KEGG   PATHWAY: epz05169
Entry
epz05169                    Pathway                                
Name
Epstein-Barr virus infection - Equus przewalskii (Przewalski's horse)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
epz05169  Epstein-Barr virus infection
epz05169

Organism
Equus przewalskii (Przewalski's horse) [GN:epz]
Gene
103556834  CR2; complement C3d receptor 2 [KO:K04012]
103562733  CD19; CD19 molecule [KO:K06465]
103544254  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
103544529  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
103544628  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
103540140  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
103540141  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103540143  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103540328  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
103540329  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
103541526  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
103544948  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
103542554  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
103543619  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103545686  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
103543091  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
103545626  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103543208  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
103545294  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
103553736  TLR2; toll like receptor 2 [KO:K10159]
103557961  MYD88; myeloid differentiation primary response 88 [KO:K04729]
103547487  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103545279  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103560236  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103542619  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
103548723  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103548805  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103567228  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103562903  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103543979  NF-kappa-B essential modulator-like [KO:K07210]
103546400  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103556719  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103543692  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103562469  TNF; tumor necrosis factor [KO:K03156]
103561141  IL6; interleukin 6 [KO:K05405]
103550256  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:5.6.2.6]
103559810  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
103563515  TRAF3; TNF receptor associated factor 3 [KO:K03174]
103557811  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103553835  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103567336  IRF7; interferon regulatory factor 7 [KO:K09447]
103541756  IRF3; interferon regulatory factor 3 [KO:K05411]
103558747  interferon alpha-2-like [KO:K05414]
103558748  interferon alpha-3 [KO:K05414]
103558749  interferon alpha-6-like [KO:K05414]
103558750  interferon alpha-2 [KO:K05414]
103544584  interferon alpha-14-like [KO:K05414]
103563152  interferon alpha-2-like [KO:K05414]
103563154  interferon alpha-2-like [KO:K05414]
103567855  interferon alpha-1-like [KO:K05414]
103563147  interferon beta-like [KO:K05415]
103563148  interferon beta [KO:K05415]
103563150  interferon beta-like [KO:K05415]
103549120  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103549136  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103560394  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103541709  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
103548655  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
103557548  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103564029  IRF9; interferon regulatory factor 9 [KO:K04693]
103548399  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103557130  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
103542327  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
103543308  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
103562216  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
103558553  ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
103558124  FAS; Fas cell surface death receptor [KO:K04390]
103566999  FADD; Fas associated via death domain [KO:K02373]
103565685  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103559205  BID; BH3 interacting domain death agonist [KO:K04726]
103552644  BCL2L11; BCL2 like 11 [KO:K16341]
103550767  BCL2; BCL2, apoptosis regulator [KO:K02161]
103553312  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103544222  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
103547975  cytochrome c, testis-specific [KO:K08738]
103561978  cytochrome c [KO:K08738]
103550811  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
103565016  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103549132  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103541108  uncharacterized LOC103541108 [KO:K10784]
103567401  uncharacterized LOC103567401 [KO:K10784]
103564100  uncharacterized LOC103564100 [KO:K10785]
103542083  uncharacterized LOC103542083 [KO:K10785]
103546676  CD3E; CD3e molecule [KO:K06451]
103546674  CD3G; CD3g molecule [KO:K06452]
103546675  CD3D; CD3d molecule [KO:K06450]
103551552  CD247; CD247 molecule [KO:K06453]
103543475  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
103549903  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
103558851  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
103566914  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
103561115  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
103549759  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
103554743  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
103557504  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
103550168  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
103548579  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
103551830  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
103559109  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
103549830  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
103568059  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
103547658  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
103558684  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
103543017  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
103558350  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
103567112  TAPBP; TAP binding protein [KO:K08058]
103540688  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
103550639  calreticulin-like [KO:K08057]
103542640  CALR; calreticulin [KO:K08057]
