KEGG   PATHWAY: hgl04810
Entry
hgl04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Heterocephalus glaber (naked mole-rat)
Class
Cellular Processes; Cell motility
Pathway map
hgl04810  Regulation of actin cytoskeleton
hgl04810

Other DBs
GO: 0030036
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101696501  C8b; complement C8 beta chain [KO:K03998]
101696570  Actr3b; ARP3 actin related protein 3 homolog B [KO:K18584]
101696768  Pdgfd; platelet derived growth factor D [KO:K05450]
101697109  C8a; complement C8 alpha chain [KO:K03997]
101697197  Pak5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
101697313  Itgb4; integrin subunit beta 4 [KO:K06525]
101697360  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101697421  Gna12; G protein subunit alpha 12 [KO:K04346]
101697688  Baiap2; BAI1 associated protein 2 [KO:K05627]
101697884  Myl12b; myosin light chain 12B [KO:K12757]
101698044  Ppp1cb; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
101698063  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
101698311  Myl10; myosin light chain 10 [KO:K12756]
101698404  Itgad; integrin alpha-D [KO:K06594]
101698555  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101698820  Rgcc; regulator of cell cycle [KO:K26108]
101698830  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
101699189  Apc2; APC2, WNT signaling pathway regulator [KO:K02085]
101699254  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
101699399  Itga3; integrin subunit alpha 3 [KO:K06482]
101699438  Fgf8; fibroblast growth factor 8 [KO:K04358]
101699975  Git1; GIT ArfGAP 1 [KO:K05737]
101700150  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
101700214  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101700245  Arhgef6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
101700281  Fgf5; fibroblast growth factor 5 [KO:K04358]
101700282  [KO:K05762]
101700324  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101700388  Vav1; vav guanine nucleotide exchange factor 1 [KO:K05730]
101700594  Wasl; Wiskott-Aldrich syndrome like [KO:K23612]
101700633  Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
101700695  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101700702  Fam49b; family with sequence similarity 49 member B [KO:K27976]
101701226  Pxn; paxillin [KO:K05760]
101701289  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101701374  Cdc42; cell division cycle 42 [KO:K04393]
101701530  Fgf9; fibroblast growth factor 9 [KO:K04358]
101701540  Itgb6; integrin subunit beta 6 [KO:K06589]
101701713  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101701734  Fgf20; fibroblast growth factor 20 [KO:K04358]
101701753  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
101701848  Wasf2; WAS protein family member 2 [KO:K05748]
101701994  Itga10; integrin subunit alpha 10 [KO:K06586]
101702102  Chrm1; cholinergic receptor muscarinic 1 [KO:K04129]
101702445  Itgb5; integrin subunit beta 5 [KO:K06588]
101702483  Actg1; actin gamma 1 [KO:K05692]
101702532  Itga2; integrin subunit alpha 2 [KO:K06481]
101702660  Mos; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
101702687  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101702742  Myh14; myosin heavy chain 14 [KO:K10352]
101702762  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
101702836  Itga7; integrin subunit alpha 7 [KO:K06583]
101702863  Myh9; myosin heavy chain 9 [KO:K10352]
101703242  Itga1; integrin subunit alpha 1 [KO:K06480]
101703244  C8g; complement C8 gamma chain [KO:K03999]
101703316  Itgb8; integrin subunit beta 8 [KO:K06591]
101703623  Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
101703691  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
101703827  Src; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
101703921  Itgb2; integrin subunit beta 2 [KO:K06464]
101704055  Apc; APC, WNT signaling pathway regulator [KO:K02085]
101704236  Mylk; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
101704392  Ssh2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101705091  Pip4k2a; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
101705215  Itga6; integrin subunit alpha 6 [KO:K06485]
101705294  Pikfyve; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
101705408  Ppp1ca; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
101705685  Wasf1; WAS protein family member 1 [KO:K05753]
101705695  Crkl; CRK like proto-oncogene, adaptor protein [KO:K04438]
101706099  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101706200  Pak6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
101706434  Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101706471  Enah; enabled homolog (Drosophila) [KO:K05746]
