KEGG   PATHWAY: iti04015
Entry
iti04015                    Pathway                                
Name
Rap1 signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
iti04015  Rap1 signaling pathway
iti04015

Other DBs
GO: 0007264
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954382  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
101954421  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101954444  P2ry1; P2Y purinoceptor 1 [KO:K04270]
101954496  [KO:K05692]
101954575  Prkd2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
101954660  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
101954667  Fgf18; fibroblast growth factor 18 [KO:K04358]
101954767  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101954934  Grin2b; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
101954994  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101955058  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
101955098  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101955103  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101955133  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
101955384  Vegfc; vascular endothelial growth factor C [KO:K05449]
101955522  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101955670  Rapgef4; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 4 [KO:K04351]
101955681  Crk; adapter molecule crk isoform X1 [KO:K04438]
101955806  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101955809  [KO:K05096] [EC:2.7.10.1]
101956072  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101956163  Itgal; integrin alpha-L isoform X1 [KO:K05718]
101956879  Lcp2; lymphocyte cytosolic protein 2 [KO:K07361]
101956917  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101957209  Kit; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101957333  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101957420  Prkd1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
101957478  [KO:K17700]
101957564  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
101957631  F2r; proteinase-activated receptor 1 [KO:K03914]
101957687  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101957833  Fgf20; fibroblast growth factor 20 [KO:K04358]
101957854  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
101957872  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101958056  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
101958232  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101958429  Vav2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
101958638  Actb; actin, cytoplasmic 1 [KO:K05692]
101958696  Actg1; actin, cytoplasmic 2 [KO:K05692]
101958796  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
101958798  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
101958853  [KO:K04358]
101959100  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
101959358  [KO:K04513]
101959552  Adora2a; adenosine receptor A2a [KO:K04266]
101959706  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101959870  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
101959882  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101959985  Hras; GTPase HRas isoform X2 [KO:K02833]
101960006  Enah; protein enabled homolog isoform X1 [KO:K05746]
101960162  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X4 [KO:K06277]
101960211  Vegfb; vascular endothelial growth factor B [KO:K16858]
101960404  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101960436  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101960440  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101960493  Rapgef5; rap guanine nucleotide exchange factor 5 [KO:K08019]
101960522  [KO:K06274]
101960649  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101960744  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101960769  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101961077  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101961192  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101961291  Rras; ras-related protein R-Ras [KO:K07829]
101961338  Lat; linker for activation of T-cells family member 1 [KO:K07362]
101961381  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101961479  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101961606  Adora2b; adenosine receptor A2b isoform X1 [KO:K04267]
101961610  Pgf; placenta growth factor isoform X1 [KO:K16859]
101961819  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
101961937  Vegfd; vascular endothelial growth factor D [KO:K05449]
101962014  Src; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101962025  Fgf4; fibroblast growth factor 4 [KO:K04358]
101962028  Evl; ena/VASP-like protein isoform X1 [KO:K23487]
101962074  [KO:K07836]
101962360  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101962660  [KO:K00922] [EC:2.7.1.153]
101962705  [KO:K05631]
101962747  Pfn4; profilin-4 [KO:K05759]
101962866  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
101962974  Vav1; proto-oncogene vav [KO:K05730]
101963400  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
101963438  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101963453  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101963540  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101963744  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101963776  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101963872  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101963929  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101964114  Kras; GTPase KRas isoform X1 [KO:K07827]
101964126  Efna2; ephrin-A2 [KO:K05462]
101964244  Itgb2; integrin beta-2 [KO:K06464]
101964304  Efna4; ephrin-A4 [KO:K05462]
101964440  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
101964484  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
101964547  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101964638  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101964684  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101964713  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101964766  Efna1; ephrin-A1 [KO:K05462]
101964841  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
101964920  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101964927  Ralgds; ral guanine nucleotide dissociation stimulator [KO:K08732]
101964948  Cnr1; cannabinoid receptor 1 [KO:K04277]
101965101  Mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101965394  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101965740  Itgb3; integrin beta-3 [KO:K06493]
101965906  [KO:K00922] [EC:2.7.1.153]
101966082  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101966144  [KO:K04393]
101966207  Ins; insulin precursor [KO:K04526]
