KEGG   PATHWAY: ko05022
Entry
ko05022                     Pathway                                
Name
Pathways of neurodegeneration - multiple diseases
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ko05022  Pathways of neurodegeneration - multiple diseases
ko05022

Orthology
K00182  WNT2; wingless-type MMTV integration site family, member 2
K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00312  WNT3; wingless-type MMTV integration site family, member 3
K00408  WNT4; wingless-type MMTV integration site family, member 4
K00411  UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414  QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1
K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
K00416  QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6
K00417  QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7
K00418  QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8
K00419  QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9
K00420  QCR10, UQCR; ubiquinol-cytochrome c reductase subunit 10
K00432  gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]
K00444  WNT5; wingless-type MMTV integration site family, member 5
K00445  WNT6; wingless-type MMTV integration site family, member 6
K00572  WNT7; wingless-type MMTV integration site family, member 7
K00714  WNT8; wingless-type MMTV integration site family, member 8
K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K01064  WNT9; wingless-type MMTV integration site family, member 9
K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K01357  WNT10; wingless-type MMTV integration site family, member 10
K01367  CAPN1; calpain-1 [EC:3.4.22.52]
K01384  WNT11; wingless-type MMTV integration site family, member 11
K01558  WNT16; wingless-type MMTV integration site family, member 16
K02084  APAF1; apoptotic protease-activating factor
K02085  APC; adenomatosis polyposis coli protein
K02090  CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]
K02105  CTNNB1; catenin beta 1
K02125  ATPeF08, MTATP8, ATP8; F-type H+-transporting ATPase subunit 8
K02126  ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a
K02127  ATPeF0B, ATP5F1, ATP4; F-type H+-transporting ATPase subunit b
K02128  ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c
K02131  ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6
K02132  ATPeF1A, ATP5A1, ATP1; F-type H+-transporting ATPase subunit alpha
K02133  ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02134  ATPeF1D, ATP5D, ATP16; F-type H+-transporting ATPase subunit delta
K02135  ATPeF1E, ATP5E, ATP15; F-type H+-transporting ATPase subunit epsilon
K02136  ATPeF1G, ATP5C1, ATP3; F-type H+-transporting ATPase subunit gamma
K02137  ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O
K02138  ATPeF0D, ATP5H, ATP7; F-type H+-transporting ATPase subunit d
K02157  AXIN1; axin 1
K02158  BAD; Bcl-2-antagonist of cell death
K02159  BAX; apoptosis regulator BAX
K02161  BCL2; apoptosis regulator Bcl-2
K02165  DKK1_2_4; dickkopf 1/2/4
K02183  CALM; calmodulin
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K02235  FZD2; frizzled 2
K02256  COX1; cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261  COX2; cytochrome c oxidase subunit 2
K02262  COX3; cytochrome c oxidase subunit 3
K02263  COX4; cytochrome c oxidase subunit 4
K02264  COX5A; cytochrome c oxidase subunit 5a
K02265  COX5B; cytochrome c oxidase subunit 5b
K02266  COX6A; cytochrome c oxidase subunit 6a
K02267  COX6B; cytochrome c oxidase subunit 6b
K02268  COX6C; cytochrome c oxidase subunit 6c
K02270  COX7A; cytochrome c oxidase subunit 7a
K02271  COX7B; cytochrome c oxidase subunit 7b
K02272  COX7C; cytochrome c oxidase subunit 7c
K02273  COX8; cytochrome c oxidase subunit 8
K02308  DAXX; death-associated protein 6
K02329  FZD3; frizzled 3
K02353  DVL; segment polarity protein dishevelled
K02354  FZD4, fz4, CD344; frizzled 4
K02373  FADD; FAS-associated death domain protein
K02375  FZD5_8, fz2; frizzled 5/8
K02376  FZD6; frizzled 6
K02432  FZD1_7, fz; frizzled 1/7