101706890  Brk1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
101707008  Ssh3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101707562  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101707578  Fgf10; fibroblast growth factor 10 [KO:K04358]
101707706  Fgf17; fibroblast growth factor 17 [KO:K04358]
101707718  Iqgap2; IQ motif containing GTPase activating protein 2 [KO:K05767]
101707893  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
101708079  Gsn; gelsolin [KO:K05768]
101708106  Diaph1; diaphanous related formin 1 [KO:K05740]
101708544  F2r; coagulation factor II thrombin receptor [KO:K03914]
101708581  Cyfip2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
101708848  Pip4k2c; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
101709042  Mras; muscle RAS oncogene homolog [KO:K07831]
101709077  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101709082  Pfn4; profilin family member 4 [KO:K05759]
101709465  Diaph3; diaphanous related formin 3 [KO:K05745]
101709701  Bcar1; BCAR1, Cas family scaffolding protein [KO:K05726]
101709723  Itga4; integrin subunit alpha 4 [KO:K06483]
101710080  [KO:K03994]
101710109  Rhoa; ras homolog family member A [KO:K04513]
101710116  Itga11; integrin subunit alpha 11 [KO:K06587]
101710271  Actn4; actinin alpha 4 [KO:K05699]
101710435  C5; complement C5 [KO:K03994]
101710458  Fgf3; fibroblast growth factor 3 [KO:K04358]
101710589  Rock1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
101710712  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
101710827  Fgf19; fibroblast growth factor 19 [KO:K22603]
101710927  Pdgfc; platelet derived growth factor C [KO:K05450]
101711253  Itgb1; integrin subunit beta 1 [KO:K05719]
101711269  [KO:K04393]
101711414  Actr2; ARP2 actin related protein 2 homolog [KO:K17260]
101711489  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
101711587  Ptk2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
101711651  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101711839  Actn1; actinin alpha 1 [KO:K05699]
101711880  Arpc2; actin related protein 2/3 complex subunit 2 [KO:K05758]
101711919  Fgf4; fibroblast growth factor 4 [KO:K04358]
101711934  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
101711984  Tiam1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
101712444  Mylk2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
101712509  Msn; moesin [KO:K05763]
101712811  Pak3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
101712941  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
101713333  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
101713465  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
101713627  Arhgef4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
101713698  Fgf23; fibroblast growth factor 23 [KO:K22428]
101713815  Diaph2; diaphanous related formin 2 [KO:K05741]
101713836  Cfl1; cofilin 1 [KO:K05765]
101713909  Myl2; myosin light chain 2 [KO:K10351]
101713980  Rdx; radixin [KO:K05762]
101713994  Arhgef7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
101714076  Fgf7; fibroblast growth factor 7 [KO:K04358]
101714286  Chrm2; cholinergic receptor muscarinic 2 [KO:K04130]
101714332  Itga2b; integrin subunit alpha 2b [KO:K06476]
101714346  [KO:K10351]
101714373  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101714468  Ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
101714623  Nckap1; NCK associated protein 1 [KO:K05750]
101714823  Ssh1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101714860  [KO:K05746]
101714885  Itga5; integrin subunit alpha 5 [KO:K06484]
101715249  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
101715533  Arpc5; actin related protein 2/3 complex subunit 5 [KO:K05754]
101715628  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101715697  Cfl2; cofilin 2 [KO:K05765]
101715820  Cyfip1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
101715910  Itgb3; integrin subunit beta 3 [KO:K06493]
101716030  Fgf16; fibroblast growth factor 16 [KO:K04358]
101716052  Iqgap3; IQ motif containing GTPase activating protein 3 [KO:K05767]
101716053  Hras; HRas proto-oncogene, GTPase [KO:K02833]
101716148  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
101716487  Myl9; myosin light chain 9 [KO:K12755]
101716508  Nckap1l; NCK associated protein 1 like [KO:K05750]
101716608  Arpc5l; actin related protein 2/3 complex subunit 5 like [KO:K05754]
101716730  Fam49a; family with sequence similarity 49 member A [KO:K27976]
101716743  Vav3; vav guanine nucleotide exchange factor 3 [KO:K05730]
101717096  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101717104  Itga9; integrin subunit alpha 9 [KO:K06585]
