KEGG   PATHWAY: etf05417
Entry
etf05417                    Pathway                                
Name
Lipid and atherosclerosis - Echinops telfairi (small Madagascar hedgehog)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
etf05417  Lipid and atherosclerosis
etf05417

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101640837  APOB; apolipoprotein B-100 [KO:K14462]
101661860  APOA4; apolipoprotein A-IV [KO:K08760]
101640718  APOA1; apolipoprotein A-I [KO:K08757]
101646129  LDLR; low-density lipoprotein receptor [KO:K12473]
101644753  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101656920  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101657534  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101646611  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101644765  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101646711  BAX; apoptosis regulator BAX [KO:K02159]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101644838  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101659262  bcl-2-like protein 1 [KO:K04570]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101657497  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101652544  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
101648095  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
101657008  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
123522305  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101653603  CD40LG; CD40 ligand [KO:K03161]
101661225  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101644960  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101645270  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101645590  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101646399  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101640739  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101654504  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
101658151  cytochrome b-245 light chain [KO:K08009]
101649411  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101657587  NCF4; LOW QUALITY PROTEIN: neutrophil cytosol factor 4 [KO:K08012]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101659376  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101656698  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101647011  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101663385  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101656124  FOS; proto-oncogene c-Fos [KO:K04379]
101656959  JUN; transcription factor AP-1 [KO:K04448]
101641002  C-C motif chemokine 2-like isoform X1 [KO:K14624]
101662141  monocyte chemotactic protein 1B-like [KO:K14624]
101651441  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101664548  CXCL8; interleukin-8 [KO:K10030]
101639675  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101643832  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
101657745  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101656204  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101653430  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101653940  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101663870  RELA; transcription factor p65 [KO:K04735]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101647112  SELE; E-selectin [KO:K06494]
101648367  P-selectin [KO:K06496]
101651428  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
101656613  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101657229  stromelysin-2 [KO:K01394] [EC:3.4.24.17]
101662935  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101639333  IL1B; interleukin-1 beta [KO:K04519]
123522712  interleukin-6-like [KO:K05405]
101644240  IL6; interleukin-6 [KO:K05405]
101654642  TNF; tumor necrosis factor [KO:K03156]
101657295  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
101658382  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101660675  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101659653  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101660593  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
101639818  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101644845  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101662815  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
101649746  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101650153  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
101639274  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101656459  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
101642841  HSP90B1; endoplasmin [KO:K09487]
101643417  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
123522309  lipopolysaccharide-binding protein-like [KO:K05399]
101647583  lipopolysaccharide-binding protein [KO:K05399]
101652025  monocyte differentiation antigen CD14-like [KO:K04391]
101652337  monocyte differentiation antigen CD14-like [KO:K04391]
101645681  LY96; lymphocyte antigen 96 [KO:K05400]
101660600  TLR4; toll-like receptor 4 [KO:K10160]
101642196  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
101644448  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101643108  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
101652271  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101658809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101649684  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101642439  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101647452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101656238  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101651170  TIR domain-containing adapter molecule 2 [KO:K05409]
101649346  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
115873309  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
101663779  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101644883  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101652197  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
101651972  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
101647812  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101649686  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101647709  IRF7; interferon regulatory factor 7 [KO:K09447]
101651495  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101650862  interferon alpha-2-like [KO:K05414]
101650550  IFNB1; interferon beta [KO:K05415]
101659291  CD36; platelet glycoprotein 4 [KO:K06259]
101656886  PPARG; peroxisome proliferator-activated receptor gamma isoform X3 [KO:K08530]
101655182  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101641553  RXRB; retinoic acid receptor RXR-beta [KO:K08525]
101661320  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101662820  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101647889  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
101638863  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101639268  VAV1; proto-oncogene vav [KO:K05730]
101656425  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101664124  TLR6; toll-like receptor 6 [KO:K10169]
101661777  RAP1A; ras-related protein Rap-1A [KO:K04353]
101659498  RAP1B; ras-related protein Rap-1b [KO:K07836]
101664314  ras-related protein Rap-1b-like [KO:K07836]
101641765  ras-related protein Rap-1b [KO:K07836]
101645531  CCL5; C-C motif chemokine 5 [KO:K12499]
101645851  C-C motif chemokine 3 [KO:K05408]
101648039  growth-regulated protein homolog gamma-like [KO:K05505]
101647727  growth-regulated protein homolog gamma-like [KO:K05505]
101641618  IL12A; interleukin-12 subunit alpha [KO:K05406]
101650484  IL12B; interleukin-12 subunit beta [KO:K05425]
101662492  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
105978242  IL18; interleukin-18 [KO:K05482]
101655317  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101659622  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101652164  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101647173  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101654141  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101641434  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101639489  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101650311  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101660158  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101643556  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101645193  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101654999  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101643958  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
101650589  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
101660660  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
101660779  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101653570  caspase-1 [KO:K01370] [EC:3.4.22.36]
101663976  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
101661509  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101641174  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101639478  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101664022  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101651304  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101650582  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101647679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101656854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101651012  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
115871000  calmodulin-A-like [KO:K02183]
101651650  neo-calmodulin-like [KO:K02183]
101662569  CALML6; calmodulin-like protein 6 [KO:K02183]
101656820  CALM3; calmodulin-3 [KO:K02183]
101638094  calmodulin-alpha-like [KO:K02183]
101650375  CALML3; calmodulin-like protein 3 [KO:K02183]
101662916  CALML5; calmodulin-like protein 5 [KO:K02183]
101654870  CALM1; calmodulin-1 [KO:K02183]
101649322  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101643468  CALM2; calmodulin-2 [KO:K02183]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101660901  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101647023  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101655233  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101659226  BID; BH3-interacting domain death agonist [KO:K04726]
101661288  cytochrome c, testis-specific [KO:K08738]
101650600  cytochrome c-like [KO:K08738]
101656765  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101657187  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
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Related
pathway
etf04020  Calcium signaling pathway
etf04115  p53 signaling pathway
etf04141  Protein processing in endoplasmic reticulum
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04620  Toll-like receptor signaling pathway
etf04621  NOD-like receptor signaling pathway
etf04668  TNF signaling pathway
etf04670  Leukocyte transendothelial migration
etf04975  Fat digestion and absorption
etf04979  Cholesterol metabolism
etf05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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