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K02725  PSMA1; 20S proteasome subunit alpha 6 [EC:3.4.25.1]
K02726  PSMA2; 20S proteasome subunit alpha 2 [EC:3.4.25.1]
K02727  PSMA3; 20S proteasome subunit alpha 7 [EC:3.4.25.1]
K02728  PSMA4; 20S proteasome subunit alpha 3 [EC:3.4.25.1]
K02729  PSMA5; 20S proteasome subunit alpha 5 [EC:3.4.25.1]
K02730  PSMA6; 20S proteasome subunit alpha 1 [EC:3.4.25.1]
K02731  PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
K02732  PSMB1; 20S proteasome subunit beta 6 [EC:3.4.25.1]
K02734  PSMB2; 20S proteasome subunit beta 4 [EC:3.4.25.1]
K02735  PSMB3; 20S proteasome subunit beta 3 [EC:3.4.25.1]
K02736  PSMB4; 20S proteasome subunit beta 7 [EC:3.4.25.1]
K02737  PSMB5; 20S proteasome subunit beta 5 [EC:3.4.25.1]
K02738  PSMB6; 20S proteasome subunit beta 1 [EC:3.4.25.1]
K02739  PSMB7; 20S proteasome subunit beta 2 [EC:3.4.25.1]
K02833  HRAS; GTPase HRas
K02842  FZD9_10, CD349_50; frizzled 9/10
K02927  RP-L40e, RPL40, UBA52; ubiquitin-large subunit ribosomal protein L40e
K02977  RP-S27Ae, RPS27A, UBA80; ubiquitin-small subunit ribosomal protein S27Ae
K03028  PSMD2, RPN1; 26S proteasome regulatory subunit N1
K03029  PSMD4, RPN10; 26S proteasome regulatory subunit N10
K03030  PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11
K03031  PSMD8, RPN12; 26S proteasome regulatory subunit N12
K03032  PSMD1, RPN2; 26S proteasome regulatory subunit N2
K03033  PSMD3, RPN3; 26S proteasome regulatory subunit N3
K03035  PSMD12, RPN5; 26S proteasome regulatory subunit N5
K03036  PSMD11, RPN6; 26S proteasome regulatory subunit N6
K03037  PSMD6, RPN7; 26S proteasome regulatory subunit N7
K03038  PSMD7, RPN8; 26S proteasome regulatory subunit N8
K03039  PSMD13, RPN9; 26S proteasome regulatory subunit N9
K03061  PSMC2, RPT1; 26S proteasome regulatory subunit T1
K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03063  PSMC4, RPT3; 26S proteasome regulatory subunit T3
K03064  PSMC6, RPT4; 26S proteasome regulatory subunit T4
K03065  PSMC3, RPT5; 26S proteasome regulatory subunit T5
K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
K03068  LRP5_6; low density lipoprotein receptor-related protein 5/6
K03069  FRAT1; frequently rearranged in advanced T-cell lymphomas 1
K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03096  FRAT2; frequently rearranged in advanced T-cell lymphomas 2
K03097  CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115  CSNK2B; casein kinase II subunit beta
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03178  UBE1, UBA1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
K03209  WNT1; wingless-type MMTV integration site family, member 1
K03237  EIF2S1; translation initiation factor 2 subunit 1
K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
K03853  CAPN2; calpain-2 [EC:3.4.22.53]
K03878  ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03934  NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03942  NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K03957  NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K03967  NDUFC1; NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
K04129  CHRM1; muscarinic acetylcholine receptor M1
K04131  CHRM3; muscarinic acetylcholine receptor M3
K04133  CHRM5; muscarinic acetylcholine receptor M5
K04243  GPR37; prosaposin receptor
K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K04355  BDNF; brain-derived neurotrophic factor
K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04380  MAPT, TAU; microtubule-associated protein tau
K04383  IL1A; interleukin 1 alpha
K04385  AXIN2; axin 2
K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04397  CASP7; caspase 7 [EC:3.4.22.60]
K04398  CASP8; caspase 8 [EC:3.4.22.61]
K04399  CASP9; caspase 9 [EC:3.4.22.62]
K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]
K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
K04505  PSEN1, PS1; presenilin 1 [EC:3.4.23.-]
K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04519  IL1B; interleukin 1 beta
K04520  APP; amyloid beta A4 protein