101717255  Actb; actin beta [KO:K05692]
101717585  Crk; CRK proto-oncogene, adaptor protein [KO:K04438]
101717672  Itgav; integrin subunit alpha V [KO:K06487]
101717777  Fgf1; fibroblast growth factor 1 [KO:K18496]
101717974  Fgf21; fibroblast growth factor 21 [KO:K22429]
101718198  Vcl; vinculin [KO:K05700]
101718361  Chrm3; cholinergic receptor muscarinic 3 [KO:K04131]
101718570  Fn1; fibronectin 1 [KO:K05717]
101718612  Dock1; dedicator of cytokinesis 1 [KO:K13708]
101718732  Itgax; integrin alpha-X [KO:K06462]
101718815  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
101718855  Scin; scinderin [KO:K05768]
101718942  Actr3; ARP3 actin related protein 3 homolog [KO:K18584]
101718946  Fgf18; fibroblast growth factor 18 [KO:K04358]
101718997  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
101719164  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101719201  Chrm5; cholinergic receptor muscarinic 5 [KO:K04133]
101719269  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
101719288  Itgam; integrin subunit alpha M [KO:K06461]
101719355  Arhgap35; Rho GTPase activating protein 35 [KO:K05732]
101719378  Gna13; G protein subunit alpha 13 [KO:K04639]
101719424  Myh10; myosin heavy chain 10 [KO:K10352]
101719532  Pfn1; profilin 1 [KO:K05759]
101719620  Itgb7; integrin subunit beta 7 [KO:K06590]
101719792  Pip4k2b; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
101719916  Arpc3; actin related protein 2/3 complex subunit 3 [KO:K05756]
101719948  C6; complement C6 [KO:K03995]
101719971  Ins; insulin [KO:K04526]
101720101  Fgd1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
101720196  Iqgap1; IQ motif containing GTPase activating protein 1 [KO:K16848]
101720492  Pak4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
101720536  Fgf22; fibroblast growth factor 22 [KO:K04358]
101720561  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
101720583  Fgf2; fibroblast growth factor 2 [KO:K18497]
101721023  Kng1; kininogen 1 [KO:K03898]
101721151  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101721307  Myl7; myosin light chain 7 [KO:K12754]
101721526  Myh11; myosin heavy chain 11 [KO:K10352]
101721601  C7; complement C7 [KO:K03996]
101721633  Ezr; ezrin [KO:K08007]
101721643  Mylpf; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
101721831  Vav2; vav guanine nucleotide exchange factor 2 [KO:K05730]
101721841  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101721865  Arhgef1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
101721970  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
101722241  Pfn3; profilin 3 [KO:K05759]
101722671  Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
101722884  Fgf6; fibroblast growth factor 6 [KO:K04358]
101722912  Cxcl12; C-X-C motif chemokine ligand 12 [KO:K10031]
101723157  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
101723449  Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
101723603  Abi2; abl interactor 2 [KO:K05751]
101723643  Itgal; integrin subunit alpha L [KO:K05718]
101723648  Bdkrb2; bradykinin receptor B2 [KO:K03916]
101723771  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101723777  Rac3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
101723821  [KO:K03994]
101724010  Bdkrb1; bradykinin receptor B1 [KO:K03915]
101724195  Rock2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
101724376  Itga8; integrin subunit alpha 8 [KO:K06584]
101724607  Arpc1a; actin related protein 2/3 complex subunit 1A [KO:K05757]
101724784  Slc9a1; solute carrier family 9 member A1 [KO:K05742]
101724927  Spata13; spermatogenesis associated 13 [KO:K05769]
101725000  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
101725049  Insrr; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
101725110  Gng12; G protein subunit gamma 12 [KO:K04347]
101725202  Itgae; integrin subunit alpha E [KO:K06524]
101725609  Arpc1b; actin related protein 2/3 complex subunit 1B [KO:K05757]
101725668  Fgd3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
101725739  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
101725935  Pfn2; profilin 2 [KO:K05759]
101726037  Tmsb4x; thymosin beta 4, X-linked [KO:K05764]
101726083  Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
101726411  Chrm4; cholinergic receptor muscarinic 4 [KO:K04132]
101726632  C9; complement C9 [KO:K04000]
106007518  [KO:K06594]
106007527  Egf; epidermal growth factor [KO:K04357]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hgl04010  MAPK signaling pathway
hgl04510  Focal adhesion
hgl04520  Adherens junction
KO pathway
ko04810   

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