101966264  Fgf16; fibroblast growth factor 16 [KO:K04358]
101966346  Rgs14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
101966361  Pfn1; profilin-1 [KO:K05759]
101966404  Skap1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
101966426  Rhoa; transforming protein RhoA [KO:K04513]
101966810  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101966977  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101967074  Calm1; calmodulin-1 [KO:K02183]
101967119  Pfn3; profilin-3 [KO:K05759]
101967121  Sipa1; signal-induced proliferation-associated protein 1 [KO:K08013]
101967251  [KO:K05759]
101967288  [KO:K04632]
101967302  Ctnnd1; catenin delta-1 isoform X5 [KO:K05690]
101967439  Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X2 [KO:K17702]
101967598  Fgf23; fibroblast growth factor 23 [KO:K22428]
101967780  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
101967887  Fgf6; fibroblast growth factor 6 [KO:K04358]
101968091  Cdh1; cadherin-1 [KO:K05689]
101968098  Fgf10; fibroblast growth factor 10 [KO:K04358]
101968510  Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X2 [KO:K17701]
101968846  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101968890  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
101968896  [KO:K00922] [EC:2.7.1.153]
101968931  Pard3; partitioning defective 3 homolog isoform X2 [KO:K04237]
101969226  Fgf3; fibroblast growth factor 3 [KO:K04358]
101969487  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
101969501  Fgf19; fibroblast growth factor 19 [KO:K22603]
101969560  Afdn; afadin isoform X13 [KO:K05702]
101969595  Rap1b; ras-related protein Rap-1b [KO:K07836]
101969684  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
101969789  Fgf22; fibroblast growth factor 22 isoform X3 [KO:K04358]
101969987  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101970466  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101970499  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
101970679  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101970700  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101970750  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101971027  [KO:K04632]
101971159  [KO:K04513]
101971244  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101971364  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101971540  Prkd3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
101971563  Prkcz; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101971818  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101971998  [KO:K04634]
101972098  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101972410  Crkl; crk-like protein isoform X1 [KO:K04438]
101972436  Calml6; calmodulin-like protein 6 [KO:K02183]
101972472  Calm2; calmodulin-2 [KO:K02183]
101972525  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
101972668  Kitlg; kit ligand isoform X1 [KO:K05461]
101972732  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
101972903  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101973163  Egf; pro-epidermal growth factor [KO:K04357]
101973300  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
101973720  [KO:K08014]
101973767  [KO:K06274]
101973797  [KO:K04172]
101973838  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101973902  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101973940  Angpt2; angiopoietin-2 [KO:K05466]
101973998  Fyb1; FYN-binding protein 1 isoform X3 [KO:K17698]
101974200  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101974399  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
101974403  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
101974517  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101974621  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101974670  Itgam; integrin alpha-M [KO:K06461]
101974715  Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X3 [KO:K06082]
101974727  [KO:K17704]
101974776  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101974903  Dock4; dedicator of cytokinesis protein 4 [KO:K17697]
101975217  [KO:K02183]
101975259  Fgf7; fibroblast growth factor 7 [KO:K04358]
101975260  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101975344  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [KO:K05860] [EC:3.1.4.11]
101975438  Fgf21; fibroblast growth factor 21 [KO:K22429]
101975529  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101975833  Rala; ras-related protein Ral-A isoform X1 [KO:K07834]
101975841  Sipa1l3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
101975906  Nras; GTPase NRas [KO:K07828]
101976082  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101976085  [KO:K05759]
101976129  Angpt4; angiopoietin-4 isoform X2 [KO:K05467]
101976168  Itga2b; integrin alpha-IIb isoform X2 [KO:K06476]
101976353  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101976382  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
101976449  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101976513  [KO:K02183]
101976578  Ralb; ras-related protein Ral-B [KO:K07835]
101976716  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101976794  Calml5; calmodulin-like protein 5 [KO:K02183]
101976957  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101977052  Fgf9; fibroblast growth factor 9 [KO:K04358]
101977192  Rassf5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
101977220  Tln2; talin-2 isoform X2 [KO:K06271]
101977233  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101977479  Ngf; beta-nerve growth factor [KO:K02582]
101977507  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101977572  Efna3; ephrin-A3 [KO:K05462]
101977694  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101977788  Adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101977965  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101978014  Tln1; talin-1 [KO:K06271]
101978138  Calm3; calmodulin-3 isoform X2 [KO:K02183]
101978230  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101978392  Efna5; ephrin-A5 [KO:K05462]
101978523  Pard6g; partitioning defective 6 homolog gamma isoform X2 [KO:K06093]
101978560  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101978712  Krit1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
106144716  [KO:K05450]
110598275  [KO:K10785]
120884511  Pfn2; profilin-2 [KO:K05759]
120891809  [KO:K10785]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
iti04010  MAPK signaling pathway
iti04014  Ras signaling pathway
iti04020  Calcium signaling pathway
iti04151  PI3K-Akt signaling pathway
iti04510  Focal adhesion
iti04520  Adherens junction
iti04660  T cell receptor signaling pathway
iti04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

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