KEGG   PATHWAY: fab04010
Entry
fab04010                    Pathway                                
Name
MAPK signaling pathway - Ficedula albicollis (collared flycatcher)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
fab04010  MAPK signaling pathway
fab04010

Other DBs
GO: 0000165
Organism
Ficedula albicollis (collared flycatcher) [GN:fab]
Gene
101812454  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
101815051  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
101819434  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
101806626  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
101817703  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
101814377  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
101815155  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
101806599  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
101821759  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
101820977  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
101819244  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
101821271  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
101816433  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
101815577  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
101811107  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
101815605  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
101810133  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
101810094  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
101810491  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
101810381  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
101810689  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
101821736  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101810891  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
101820883  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
101818259  GNA12; G protein subunit alpha 12 [KO:K04346]
101807832  GNG12; G protein subunit gamma 12 [KO:K04347]
101807808  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101818111  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
101813689  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
101820532  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
101821935  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
101810969  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
101821862  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
101810860  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
101805788  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
101815429  NF1; neurofibromin 1 [KO:K08052]
101809092  RASA1; RAS p21 protein activator 1 [KO:K04352]
101811590  RASA2; RAS p21 protein activator 2 [KO:K08053]
101806584  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
101812484  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
101819290  EGF; epidermal growth factor [KO:K04357]
101808722  EREG; epiregulin [KO:K09784]
101809051  AREG; amphiregulin [KO:K09782]
101817673  FGF1; fibroblast growth factor 1 [KO:K18496]
101807010  FGF2; fibroblast growth factor 2 [KO:K18497]
101814778  FGF9; fibroblast growth factor 9 [KO:K04358]
101816520  FGF7; fibroblast growth factor 7 [KO:K04358]
101813182  FGF18; fibroblast growth factor 18 [KO:K04358]
101816411  FGF10; fibroblast growth factor 10 [KO:K04358]
101817706  FGF6; fibroblast growth factor 6 [KO:K04358]
101807954  FGF3; fibroblast growth factor 3 [KO:K04358]
101807377  FGF20; fibroblast growth factor 20 [KO:K04358]
101805762  FGF22; fibroblast growth factor 22 [KO:K04358]
101806288  FGF16; fibroblast growth factor 16 [KO:K04358]
101807018  FGF4; fibroblast growth factor 4 [KO:K04358]
101811386  FGF8; fibroblast growth factor 8 [KO:K04358]
101808144  FGF19; fibroblast growth factor 19 [KO:K22603]
101818832  FGF23; fibroblast growth factor 23 [KO:K22428]
101812533  NGF; nerve growth factor [KO:K02582]
101819815  BDNF; brain derived neurotrophic factor [KO:K04355]
101816160  NTF3; neurotrophin 3 [KO:K04356]
101812165  INS; insulin [KO:K04526]
101808710  IGF1; insulin like growth factor 1 [KO:K05459]
101812363  IGF2; insulin like growth factor 2 [KO:K13769]
101810376  PDGFA; platelet derived growth factor subunit A [KO:K04359]
101815450  PDGFB; platelet derived growth factor subunit B [KO:K17386]
101806397  PDGFD; platelet derived growth factor D [KO:K05450]
101808607  PDGFC; platelet derived growth factor C [KO:K05450]
101815683  CSF1; colony stimulating factor 1 [KO:K05453]
101814650  KITLG; KIT ligand [KO:K05461]
101806742  VEGFA; vascular endothelial growth factor A [KO:K05448]
101814975  VEGFD; vascular endothelial growth factor D [KO:K05449]
101821523  VEGFC; vascular endothelial growth factor C [KO:K05449]
101810717  HGF; hepatocyte growth factor [KO:K05460]
101807818  ANGPT1; angiopoietin 1 [KO:K05465]
101819552  ANGPT2; angiopoietin 2 [KO:K05466]
101817039  ANGPT4; angiopoietin 4 [KO:K05467]
101809438  EFNA5; ephrin A5 [KO:K05462]
101809361  ephrin-A3-like [KO:K05462]
101810702  EFNA2; ephrin A2 [KO:K05462]
101813921  GDNF; glial cell derived neurotrophic factor [KO:K05452]
101807261  ARTN; artemin [KO:K25415]
101818290  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101818019  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
101808540  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
101822220  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101812169  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101812160  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101814756  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101810901  NGFR; nerve growth factor receptor [KO:K02583]
101810326  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
101810339  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
101813861  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101819893  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101820996  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101809926  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101809748  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101812754  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
101807614  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
101806396  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
101808610  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
101808166  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
101821250  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
101822032  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
101812140  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
101816420  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
101812108  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
101812321  GRB2; growth factor receptor bound protein 2 [KO:K04364]
101809111  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
101818186  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
101811520  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
101809651  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
101813585  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
101816569  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
101818393  MRAS; muscle RAS oncogene homolog [KO:K07831]
101806469  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
101816261  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101816905  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101820507  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101814604  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
101815088  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101806775  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
101809741  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
101809086  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
101818045  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