103544108  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103544263  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103544779  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
103544915  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
103544893  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103543990  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
103544101  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
103544987  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
103545903  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103545933  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
103567269  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103542270  HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751]
103542271  popy class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103545683  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103545236  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103545593  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103558321  b-2-m; beta-2-microglobulin [KO:K08055]
103558323  beta-2-microglobulin-like [KO:K08055]
103561778  SNW1; SNW domain containing 1 [KO:K06063]
103552333  SIN3A; SIN3 transcription regulator family member A [KO:K11644]
103552097  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103561341  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103562818  nuclear receptor corepressor 2-like [KO:K06065]
103552426  SAP30L; SAP30 like [KO:K19202]
103547362  SAP30; Sin3A associated protein 30 [KO:K19202]
103556257  CIR1; corepressor interacting with RBPJ, 1 [KO:K06066]
103546893  RBPJ; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
103557219  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like [KO:K06053]
103560632  HES1; hes family bHLH transcription factor 1 [KO:K06054]
103540062  FCER2; Fc fragment of IgE receptor II [KO:K06468]
103559278  RUNX3; runt related transcription factor 3 [KO:K09279]
103567860  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103556240  USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
103558340  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103557703  TP53; tumor protein p53 [KO:K04451]
103564535  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103552106  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
103543986  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
103564848  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
103566732  DDB2; damage specific DNA binding protein 2 [KO:K10140]
103563108  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103551972  TRAF5; TNF receptor associated factor 5 [KO:K09849]
103549076  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103554655  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
103552150  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103548220  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103551868  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103561550  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103560497  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103540249  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103555421  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103554685  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103558148  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
103542683  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103564558  NFKBIB; NFKB inhibitor beta [KO:K02581]
103564900  NFKBIE; NFKB inhibitor epsilon [KO:K05872]
103567795  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
103543808  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103549414  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103553980  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103567629  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103567822  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103556321  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
103563092  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103564566  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103565534  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103563198  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103559485  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103559491  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103552666  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103554172  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103565822  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
103551918  CD40; CD40 molecule [KO:K03160]
103564466  CD44; CD44 molecule (Indian blood group) [KO:K06256]
103547219  ITGAL; integrin subunit alpha L [KO:K05718]
103557245  CD58; CD58 molecule [KO:K06492]
103558066  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103544024  VIM; vimentin [KO:K07606]
103549048  TNFAIP3; TNF alpha induced protein 3 [KO:K11859] [EC:3.4.19.12]
103542314  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
103550364  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103552502  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
103565660  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103548480  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
103552260  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103562625  uncharacterized LOC103562625 [KO:K06856]
103562621  putative V-set and immunoglobulin domain-containing protein 7 [KO:K06856]
103542797  BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
103552060  BLNK; B-cell linker [KO:K07371]
103558212  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
103563536  S-phase kinase-associated protein 2 [KO:K03875]
103552733  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
103567717  CCND2; cyclin D2 [KO:K10151]
103563494  CCND3; cyclin D3 [KO:K10152]
103553644  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103549196  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103563383  CCNA1; cyclin A1 [KO:K06627]
103559559  CCNA2; cyclin A2 [KO:K06627]
103556279  CCNE1; cyclin E1 [KO:K06626]
103567628  CCNE2; cyclin E2 [KO:K06626]
103560212  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103549440  RB1; RB transcriptional corepressor 1 [KO:K06618]
103541516  E2F1; E2F transcription factor 1 [KO:K17454]
103551301  E2F2; E2F transcription factor 2 [KO:K09389]
103549781  E2F3; E2F transcription factor 3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
epz03050  Proteasome
epz04010  MAPK signaling pathway
epz04020  Calcium signaling pathway
epz04064  NF-kappa B signaling pathway
epz04110  Cell cycle
epz04115  p53 signaling pathway
epz04210  Apoptosis
epz04612  Antigen processing and presentation
epz04620  Toll-like receptor signaling pathway
epz04622  RIG-I-like receptor signaling pathway
epz04630  JAK-STAT signaling pathway
epz04662  B cell receptor signaling pathway
KO pathway
ko05169   
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