K04522  PSEN2, PS2; presenilin 2 [EC:3.4.23.-]
K04528  SNCA; alpha-synuclein
K04533  HD; huntingtin
K04551  UBB; ubiquitin B
K04552  UBE2L3, UBCH7; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
K04553  UBE2L6, UBCH8; ubiquitin/ISG15-conjugating enzyme E2 L6 [EC:2.3.2.23]
K04554  UBE2J2, NCUBE2, UBC6; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
K04555  UBE2G2, UBC7; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
K04556  PARK2; parkin [EC:2.3.2.31]
K04557  SEPT5, PNUTL1, CDCREL1; septin 5
K04558  SNCAIP; synphilin-1
K04559  HIP1; huntingtin interacting protein 1
K04560  STX1A; syntaxin 1A
K04565  SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
K04569  CCS; copper chaperone for superoxide dismutase
K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04572  NEFL, NF-L; neurofilament light polypeptide
K04573  NEF3, NF-M; neurofilament medium polypeptide (neurofilament 3)
K04574  NEFH, NF-H; neurofilament heavy polypeptide
K04575  ALS2; amyotrophic lateral sclerosis 2 protein
K04603  GRM1; metabotropic glutamate receptor 1
K04604  GRM5; metabotropic glutamate receptor 5
K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04638  IFT57, HIPPI, ESRRBL1; intraflagellar transport protein 57
K04647  HAP1; huntingtin-associated protein 1
K04648  DCTN1; dynactin 1
K04690  FZDN, fz3; frizzled
K04726  BID; BH3 interacting domain death agonist
K04735  RELA; transcription factor p65
K04741  CASP12; caspase 12 [EC:3.4.22.-]
K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
K04961  RYR1; ryanodine receptor 1
K04962  RYR2; ryanodine receptor 2
K04963  RYR3; ryanodine receptor 3
K04966  TRPC3; transient receptor potential cation channel subfamily C member 3
K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
K05141  TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B
K05197  GRIA1; glutamate receptor 1
K05198  GRIA2; glutamate receptor 2
K05199  GRIA3; glutamate receptor 3
K05200  GRIA4; glutamate receptor 4
K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
K05405  IL6; interleukin 6
K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]
K05634  PRNP, PrP, CD230; prion protein
K05687  PARK7; protein DJ-1 [EC:3.5.1.124]
K05688  PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]
K05853  ATP2A; P-type Ca2+ transporter type 2A [EC:7.2.2.10]
K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05862  VDAC1; voltage-dependent anion channel protein 1
K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K05864  PPID, CYPD; peptidyl-prolyl isomerase D [EC:5.2.1.8]
K06030  MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
K06691  RPN13; 26S proteasome regulatory subunit N13
K06693  PSMD9, RPN4; 26S proteasome regulatory subunit N4
K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07374  TUBA; tubulin alpha
K07375  TUBB; tubulin beta
K07607  PRPH; peripherin
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K07874  RAB1A; Ras-related protein Rab-1A
K07887  RAB5A; Ras-related protein Rab-5A
K07901  RAB8A, MEL; Ras-related protein Rab-8A
K07925  RAB39B; Ras-related protein Rab-39B
K08008  NOX1, MOX1; NADPH oxidase 1
K08269  ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K08331  ATG13; autophagy-related protein 13
K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
K08334  BECN, VPS30, ATG6; beclin
K08669  HTRA2, PRSS25; HtrA serine peptidase 2 [EC:3.4.21.108]
K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
K08738  CYC; cytochrome c
K08770  UBC; ubiquitin C
K08844  LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]
K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K08957  CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]
K08960  CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K09027  XBP1; X box-binding protein 1
K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
K09488  TRAP1, HSP75; TNF receptor-associated protein 1
K09490  HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
K09565  PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
K10396  KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
