KEGG   PATHWAY: aamp05010
Entry
aamp05010                   Pathway                                
Name
Alzheimer disease - Arvicola amphibius (Eurasian water vole)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
aamp05010  Alzheimer disease
aamp05010

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119809064  Adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
119807826  Adam17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
119825083  amyloid-beta precursor protein isoform X1 [KO:K04520]
119802089  Nae1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
119815122  Apbb1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
119814898  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119815417  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119807305  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase, testis-specific-like [KO:K00134] [EC:1.2.1.12]
119809429  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119809155  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119815493  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119809687  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119816981  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119823438  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
119823565  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
119804638  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119804679  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119805300  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119805853  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119812736  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119826241  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119826248  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119826257  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119806583  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
119800152  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119807293  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119809046  Bace1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
119825049  Bace2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
119812120  Rtn3; reticulon-3 [KO:K20723]
119802559  Rtn4; reticulon-4 isoform X1 [KO:K20720]
119821170  Psenen; gamma-secretase subunit PEN-2 isoform X1 [KO:K06170]
119821506  gamma-secretase subunit PEN-2-like [KO:K06170]
119818546  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
119827510  Psen2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
119827899  Ncstn; nicastrin [KO:K06171]
119800918  Aph1a; LOW QUALITY PROTEIN: gamma-secretase subunit APH-1A [KO:K06172]
119810336  Aph1b; gamma-secretase subunit APH-1B [KO:K06172]
119802916  LOW QUALITY PROTEIN: insulin-degrading enzyme-like [KO:K01408] [EC:3.4.24.56]
119809108  Ide; insulin-degrading enzyme [KO:K01408] [EC:3.4.24.56]
119826806  Mme; neprilysin [KO:K01389] [EC:3.4.24.11]
119812136  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
119815378  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119821089  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
119823492  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
119804764  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
119814379  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
119808469  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
119821547  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
119822367  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119816292  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119817139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119800371  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119808111  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
119803343  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
119813558  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119807886  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
119810302  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
119822816  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
119815606  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
119825491  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
119819937  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
119807526  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
119821505  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
119810151  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
119827973  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
119808788  acyl carrier protein, mitochondrial-like [KO:K03955]
119812443  acyl carrier protein, mitochondrial-like [KO:K03955]
119807454  acyl carrier protein, mitochondrial [KO:K03955]
119810775  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
119811058  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
119803407  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
119813692  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
119818574  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
119800598  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
119806913  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
119804078  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
119825606  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
119825940  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
119825963  Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
119801780  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
119811753  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
119823332  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
119812927  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
119804641  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
119804932  LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934] [EC:7.1.1.2]
119820696  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
119827486  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
119814166  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
119810090  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
119809107  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119803219  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810541  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119816982  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
119818379  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119825922  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810417  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
119821308  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
119814511  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
119826441  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
119802653  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
119809157  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
119816786  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
119827624  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
119809004  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
119816634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
119822897  cytochrome c1, heme protein, mitochondrial [KO:K00413]
119810716  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
119818376  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
119817782  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
119823100  cytochrome b-c1 complex subunit 7 [KO:K00417]
119826150  cytochrome b-c1 complex subunit 7 [KO:K00417]
119812643  cytochrome b-c1 complex subunit 8 [KO:K00418]
119822943  cytochrome b-c1 complex subunit 10 [KO:K00420]
119824516  cytochrome b-c1 complex subunit 10-like [KO:K00420]
119801810  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
119815669  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
119808969  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
119820956  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119800700  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119823348  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
119824540  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119813186  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119826874  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
119821317  cytochrome c oxidase subunit 6B2 [KO:K02267]
119803616  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119812348  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119820632  cytochrome c oxidase subunit 6B1 [KO:K02267]
119823502  cytochrome c oxidase subunit 6C-2 [KO:K02268]
119804134  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
119808129  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
119821387  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
119810497  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
119820589  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
119821824  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
119824561  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
119804752  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
