Entry
Name
Salmonella infection - Lemur catta (Ring-tailed lemur)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Disease
Organism
Lemur catta (Ring-tailed lemur) [GN:
lcat ]
Gene
123620563 ARL17A; LOW QUALITY PROTEIN: ADP-ribosylation factor-like 17-like [KO:K07937 ]
123621035 PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
123622527 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
123622664 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
123623040 TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374 ]
123623074 ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755 ]
123623094 FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
123623565 ARL8B; LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B [KO:K07955 ]
123624856 DYNLT3; LOW QUALITY PROTEIN: dynein light chain Tctex-type 3 [KO:K10420 ]
123625188 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
123625194 FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
123625464 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
123625652 RAB7A; LOW QUALITY PROTEIN: ras-related protein Rab-7a [KO:K07897 ]
123626055 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
123626077 VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182 ]
123626753 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
123626809 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
123627174 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
123627206 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
123627840 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
123629856 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
123630266 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
123630278 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
123632689 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
123632745 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
123633357 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
123634506 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
123635952 PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
123636859 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
123637295 GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
123639954 PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
123640135 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
123640344 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
123641274 AHNAK; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934 ]
123641494 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
123642485 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
123643741 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
123644820 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749 ]
123646053 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754 ]
123647039 NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
123647604 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
123647683 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
123647726 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
123647774 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
123648988 WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
123649353 NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
lcat04621 NOD-like receptor signaling pathway
KO pathway