K10407  KLC; kinesin light chain
K10408  DNAH; dynein axonemal heavy chain
K10409  DNAI1; dynein axonemal intermediate chain 1
K10410  DNALI; dynein axonemal light intermediate chain 1
K10411  DNAL1; dynein axonemal light chain 1
K10412  DNAL4; dynein axonemal light chain 4
K10424  DCTN2; dynactin 2
K10425  DCTN3; dynactin 3
K10426  DCTN4; dynactin 4
K10427  DCTN5; dynactin 5
K10428  DCTN6; dynactin 6
K10435  MAP1LC; microtubule-associated protein 1 light chain
K10575  UBE2G1, UBC7; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
K10578  UBE2J1, NCUBE1, UBC6; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
K10698  UBE1L, UBA7; ubiquitin-activating enzyme E1-like [EC:6.2.1.45]
K10707  VAPB, ALS8; vesicle-associated membrane protein-associated protein B
K10881  SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
K11143  DNAI2; dynein axonemal intermediate chain 2
K11351  NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K11352  NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K11518  TOM40; mitochondrial import receptor subunit TOM40
K11519  DERL1; Derlin-1
K11716  CDK5R1; cyclin-dependent kinase 5 activator 1
K11828  DLG4, PSD95; discs large protein 4
K11863  ATXN3, MJD; Ataxin-3 [EC:3.4.22.-]
K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K12192  CHMP2B; charged multivesicular body protein 2B
K12650  TANK; TRAF family member-associated NF-kappa-B activator
K13098  TLS, FUS; RNA-binding protein FUS
K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K13525  VCP, CDC48; transitional endoplasmic reticulum ATPase
K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
K14381  SQSTM1; sequestosome 1
K15040  VDAC2; voltage-dependent anion channel protein 2
K15041  VDAC3; voltage-dependent anion channel protein 3
K15840  PDYN, PENKB; proenkephalin B (prodynorphin)
K16575  ACTR1, ARP1; centractin
K16576  ACTR10, ARP11; actin-related protein 10
K17589  RB1CC1; RB1-inducible coiled-coil protein 1
K17603  ZFYVE1; zinc finger FYVE domain-containing protein 1
K17889  ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
K17906  ATG2; autophagy-related protein 2
K17908  WIPI1_2, ATG18; autophagy-related protein 18
K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
K19026  SPG11; spatacsin
K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K19722  AGER, RAGE; receptor for advanced glycosylation end products
K19730  ATG101; autophagy-related protein 101
K19946  OPTN, FIP2; optineurin
K20719  SIGMAR1; sigma non-opioid intracellular receptor
K20858  MCU; calcium uniporter protein, mitochondrial
K21246  NRBF2; nuclear receptor-binding factor 2
K21356  MFN1; mitofusin 1 [EC:3.6.5.-]
K21357  ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K21421  NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
K21423  NOX4, RENOX; NADPH oxidase 4 [EC:1.6.3.-]
K22913  FIG4; phosphatidylinositol 3,5-bisphosphate 5-phosphatase [EC:3.1.3.-]
K23600  TARDBP, TDP43; TAR DNA-binding protein 43
K23609  C9ORF72; guanine nucleotide exchange protein C9orf72
K23610  WDR41; WD repeat-containing protein 41
K23611  SMCR8; guanine nucleotide exchange protein SMCR8
K23616  ATXN1_1L; ataxin 1/1L
K23625  ATXN2_2L; ataxin 2/2L
K23932  SPTBN2; spectrin beta, non-erythrocytic 2
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Cold Spring Harb Perspect Biol 9:a028035 (2017)
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Front Mol Neurosci 7:70 (2014)
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Reference
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Reference
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Reference
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Related
pathway
ko00190  Oxidative phosphorylation
ko03050  Proteasome
ko04020  Calcium signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04142  Lysosome
ko04210  Apoptosis
ko04310  Wnt signaling pathway
ko04724  Glutamatergic synapse
ko04933  AGE-RAGE signaling pathway in diabetic complications

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