119807117  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
119818750  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119809813  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
119824069  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119822805  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
119818361  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
119806473  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
119814908  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
119803617  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119801085  ATP synthase subunit gamma, mitochondrial [KO:K02136]
119816174  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
119821561  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
119814896  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
119800757  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
119807929  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119827952  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119822775  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119818833  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
119812397  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
119826216  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
119807061  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119817869  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
119812417  Atp5pd; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
119824792  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
119825399  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119813406  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119824693  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
119804867  Hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
119819446  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
119826784  Ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119800149  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119812859  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119827941  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119812456  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
119821491  Apoe; apolipoprotein E [KO:K04524]
119803370  Lrp1; LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119806482  Bid; BH3-interacting domain death agonist [KO:K04726]
119821021  Calm3; calmodulin-3 [KO:K02183]
119808332  Calm2; calmodulin-2 [KO:K02183]
119808754  Calml4; calmodulin-like protein 4 [KO:K02183]
119809106  calmodulin-1 [KO:K02183]
119815477  calmodulin-1 [KO:K02183]
119817551  Calml3; calmodulin-like protein 3 [KO:K02183]
119817552  calmodulin-4-like [KO:K02183]
119818370  Calm1; calmodulin-1 [KO:K02183]
119800939  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
119800012  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119800123  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119823004  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
119826596  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119807948  cytochrome c, somatic-like [KO:K08738]
119827640  cytochrome c, somatic-like [KO:K08738]
119812378  cytochrome c, somatic [KO:K08738]
119812503  cytochrome c, somatic-like [KO:K08738]
119819008  cytochrome c, testis-specific [KO:K08738]
119807481  cytochrome c, somatic [KO:K08738]
119803346  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119799823  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
119816034  Chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
119815576  Chrm5; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5 [KO:K04133]
119802846  Grm5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
119812597  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119814344  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814366  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814933  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
119824882  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119818834  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
119812911  Grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
119806515  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
119812477  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
119802465  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
119806908  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119828004  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119804579  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119827234  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
119802858  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
119823855  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119815223  Ryr3; ryanodine receptor 3 [KO:K04963]
119806390  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119806213  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119823109  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119824551  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119826284  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119813074  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
119827727  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
119811524  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
119803285  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
119812025  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
119808167  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119818726  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119820587  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119824883  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119818610  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119822546  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119819422  Psma6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
119806930  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
119816961  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
119810264  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
119826499  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
119814848  Psma8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
119814251  Psma7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
119800933  Psma5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
119826314  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
119807368  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
119818710  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
119811925  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
119818701  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
119808982  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
119804953  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
119805275  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
119812338  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
119799913  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
119817964  Psmb2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
119800066  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
119821027  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
119801014  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
119826096  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 7-like [KO:K03061]
119803931  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
119819347  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
119821340  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
119800168  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
119814467  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
119817394  26S proteasome regulatory subunit 8-like [KO:K03066]
119811765  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
119825492  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
119820512  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
119812910  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
119825311  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
119813232  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
119812065  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
119828047  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
119802238  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
119808239  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
119800726  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
119812782  26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
119818979  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
119820678  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
119814373  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
119815375  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
119824418  Nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
119827467  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
119799550  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
119813642  Cdk5r1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
119800861  Slc39a1; LOW QUALITY PROTEIN: zinc transporter ZIP1 [KO:K14709]
