KEGG   PATHWAY: iti04014
Entry
iti04014                    Pathway                                
Name
Ras signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
iti04014  Ras signaling pathway
iti04014

Other DBs
GO: 0032318
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954284  Rasgrp1; RAS guanyl-releasing protein 1 isoform X2 [KO:K04350]
101954409  Rgl2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
101954451  Bdnf; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101954566  Exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
101954569  Rab5b; ras-related protein Rab-5B isoform X1 [KO:K07888]
101954667  Fgf18; fibroblast growth factor 18 [KO:K04358]
101954676  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101954707  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101954847  [KO:K04545]
101954920  Gab1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
101954934  Grin2b; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
101954994  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101955098  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101955103  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101955124  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101955131  Pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101955264  Ikbkg; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101955316  Rela; transcription factor p65 [KO:K04735]
101955352  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
101955383  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101955384  Vegfc; vascular endothelial growth factor C [KO:K05449]
101955436  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101955522  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101955561  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101955806  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101955809  [KO:K05096] [EC:2.7.10.1]
101955938  Rasal2; ras GTPase-activating protein nGAP isoform X2 [KO:K17633]
101955964  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101956072  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101956312  Pla2g4d; cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
101956319  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101956398  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101956431  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101956768  Ksr2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
101956917  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101956926  Abl1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
101957209  Kit; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101957333  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101957398  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101957470  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101957564  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
101957687  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101957833  Fgf20; fibroblast growth factor 20 [KO:K04358]
101957872  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101958304  Ralgapb; ral GTPase-activating protein subunit beta isoform X6 [KO:K25769]
101958450  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101958796  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
101958853  [KO:K04358]
101959100  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
101959321  Rasa3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
101959358  [KO:K04513]
101959359  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101959985  Hras; GTPase HRas isoform X2 [KO:K02833]
101960134  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
101960211  Vegfb; vascular endothelial growth factor B [KO:K16858]
101960401  Shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
101960404  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101960429  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101960493  Rapgef5; rap guanine nucleotide exchange factor 5 [KO:K08019]
101960598  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
101960744  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101960769  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101960864  [KO:K01047] [EC:3.1.1.4]
101960867  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101961072  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101961078  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101961192  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101961289  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
101961291  Rras; ras-related protein R-Ras [KO:K07829]
101961338  Lat; linker for activation of T-cells family member 1 [KO:K07362]
101961373  Rasal1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
101961381  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101961479  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101961610  Pgf; placenta growth factor isoform X1 [KO:K16859]
101961905  Elk1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
101961915  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
101961937  Vegfd; vascular endothelial growth factor D [KO:K05449]
101962025  Fgf4; fibroblast growth factor 4 [KO:K04358]
101962074  [KO:K07836]
101962115  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101962162  Foxo4; forkhead box protein O4 isoform X1 [KO:K12358]
101962360  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101962660  [KO:K00922] [EC:2.7.1.153]
101962695  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101962777  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101962937  Ralgapa2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
101963124  Sos2; son of sevenless homolog 2 [KO:K03099]
101963207  Shoc2; leucine-rich repeat protein SHOC-2 [KO:K19613]
101963269  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101963358  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101963371  Mapk8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101963400  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
101963540  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101963674  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101963760  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101963776  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101963872  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101963929  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101964114  Kras; GTPase KRas isoform X1 [KO:K07827]
101964126  Efna2; ephrin-A2 [KO:K05462]
101964304  Efna4; ephrin-A4 [KO:K05462]
101964547  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101964593  Ralbp1; ralA-binding protein 1 [KO:K08773]
101964638  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101964645  [KO:K04545]
101964684  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101964718  Rgl1; ral guanine nucleotide dissociation stimulator-like 1 isoform X2 [KO:K17635]
101964766  Efna1; ephrin-A1 [KO:K05462]
101964841  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
101964861  Rasa4b; LOW QUALITY PROTEIN: ras GTPase-activating protein 4B [KO:K17630]
101964927  Ralgds; ral guanine nucleotide dissociation stimulator [KO:K08732]
101965040  Pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101965108  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101965324  Rab5c; ras-related protein Rab-5C [KO:K07889]
101965569  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101965843  Ets1; protein C-ets-1 isoform X4 [KO:K02678]
101965906  [KO:K00922] [EC:2.7.1.153]
101966065  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101966092  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101966144  [KO:K04393]
101966207  Ins; insulin precursor [KO:K04526]
101966264  Fgf16; fibroblast growth factor 16 [KO:K04358]
101966388  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
101966426  Rhoa; transforming protein RhoA [KO:K04513]
101966501  Igf2; insulin-like growth factor II isoform X2 [KO:K13769]
101966977  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101967074  Calm1; calmodulin-1 [KO:K02183]
101967295  [KO:K10632] [EC:2.3.2.27]
101967335  Ntf3; neurotrophin-3 [KO:K04356]
101967372  Ralgapa1; ral GTPase-activating protein subunit alpha-1 isoform X4 [KO:K25768]
101967598  Fgf23; fibroblast growth factor 23 [KO:K22428]
101967689  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101967809  [KO:K04410] [EC:2.7.11.1]
101967887  Fgf6; fibroblast growth factor 6 [KO:K04358]
101968098  Fgf10; fibroblast growth factor 10 [KO:K04358]
101968308  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
101968522  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101968814  Gab2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
