KEGG   PATHWAY: dle05167
Entry
dle05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Delphinapterus leucas (beluga whale)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
dle05167  Kaposi sarcoma-associated herpesvirus infection
dle05167

Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111166019  C3; complement C3 isoform X1 [KO:K03990]
111173425  TLR3; toll-like receptor 3 [KO:K05401]
111165914  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
111176049  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111184753  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111173795  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111170280  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
111171121  interferon alpha-1-like [KO:K05414]
111171122  interferon alpha-1-like isoform X1 [KO:K05414]
111163101  LOW QUALITY PROTEIN: interferon alpha-8-like [KO:K05414]
111163130  interferon alpha-1-like [KO:K05414]
111180609  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
111185248  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
111186470  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
111174560  IFNB1; interferon beta [KO:K05415]
111163780  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
111163874  IFNAR2; interferon alpha/beta receptor 2 isoform X3 [KO:K05131]
111178461  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111166017  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
111171663  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111173869  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111164116  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
111174878  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
111178736  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111178738  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
111186361  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186364  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111184749  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111182897  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111180869  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
111181978  IL6; interleukin-6 [KO:K05405]
111182406  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
111174478  C-C chemokine receptor type 3 [KO:K04178]
111174480  C-C chemokine receptor type 5 [KO:K04180]
111174479  C-C chemokine receptor type 1 [KO:K04176]
111164323  CCR4; C-C chemokine receptor type 4 [KO:K04179]
111169458  CCR8; C-C chemokine receptor type 8 [KO:K04183]
111172519  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111183629  FADD; FAS-associated death domain protein [KO:K02373]
111171726  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111176587  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
111180640  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111178690  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
111180543  cytochrome c [KO:K08738]
111174575  cytochrome c-like [KO:K08738]
111174031  cytochrome c-like [KO:K08738]
111172911  cytochrome c 2 [KO:K08738]
111174197  cytochrome c-like [KO:K08738]
111175930  cytochrome c-like [KO:K08738]
111187099  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111173401  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111176656  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111179654  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111177009  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111172396  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111173552  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111170969  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111173225  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
111179110  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111183745  RELA; transcription factor p65 isoform X1 [KO:K04735]
111185755  TP53; cellular tumor antigen p53 [KO:K04451]
111178743  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111173824  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
111180943  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
111175081  RB1; retinoblastoma-associated protein [KO:K06618]
111184273  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
111163373  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
111181407  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
111166690  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
111170644  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
111171394  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
111166198  IFNGR1; interferon gamma receptor 1 [KO:K05132]
111166053  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
111170962  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
111170649  MHC class I polypeptide-related sequence B-like isoform X1 [KO:K07985]
111170722  LOW QUALITY PROTEIN: MHC class I polypeptide-related sequence B-like [KO:K07985]
111166602  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
111186557  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
111186930  UBC; polyubiquitin-C [KO:K04551]
111177424  BECN2; beclin-2 [KO:K08334]
111166353  BECN1; beclin-1 isoform X1 [KO:K08334]
111173130  ATG14; beclin 1-associated autophagy-related key regulator isoform X2 [KO:K17889]
111168878  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
111187985  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
111184255  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111177426  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
111179417  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
111187055  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111181977  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
111176690  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
111176694  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
111173828  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
111177624  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
111173161  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
111183856  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
111163963  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111178375  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111170918  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111180709  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111177332  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111181049  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111166783  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111178437  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111185128  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111183022  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111166309  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111176851  KRAS; GTPase KRas [KO:K07827]
111179996  NRAS; GTPase NRas [KO:K07828]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111173087  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
111175871  JUN; transcription factor AP-1 [KO:K04448]
111176238  FOS; proto-oncogene c-Fos [KO:K04379]
111164603  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
111186025  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
111186004  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
111173839  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111179235  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111187262  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111166652  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111185984  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111175760  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111187265  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111186813  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
111181886  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111168108  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111169265  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111169895  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111162625  CD200R1; cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
111167662  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111184199  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111184309  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
111184310  tyrosine-protein kinase HCK-like [KO:K08893] [EC:2.7.10.2]
111165865  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111186018  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111166011  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111179463  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
111184170  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111174169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111176861  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111178692  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111177758  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
111187200  CALML6; calmodulin-like protein 6 [KO:K02183]
111174794  CALM2; calmodulin-2 [KO:K02183]
111170127  calmodulin-like [KO:K02183]
111180711  CALM3; calmodulin-3 [KO:K02183]
111176162  CALM1; calmodulin-1 [KO:K02183]
111179107  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111183521  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111169035  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111186607  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111188120  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
111167284  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111186778  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111179609  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111164202  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111187634  CXCL8; interleukin-8 isoform X1 [KO:K10030]
111184673  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111187662  growth-regulated alpha protein-like [KO:K05505]
111187576  growth-regulated alpha protein-like [KO:K05505]
111187591  growth-regulated alpha protein-like [KO:K05505]
111163778  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
111186075  FGF2; fibroblast growth factor 2 [KO:K18497]
111178866  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111186344  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111173359  ANGPT2; angiopoietin-2 [KO:K05466]
111186578  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
111174651  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
111166491  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111168040  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111169438  CTNNB1; catenin beta-1 [KO:K02105]
111182442  TCF7; transcription factor 7 isoform X1 [KO:K02620]
111165393  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
111172300  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
111171490  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
111171769  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111183632  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111164391  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
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J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
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Mesri EA, Cesarman E, Boshoff C
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Kaposi's sarcoma and its associated herpesvirus.
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Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
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PMID:10799607
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Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
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PMID:17166914
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Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
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Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
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PMID:11413168
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Coscoy L, Ganem D
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
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How human tumor viruses make use of autophagy.
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Cells 1:617-30 (2012)
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PMID:10354594
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Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
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  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Trends Genet 14:144-50 (1998)
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  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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FEMS Microbiol Lett 222:155-63 (2003)
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The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
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PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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Abere B, Schulz TF
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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Sodhi A, Montaner S, Gutkind JS
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Cell Cycle 6:438-43 (2007)
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
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PMID:26192396
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Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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PMID:25187543
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
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PMID:17050609
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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PMID:16585191
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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PMID:22521915
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
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Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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PMID:14991150
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
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PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
dle04010  MAPK signaling pathway
dle04064  NF-kappa B signaling pathway
dle04110  Cell cycle
dle04115  p53 signaling pathway
dle04140  Autophagy - animal
dle04144  Endocytosis
dle04151  PI3K-Akt signaling pathway
dle04210  Apoptosis
dle04310  Wnt signaling pathway
dle04610  Complement and coagulation cascades
dle04620  Toll-like receptor signaling pathway
dle04630  JAK-STAT signaling pathway
dle04650  Natural killer cell mediated cytotoxicity
dle04668  TNF signaling pathway
KO pathway
ko05167   
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