KEGG   PATHWAY: bbub04062
Entry
bbub04062                   Pathway                                
Name
Chemokine signaling pathway - Bubalus bubalis (water buffalo)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
bbub04062  Chemokine signaling pathway
bbub04062

Other DBs
GO: 0070098
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102415247  growth-regulated protein homolog gamma [KO:K05505]
102415899  growth-regulated alpha protein [KO:K05505]
102416225  growth-regulated protein homolog beta [KO:K05505]
102414238  C-X-C motif chemokine 6 [KO:K05506]
102412933  CXCL8; interleukin-8 precursor [KO:K10030]
102415351  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
102415013  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102414674  CXCL11; C-X-C motif chemokine 11 isoform X2 [KO:K12672]
102403960  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102415138  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
102394558  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
102414909  platelet factor 4 [KO:K05407]
102415761  lymphotactin [KO:K05507]
102415426  lymphotactin [KO:K05507]
102392529  CX3CL1; fractalkine [KO:K05508]
102389875  CCL1; C-C motif chemokine 1 [KO:K05514]
102408963  C-C motif chemokine 2 [KO:K14624]
102413537  C-C motif chemokine 3 isoform X1 [KO:K05408]
102415400  C-C motif chemokine 3 [KO:K05408]
112577611  C-C motif chemokine 3 [KO:K05408]
102415065  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
102415727  regakine-1 [KO:K05408]
102414734  C-C motif chemokine 4 [KO:K12964]
102392310  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
102389105  C-C motif chemokine 8 [KO:K16596]
102408655  eotaxin [KO:K16597]
102389589  C-C motif chemokine 14 [KO:K21092]
102416057  C-C motif chemokine 23 isoform X4 [KO:K05511]
102389922  CCL16; C-C motif chemokine 16 [KO:K21093]
102392202  CCL17; C-C motif chemokine 17 [KO:K21083]
102393503  CCL19; C-C motif chemokine 19 isoform X2 [KO:K05512]
102412530  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
102393187  CCL21; C-C motif chemokine 21 [KO:K16062]
102393071  CCL22; C-C motif chemokine 22 [KO:K21095]
102402460  CCL24; C-C motif chemokine 24 [KO:K21097]
102402634  CCL25; C-C motif chemokine 25 isoform X2 [KO:K13072]
102402145  CCL26; C-C motif chemokine 26 [KO:K21096]
112577675  CCL27; C-C motif chemokine 27 [KO:K16598]
102394049  uncharacterized protein LOC102394049 [KO:K16598]
102412694  CCL28; C-C motif chemokine 28 [KO:K05513]
102398743  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
102401761  C-X-C chemokine receptor type 2 [KO:K04175]
102398115  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
102394323  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102413371  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
102390637  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
102391610  XCR1; chemokine XC receptor 1 [KO:K04193]
102393859  CX3CR1; CX3C chemokine receptor 1 isoform X4 [KO:K04192]
102393323  CCR8; C-C chemokine receptor type 8 [KO:K04183]
102395463  CCR6; C-C chemokine receptor type 6 [KO:K04181]
102416431  CCR9; C-C chemokine receptor type 9 [KO:K04184]
102389630  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102416605  CCR7; C-C chemokine receptor type 7 [KO:K04182]
102393452  CCR2; C-C chemokine receptor type 2 [KO:K04177]
123327493  C-C chemokine receptor type 5 [KO:K04180]
102392270  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102391941  C-C chemokine receptor type 1 [KO:K04176]
102392809  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102407643  CCR10; C-C chemokine receptor type 10 [KO:K04185]
102412645  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102400750  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
102415500  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
102414314  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
102414888  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102400858  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
102413668  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
102401306  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 [KO:K04630]
102409247  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
102415323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102412622  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102407976  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
102408103  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
102405387  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102407637  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102410456  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102395302  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
102404282  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102392366  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102413383  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102394691  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
102410643  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
102415198  FGR; tyrosine-protein kinase Fgr isoform X1 [KO:K08891] [EC:2.7.10.2]
102410133  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102409515  SHC1; SHC-transforming protein 1 isoform X4 [KO:K06279]
102389953  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
102411865  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
102406154  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
102394713  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102412823  SOS2; son of sevenless homolog 2 [KO:K03099]
102392913  SOS1; son of sevenless homolog 1 isoform X3 [KO:K03099]
112587129  GTPase HRas-like [KO:K02833]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102399487  NRAS; GTPase NRas isoform X2 [KO:K07828]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102401079  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102395384  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102413532  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
102399362  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
102397321  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X7 [KO:K21290]
102403175  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102391543  FOXO3; forkhead box protein O3 [KO:K09408]
102399613  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
102398886  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102394706  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
102412626  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102407178  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
102403930  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
102397938  RELA; transcription factor P65 [KO:K04735]
102414298  BAD; bcl2-associated agonist of cell death [KO:K02158]
102398502  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
102401080  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
102396554  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
102415287  VAV1; proto-oncogene vav [KO:K05730]
102412230  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
102407346  VAV2; guanine nucleotide exchange factor VAV2 isoform X4 [KO:K05730]
102392559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102393591  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102406385  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102403472  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102403922  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
102402025  RHOA; transforming protein RhoA [KO:K04513]
102398804  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
102409368  ROCK2; rho-associated protein kinase 2 isoform X4 [KO:K17388] [EC:2.7.11.1]
102406849  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102399170  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102414827  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102399967  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102400794  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102412203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102393962  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102405602  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X2 [KO:K04541]
102411670  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102402000  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
102406523  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
102410454  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102403796  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102401812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102402691  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
102396193  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102408374  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
102402143  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
102409522  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102408164  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
102389306  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
102389854  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
102389136  PTK2; focal adhesion kinase 1 isoform X16 [KO:K05725] [EC:2.7.10.2]
102397491  PXN; paxillin isoform X2 [KO:K05760]
102391781  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
102389483  CRKL; crk-like protein [KO:K04438]
102397411  CRK; adapter molecule crk isoform X1 [KO:K04438]
102411722  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102409250  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102412320  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
102405830  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
102413748  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102389945  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102400354  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
102396307  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102391415  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
102394947  RAP1A; ras-related protein Rap-1A [KO:K04353]
102400135  RAP1B; ras-related protein Rap-1b [KO:K07836]
102400131  PARD3; partitioning defective 3 homolog isoform X22 [KO:K04237]
102413018  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X3 [KO:K05731]
102407189  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102407491  PRKCD; protein kinase C delta type isoform X4 [KO:K06068] [EC:2.7.11.13]
102413685  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
102404183  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
102389645  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
102408612  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
102414435  GRK3; beta-adrenergic receptor kinase 2 isoform X3 [KO:K00910] [EC:2.7.11.15]
102412507  GRK6; G protein-coupled receptor kinase 6 isoform X3 [KO:K08291] [EC:2.7.11.16]
102389056  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
102389526  GRK4; G protein-coupled receptor kinase 4 isoform X2 [KO:K08291] [EC:2.7.11.16]
102398812  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
102408724  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
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J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
bbub04010  MAPK signaling pathway
bbub04060  Cytokine-cytokine receptor interaction
bbub04120  Ubiquitin mediated proteolysis
bbub04630  JAK-STAT signaling pathway
bbub04670  Leukocyte transendothelial migration
bbub04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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