101815005  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
101816325  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
101814204  ATF4; activating transcription factor 4 [KO:K04374]
101805694  ELK4; ELK4, ETS transcription factor [KO:K04376]
101819732  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
101819935  SRF; serum response factor [KO:K04378]
101807505  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
101818271  MAPT; microtubule associated protein tau [KO:K04380]
101819192  STMN1; stathmin 1 [KO:K04381]
101816188  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
101815404  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
101821661  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
101821460  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
101815208  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
101822250  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101822056  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
101821861  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
101821258  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
101816706  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101819115  IL1B; interleukin-1 beta [KO:K04519]
101818496  TGFB1; transforming growth factor beta-1 [KO:K13375]
101814341  TGFB2; transforming growth factor beta 2 [KO:K13376]
101809258  TGFB3; transforming growth factor beta 3 [KO:K13377]
101821296  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
101815105  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
101816129  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
101809241  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
101811048  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
101808986  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
101820749  FASLG; Fas ligand [KO:K04389]
101806294  FAS; Fas cell surface death receptor [KO:K04390]
101821415  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101808708  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
101821880  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
101806194  CDC42; cell division cycle 42 [KO:K04393]
101809680  TRADD; TNFRSF1A associated via death domain [KO:K03171]
101808212  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
101807272  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
101805645  MYD88; myeloid differentiation primary response 88 [KO:K04729]
101816877  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101817601  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
101821221  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
101806997  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
101808905  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
101809312  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
101816103  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
101816644  NRK; Nik related kinase [KO:K04407] [EC:2.7.11.1]
101820258  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
101810304  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
101805689  STK4; serine/threonine kinase 4 [KO:K04411]
101814337  STK3; serine/threonine kinase 3 [KO:K04412]
101819414  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101807669  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101811653  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101817004  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
101813992  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101812702  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
101816945  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101807474  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101812912  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101810116  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
101813811  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101814532  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101814940  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
101808561  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
101814112  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
101822010  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101812216  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
101809415  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101819388  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101807504  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
101809581  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
101815668  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
101808629  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
101807715  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
101812410  ARRB1; arrestin beta 1 [KO:K04439]
101809052  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101819306  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101817339  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101819980  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101817434  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101807358  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101814783  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101806570  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101806698  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101818385  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
101817573  M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
101811894  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
101811207  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
101816255  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
101812575  ATF2; activating transcription factor 2 [KO:K04450]
101810608  MAX; MYC associated factor X [KO:K04453]
101809833  MEF2C; myocyte enhancer factor 2C [KO:K04454]
101805999  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
101819472  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101814876  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101807578  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
101810722  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
101807075  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101820962  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101821078  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101820672  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101811455  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101807181  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101821126  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101813908  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101810587  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101812096  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101815886  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101817651  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
101809079  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
101806754  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
101815546  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
101806540  mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
101809771  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101813386  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101812706  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
101809821  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101821038  uncharacterized LOC101821038 [KO:K07210]
101817298  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
101815528  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
101808344  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
fab04070  Phosphatidylinositol signaling system
fab04110  Cell cycle
fab04115  p53 signaling pathway
fab04210  Apoptosis
fab04310  Wnt signaling pathway
KO pathway
ko04010   
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