119821635  Slc39a3; zinc transporter ZIP3 [KO:K14709]
119800113  Slc39a2; zinc transporter ZIP2 [KO:K14709]
119823482  Slc39a4; zinc transporter ZIP4 [KO:K14710]
119803348  Slc39a5; zinc transporter ZIP5 isoform X1 [KO:K14711]
119814217  Slc39a6; zinc transporter ZIP6 [KO:K14712]
119822750  Slc39a7; zinc transporter SLC39A7 [KO:K14713]
119800853  Slc39a8; metal cation symporter ZIP8 [KO:K14714]
119818630  Slc39a9; zinc transporter ZIP9 [KO:K14715]
119803852  Slc39a10; zinc transporter ZIP10 [KO:K14716]
119811156  Slc39a11; zinc transporter ZIP11 [KO:K14717]
119817459  Slc39a12; zinc transporter ZIP12 [KO:K14718]
119815612  Slc39a13; LOW QUALITY PROTEIN: zinc transporter ZIP13 [KO:K14719]
119799933  Slc39a14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
119822292  Slc11a2; natural resistance-associated macrophage protein 2 [KO:K21398]
119806641  Cdk5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119804312  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
119801474  Dkk2; dickkopf-related protein 2 [KO:K02165]
119811063  Dkk4; dickkopf-related protein 4 [KO:K02165]
119805949  Dkk1; dickkopf-related protein 1 [KO:K02165]
119824043  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
119801133  Wnt2b; protein Wnt-2b [KO:K00182]
119807630  Wnt2; protein Wnt-2 [KO:K00182]
119813159  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
119817378  Wnt4; protein Wnt-4 [KO:K00408]
119827774  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
119808280  Wnt5b; protein Wnt-5b [KO:K00444]
119821641  Wnt6; protein Wnt-6 [KO:K00445]
119808152  Wnt7a; protein Wnt-7a [KO:K00572]
119823832  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
119801469  Wnt8b; protein Wnt-8b [KO:K00714]
119815317  Wnt8a; protein Wnt-8a [KO:K00714]
119812884  Wnt9b; protein Wnt-9b [KO:K01064]
119813175  Wnt9a; protein Wnt-9a [KO:K01064]
119821609  Wnt10a; protein Wnt-10a [KO:K01357]
119823873  Wnt10b; protein Wnt-10b [KO:K01357]
119802903  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
119808392  Wnt16; protein Wnt-16 [KO:K01558]
119803883  Fzd7; frizzled-7 [KO:K02432]
119803894  Fzd1; frizzled-1 [KO:K02432]
119813185  Fzd2; frizzled-2 [KO:K02235]
119800348  Fzd3; frizzled-3 [KO:K02329]
119802675  Fzd4; frizzled-4 [KO:K02354]
119802282  Fzd8; frizzled-8 [KO:K02375]
119820296  Fzd5; frizzled-5 [KO:K02375]
119822803  Fzd6; frizzled-6 [KO:K02376]
119825464  Fzd9; frizzled-9 [KO:K02842]
119825673  Fzd10; frizzled-10 [KO:K02842]
119825088  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
119806598  Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
119822771  Csnk1e; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
119816593  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
119811174  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
119824840  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
119822495  Frat1; proto-oncogene FRAT1 [KO:K03069]
119822724  Frat2; GSK-3-binding protein FRAT2 [KO:K03096]
119802199  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
119814096  Csnk2a1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
119822509  Csnk2b; casein kinase II subunit beta [KO:K03115]
119813237  Axin1; axin-1 isoform X1 [KO:K02157]
119813003  Axin2; axin-2 [KO:K04385]
119800867  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
119815778  Apc; adenomatous polyposis coli protein [KO:K02085]
119808978  Ctnnb1; catenin beta-1 [KO:K02105]
119814283  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
119816354  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
119803441  Kif5a; kinesin heavy chain isoform X1 [KO:K10396]
119819571  Kif5c; kinesin heavy chain [KO:K10396]
119822629  Klc4; kinesin light chain 4 [KO:K10407]
119819630  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
119827138  Klc2; kinesin light chain 2 [KO:K10407]
119820796  Klc3; kinesin light chain 3 isoform X1 [KO:K10407]
119821363  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
119822305  tubulin alpha-1B chain [KO:K07374]
119822381  Tuba1a; tubulin alpha-1A chain [KO:K07374]
119822383  tubulin alpha-1C chain [KO:K07374]
119817489  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
119805855  tubulin alpha-3 chain [KO:K07374]
119806400  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
119806404  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
119806674  Tuba8; tubulin alpha-8 chain [KO:K07374]
119814720  Tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
119801749  uncharacterized protein LOC119801749 [KO:K07375]
119816178  tubulin beta-2B chain [KO:K07375]
119823163  Tubb; tubulin beta chain [KO:K07375]
119819107  Tubb4b; tubulin beta-4B chain [KO:K07375]
119825449  Tubb4a; tubulin beta-4A chain [KO:K07375]
119814018  Tubb6; tubulin beta-6 chain [KO:K07375]
119822474  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119805132  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119806667  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119805194  Nox1; NADPH oxidase 1 [KO:K08008]
119805427  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
119802703  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119811441  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
119827843  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
119822506  Tnf; tumor necrosis factor [KO:K03156]
119808459  Il6; interleukin-6 [KO:K05405]
119813991  Il1a; interleukin-1 alpha [KO:K04383]
119814887  Il1b; interleukin-1 beta [KO:K04519]
119801389  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119807720  Snca; alpha-synuclein isoform X1 [KO:K04528]
119808127  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119805421  Ins; insulin [KO:K04526]
119825604  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119820738  Irs1; insulin receptor substrate 1 [KO:K16172]
119813278  Irs2; insulin receptor substrate 2 [KO:K07187]
119824895  insulin receptor substrate 1-like [KO:K17445]
119805566  Irs4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119824755  Ulk1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
119811830  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
119823995  Atg101; autophagy-related protein 101 [KO:K19730]
119814258  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
119826166  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
119814136  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
119812489  Becn1; beclin-1 [KO:K08334]
119808826  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
119800037  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
119823226  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
119815605  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
119802023  Atg2a; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog A [KO:K17906]
119818581  Atg2b; autophagy-related protein 2 homolog B [KO:K17906]
119824978  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
119812957  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Takuma K, Yan SS, Stern DM, Yamada K
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Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
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J Pharmacol Sci 97:312-6 (2005)
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PMID:18675468
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Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
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Trends Neurosci 31:454-63 (2008)
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Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
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Neurobiol Dis 5:129-41 (1998)
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PMID:18035450
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Bojarski L, Herms J, Kuznicki J
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Calcium dysregulation in Alzheimer's disease.
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Neurochem Int 52:621-33 (2008)
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PMID:25450339
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Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
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Biochim Biophys Acta 1848:2532-46 (2015)
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Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
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Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
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Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
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Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
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Related
pathway
aamp00190  Oxidative phosphorylation
aamp03050  Proteasome
aamp04020  Calcium signaling pathway
aamp04140  Autophagy - animal
aamp04141  Protein processing in endoplasmic reticulum
aamp04210  Apoptosis
aamp04310  Wnt signaling pathway
aamp04910  Insulin signaling pathway
aamp04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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