101968854  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101968856  Ntrk2; BDNF/NT-3 growth factors receptor isoform X4 [KO:K04360] [EC:2.7.10.1]
101968890  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
101968896  [KO:K00922] [EC:2.7.1.153]
101968941  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
101969226  Fgf3; fibroblast growth factor 3 [KO:K04358]
101969278  Tgfa; protransforming growth factor alpha isoform X2 [KO:K08774]
101969446  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101969447  Rel; proto-oncogene c-Rel isoform X1 [KO:K09254]
101969501  Fgf19; fibroblast growth factor 19 [KO:K22603]
101969560  Afdn; afadin isoform X13 [KO:K05702]
101969595  Rap1b; ras-related protein Rap-1b [KO:K07836]
101969627  Rab5a; ras-related protein Rab-5A [KO:K07887]
101969684  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
101969789  Fgf22; fibroblast growth factor 22 isoform X3 [KO:K04358]
101969987  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101970466  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101970499  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
101970651  Nf1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
101970679  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101970700  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101970750  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101970798  [KO:K04570]
101970818  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101970905  [KO:K12457]
101970930  Ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
101971159  [KO:K04513]
101971169  [KO:K19613]
101971364  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101971458  [KO:K07360] [EC:2.7.10.2]
101971818  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101972098  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101972153  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101972224  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
101972308  Pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101972421  Pla2g4f; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
101972436  Calml6; calmodulin-like protein 6 [KO:K02183]
101972472  Calm2; calmodulin-2 [KO:K02183]
101972573  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101972668  Kitlg; kit ligand isoform X1 [KO:K05461]
101972729  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101972732  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
101972903  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101972956  Rras2; ras-related protein R-Ras2 [KO:K07830]
101973095  Shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101973111  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101973163  Egf; pro-epidermal growth factor [KO:K04357]
101973527  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101973693  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101973838  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101973859  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
101973874  [KO:K04570]
101973902  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101973924  Tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101973940  Angpt2; angiopoietin-2 [KO:K05466]
101974157  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101974399  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
101974572  Arf6; ADP-ribosylation factor 6 [KO:K07941]
101974621  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101974776  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101975134  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101975154  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101975209  Ets2; protein C-ets-2 [KO:K21932]
101975217  [KO:K02183]
101975230  Pla1a; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
101975241  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101975259  Fgf7; fibroblast growth factor 7 [KO:K04358]
101975260  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101975344  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [KO:K05860] [EC:3.1.4.11]
101975438  Fgf21; fibroblast growth factor 21 [KO:K22429]
101975529  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101975825  [KO:K01047] [EC:3.1.1.4]
101975833  Rala; ras-related protein Ral-A isoform X1 [KO:K07834]
101975906  Nras; GTPase NRas [KO:K07828]
101976082  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101976106  [KO:K01047] [EC:3.1.1.4]
101976129  Angpt4; angiopoietin-4 isoform X2 [KO:K05467]
101976353  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101976382  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
101976449  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101976471  Rasal3; RAS protein activator like-3 [KO:K17634]
101976513  [KO:K02183]
101976523  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101976578  Ralb; ras-related protein Ral-B [KO:K07835]
101976595  Syngap1; ras/Rap GTPase-activating protein SynGAP isoform X7 [KO:K17631]
101976632  Rassf1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
101976716  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101976794  Calml5; calmodulin-like protein 5 [KO:K02183]
101976957  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101977048  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101977052  Fgf9; fibroblast growth factor 9 [KO:K04358]
101977192  Rassf5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
101977233  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101977331  Pla2g5; phospholipase A2 group V isoform X3 [KO:K01047] [EC:3.1.1.4]
101977476  Rin1; ras and Rab interactor 1 [KO:K17638]
101977479  Ngf; beta-nerve growth factor [KO:K02582]
101977507  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101977572  Efna3; ephrin-A3 [KO:K05462]
101977604  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101977965  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101978138  Calm3; calmodulin-3 isoform X2 [KO:K02183]
101978230  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101978265  Pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
101978298  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101978392  Efna5; ephrin-A5 [KO:K05462]
101978429  Ntf4; neurotrophin-4 [KO:K12457]
101978453  Abl2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
101978549  Mapk9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
106144716  [KO:K05450]
106145241  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
110598275  [KO:K10785]
120891809  [KO:K10785]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
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Nat Rev Mol Cell Biol 9:517-31 (2008)
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Oncogene 22:8999-9006 (2003)
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Mol Immunol 38:1181-6 (2002)
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Nat Rev Mol Cell Biol 13:39-51 (2012)
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A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
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Oncogene 20:188-97 (2001)
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RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
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J Cell Biol 174:877-88 (2006)
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Trends Immunol 34:259-68 (2013)
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A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
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Mol Cell Biol 24:10515-28 (2004)
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Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
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Biochim Biophys Acta 1815:170-88 (2011)
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  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
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Mol Biosyst 4:213-22 (2008)
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Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
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Curr Biol 14:R277-8 (2004)
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Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
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J Biol Chem 284:11007-11 (2009)
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Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:34074494
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Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
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Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
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KO pathway
ko04014   

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