393]
101914938  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
101915014  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
101915028  PDGFC; platelet derived growth factor C [KO:K05450]
101915107  FGF3; fibroblast growth factor 3 [KO:K04358]
101915163  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
101915262  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04863]
101915280  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101915315  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
101915745  INS; insulin [KO:K04526]
101915778  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
101915779  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
101915808  RASA1; RAS p21 protein activator 1 [KO:K04352]
101915910  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
101915916  IGF2; insulin like growth factor 2 [KO:K13769]
101916006  FGF17; fibroblast growth factor 17 [KO:K04358]
101916013  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
101916106  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
101916153  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
101916160  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
101916268  FGF20; fibroblast growth factor 20 [KO:K04358]
101916440  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101916621  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
101916622  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
101916694  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
101916827  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101916879  EGF; epidermal growth factor [KO:K04357]
101916982  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
101917007  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
101917138  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101917175  EFNA2; ephrin A2 [KO:K05462]
101917184  HGF; hepatocyte growth factor [KO:K05460]
101917220  SNRPG; small nuclear ribonucleoprotein polypeptide G [KO:K08774]
101917262  GNA12; G protein subunit alpha 12 [KO:K04346]
101917291  ARTN; artemin [KO:K25415]
101917357  TGFB2; transforming growth factor beta 2 [KO:K13376]
101917369  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
101917376  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
101917506  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
101917525  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
101917569  STMN1; stathmin 1 [KO:K04381]
101917721  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101917722  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101917746  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101917762  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
101917866  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101917881  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
101918017  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
101918084  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
101918148  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101918161  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101918253  FGF2; fibroblast growth factor 2 [KO:K18497]
101918260  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101918269  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
101918292  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
101918361  NRTN; neurturin [KO:K25414]
101918438  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101918536  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
101918542  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
101918580  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101918590  GNG12; G protein subunit gamma 12 [KO:K04347]
101918709  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
101918748  FGF16; fibroblast growth factor 16 [KO:K04358]
101918818  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
101918846  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101918868  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101918873  CSF1; colony stimulating factor 1 [KO:K05453]
101918910  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101918928  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
101919005  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
101919073  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101919170  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101919186  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101919264  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
101919267  SRF; serum response factor [KO:K04378]
101919271  EREG; epiregulin [KO:K09784]
101919319  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
101919417  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
101919443  AREG; amphiregulin [KO:K09782]
101919448  MRAS; muscle RAS oncogene homolog [KO:K07831]
101919573  ARRB1; arrestin beta 1 [KO:K04439]
101919634  STK3; serine/threonine kinase 3 [KO:K04412]
101919653  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
101919673  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
101919762  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101919998  FGF6; fibroblast growth factor 6 [KO:K04358]
101920008  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
101920011  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101920039  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
101920043  [KO:K16342] [EC:3.1.1.4]
101920129  FGF22; fibroblast growth factor 22 [KO:K04358]
101920170  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101920171  FGF23; fibroblast growth factor 23 [KO:K22428]
101920218  NGF; nerve growth factor [KO:K02582]
101920246  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
101920293  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
101920297  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
101920300  EFNA3; ephrin A3 [KO:K05462]
101920320  FGF5; fibroblast growth factor 5 [KO:K04358]
101920342  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
101920353  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101920477  EFNA1; ephrin A1 [KO:K05462]
101920542  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
101920584  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
101920660  ANGPT4; angiopoietin 4 [KO:K05467]
101920675  PGF; placental growth factor [KO:K16859]
101920743  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
101920747  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101920758  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
101920861  PDGFB; platelet derived growth factor subunit B [KO:K17386]
101920877  BDNF; brain derived neurotrophic factor [KO:K04355]
101921035  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
101921040  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101921076  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101921205  EFNA5; ephrin A5 [KO:K05462]
101921207  NF1; neurofibromin 1 [KO:K08052]
101921213  NTF3; neurotrophin 3 [KO:K04356]
101921306  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101921462  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101921486  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
101921498  TRADD; TNFRSF1A associated via death domain [KO:K03171]
101921590  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
101921607  GDNF; glial cell derived neurotrophic factor [KO:K05452]
101921612  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
101921635  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101921708  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
101921723  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101921803  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101921834  ATF4; activating transcription factor 4 [KO:K04374]
101921871  FGF10; fibroblast growth factor 10 [KO:K04358]
101921995  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
101922036  FASLG; Fas ligand [KO:K04389]
101922044  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101922058  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
101922064  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101922071  [KO:K04853]
101922121  [KO:K16342] [EC:3.1.1.4]
101922216  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
101922280  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
101922288  ANGPT1; angiopoietin 1 [KO:K05465]
101922378  FGF7; fibroblast growth factor 7 [KO:K04358]
101922433  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101922474  FGF1; fibroblast growth factor 1 [KO:K18496]
101922505  PDGFA; platelet derived growth factor subunit A [KO:K04359]
101922518  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
101922526  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
101922554  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
101922643  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101922655  IGF1; insulin like growth factor 1 [KO:K05459]
101922767  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101922782  FGF8; fibroblast growth factor 8 [KO:K04358]
101922907  MYD88; myeloid differentiation primary response 88 [KO:K04729]
101922961  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
101923101  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
101923251  [KO:K04421] [EC:2.7.11.25]
101923355  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
101923358  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
101923425  NRK; Nik related kinase [KO:K04407] [EC:2.7.11.1]
101923426  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
101923451  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
101923535  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
101923561  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
101923584  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101923629  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
101923673  FGF9; fibroblast growth factor 9 [KO:K04358]
101923999  RASA2; RAS p21 protein activator 2 [KO:K08053]
101924077  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
101924129  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101924165  MAPT; microtubule associated protein tau [KO:K04380]
101924219  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101924233  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
101924267  [KO:K04519]
101924296  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101924298  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
101924328  [KO:K04388] [EC:2.7.11.30]
101924364  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
101924556  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
101924559  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
101924613  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
101924845  [KO:K16342] [EC:3.1.1.4]
101924998  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101925011  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101925028  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
fpg04070  Phosphatidylinositol signaling system
fpg04110  Cell cycle
fpg04115  p53 signaling pathway
fpg04210  Apoptosis
fpg04310  Wnt signaling pathway
KO pathway
ko04010   

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