KEGG   PATHWAY: mlk04062
Entry
mlk04062                    Pathway                                
Name
Chemokine signaling pathway - Mustela lutreola (European mink)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
mlk04062  Chemokine signaling pathway
mlk04062

Other DBs
GO: 0070098
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131807291  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131807367  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
131807497  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
131807620  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
131807708  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131807874  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
131808069  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
131808080  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
131808844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
131808851  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
131808860  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
131808912  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131809015  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131809392  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
131810028  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
131810066  [KO:K04393]
131810068  RAP1A; ras-related protein Rap-1A [KO:K04353]
131810079  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
131810162  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
131810292  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
131810307  NRAS; GTPase NRas isoform X1 [KO:K07828]
131810524  [KO:K07828]
131810869  PXN; paxillin isoform X1 [KO:K05760]
131811098  CRKL; crk-like protein [KO:K04438]
131811594  [KO:K04393]
131811641  [KO:K04513]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131811851  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
131811921  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
131812092  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
131812356  CCL27; C-C motif chemokine 27 [KO:K16598]
131812357  [KO:K16598]
131812386  CCL19; C-C motif chemokine 19 isoform X1 [KO:K05512]
131812467  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
131812476  SHC3; SHC-transforming protein 3 [KO:K17448]
131812504  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
131812794  CCL21; C-C motif chemokine 21 [KO:K16062]
131813137  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
131813927  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
131814104  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
131814353  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
131814631  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
131814653  BAD; bcl2-associated agonist of cell death [KO:K02158]
131814933  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131815104  XCL1; lymphotactin [KO:K05507]
131815555  [KO:K21092]
131815556  [KO:K05511]
131815557  CCL16; C-C motif chemokine 16 [KO:K21093]
131815558  [KO:K05408]
131815559  CCL5; C-C motif chemokine 5 [KO:K12499]
131815578  RELA; transcription factor p65 [KO:K04735]
131815763  ARRB2; beta-arrestin-2 [KO:K04439]
131815764  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
131815766  [KO:K11224]
131815847  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
131815902  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
131815965  [KO:K16596]
131815980  [KO:K16595]
131816057  CRK; adapter molecule crk isoform X1 [KO:K04438]
131816137  [KO:K05408]
131816155  [KO:K14624]
131816156  [KO:K05509]
131816253  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
131816262  CCR7; C-C chemokine receptor type 7 [KO:K04182]
131816268  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
131816590  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
131816630  CCR10; C-C chemokine receptor type 10 isoform X1 [KO:K04185]
131816711  [KO:K05408]
131816743  CCL4; C-C motif chemokine 4 [KO:K12964]
131816784  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
131816825  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
131816868  CCL1; C-C motif chemokine 1 [KO:K05514]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817521  GSK3A; glycogen synthase kinase-3 alpha isoform X1 [KO:K08822] [EC:2.7.11.26]
131817751  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
131817944  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
131818029  CCL17; C-C motif chemokine 17 [KO:K21083]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131818341  CX3CL1; fractalkine [KO:K05508]
131818548  CCL22; C-C motif chemokine 22 [KO:K21095]
131818734  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
131818745  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
131818792  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
131818968  [KO:K05407]
131819170  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
131819498  CCL24; C-C motif chemokine 24 [KO:K21097]
131819499  CCL26; C-C motif chemokine 26 [KO:K21096]
131819600  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131819646  NCF1; neutrophil cytosol factor 1 [KO:K08011]
131819826  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131819927  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
131820002  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131820342  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
131821625  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
131821720  WAS; actin nucleation-promoting factor WAS isoform X1 [KO:K05747]
131821819  CXCR3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
131822182  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
131822783  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
131822799  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
131822815  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
131823143  SHC2; SHC-transforming protein 2 [KO:K17447]
131823163  [KO:K05505]
131823170  [KO:K05505]
131823183  [KO:K05505]
131823197  [KO:K10029]
131823204  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
131823207  CXCL8; interleukin-8 [KO:K10030]
131823267  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
131823393  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
131823580  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
131823635  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
131823743  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
131823754  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131823842  CCR9; C-C chemokine receptor type 9 [KO:K04184]
131823845  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
131823846  XCR1; chemokine XC receptor 1 [KO:K04193]
131823847  [KO:K04176]
131823848  [KO:K04178]
131823850  CCR2; C-C chemokine receptor type 2 [KO:K04177]
131823851  [KO:K04180]
131823928  RHOA; transforming protein RhoA [KO:K04513]
131823969  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
131824034  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131824348  CCR8; C-C chemokine receptor type 8 [KO:K04183]
131824350  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
131824399  CCR4; C-C chemokine receptor type 4 [KO:K04179]
131824589  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131824632  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
131824844  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
131824847  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131825059  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
131825080  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
131825301  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
131825716  CCL25; C-C motif chemokine 25 [KO:K13072]
131826363  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
131826395  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
131826820  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
131826899  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
131826966  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
131827466  [KO:K04175]
131827467  [KO:K05050]
131827656  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
131828138  [KO:K04542]
131828172  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
131828549  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
131828696  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
131829051  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
131829179  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
131829247  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
131829305  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
131829387  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
131829388  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
131829620  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
131829849  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
131829855  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
131830625  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
131831568  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
131831717  CCL28; C-C motif chemokine 28 [KO:K05513]
131831830  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
131831893  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
131831978  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
131832068  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
131832309  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131833155  [KO:K04393]
131833269  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
131833362  CCR6; C-C chemokine receptor type 6 [KO:K04181]
131833536  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
131835957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
131836105  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
131836254  SHC4; SHC-transforming protein 4 [KO:K17449]
131836300  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
131836404  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
131836470  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
131836536  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
131836560  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
131836834  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131838003  [KO:K04347]
131838311  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
131838470  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
131838598  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
131838820  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
131838926  KRAS; GTPase KRas isoform X1 [KO:K07827]
131839131  RAP1B; ras-related protein Rap-1b [KO:K07836]
131839444  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
131840354  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
131840500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131840630  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
mlk04010  MAPK signaling pathway
mlk04060  Cytokine-cytokine receptor interaction
mlk04120  Ubiquitin mediated proteolysis
mlk04630  JAK-STAT signaling pathway
mlk04670  Leukocyte transendothelial migration
mlk04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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