KEGG   PATHWAY: ggo05169
Entry
ggo05169                    Pathway                                
Name
Epstein-Barr virus infection - Gorilla gorilla gorilla (western lowland gorilla)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
ggo05169  Epstein-Barr virus infection
ggo05169

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101139118  CR2; complement receptor type 2 isoform X2 [KO:K04012]
101138456  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
101128237  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101133052  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 [KO:K06752]
101133995  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
101134815  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
101137108  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
101139685  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
101140024  MHC-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101141025  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101141395  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109027175  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
101131235  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
101140641  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101132303  HLA class II histocompatibility antigen, DR beta 3 chain [KO:K06752]
115935014  HLA class II histocompatibility antigen, DRB1 beta chain isoform X3 [KO:K06752]
134758703  HLA class II histocompatibility antigen, DR beta 3 chain-like [KO:K06752]
101128447  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
101141837  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101141826  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101140803  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101152087  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101138846  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
101126531  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101144707  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
101137405  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101141659  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101145841  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115932121  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
101128204  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101153465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101150285  RELA; transcription factor p65 isoform X1 [KO:K04735]
101151687  IL6; interleukin-6 isoform X1 [KO:K05405]
101135326  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
101129182  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101138038  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101125384  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101138881  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
101144709  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
101139336  interferon alpha-16 [KO:K05414]
101140412  interferon alpha-5 [KO:K05414]
101142673  interferon alpha-1/13 [KO:K05414]
101142301  IFNA8; interferon alpha-8 [KO:K05414]
101141176  IFNA6; interferon alpha-6 [KO:K05414]
101141543  interferon alpha-1/13 [KO:K05414]
101141916  IFNA2; interferon alpha-2 [KO:K05414]
101137870  IFNA21; interferon alpha-21 [KO:K05414]
101138981  interferon alpha-17 [KO:K05414]
101139713  interferon alpha-14 [KO:K05414]
115935827  interferon alpha-4 [KO:K05414]
115935829  interferon alpha-17 [KO:K05414]
115935831  interferon alpha-10-like [KO:K05414]
115935832  interferon alpha-7 [KO:K05414]
115935833  interferon alpha-7 [KO:K05414]
115935834  interferon alpha-7 [KO:K05414]
134756937  interferon alpha-17-like [KO:K05414]
101137136  IFNB1; interferon beta [KO:K05415]
101141158  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101140784  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101133331  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101129051  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
101131770  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X3 [KO:K11220]
101146695  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101146951  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
101133221  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101128307  OAS1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
101129249  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X2 [KO:K14216] [EC:2.7.7.84]
101128904  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101147442  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101152441  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
101134274  FADD; FAS-associated death domain protein [KO:K02373]
101138898  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101142032  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101149097  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
101136123  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101152769  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
101135431  cytochrome c [KO:K08738]
101152462  cytochrome c-like [KO:K08738]
101129170  cytochrome c-like [KO:K08738]
109025909  cytochrome c [KO:K08738]
109027916  cytochrome c-like [KO:K08738]
115932158  cytochrome c-like [KO:K08738]
101146129  cytochrome c, somatic-like [KO:K08738]
129524120  cytochrome c-like [KO:K08738]
129527250  cytochrome c-like [KO:K08738]
129526436  cytochrome c-like [KO:K08738]
129526136  cytochrome c-like [KO:K08738]
115933428  cytochrome c-like [KO:K08738]
101135722  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101130414  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101126742  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101149676  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
101151025  T-cell surface glycoprotein CD3 gamma chain isoform X2 [KO:K06452]
101150395  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
101133929  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
101139085  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101148521  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101135054  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101153204  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
101145965  26S proteasome regulatory subunit 10B-like [KO:K03064]
101128863  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A [KO:K03065]
101152961  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101153440  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101143222  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101126621  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
101147218  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101151153  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
101126869  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101126459  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101154371  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101138477  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101153136  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
101152290  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
109026848  26S proteasome complex subunit SEM1-like [KO:K10881]
101135419  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
101135772  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
101149497  TAPBP; tapasin isoform X3 [KO:K08058]
101129137  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101124269  LOW QUALITY PROTEIN: protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
101149397  CALR; calreticulin [KO:K08057]
101153360  patr class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
101141279  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-A*0501 alpha chain [KO:K06751]
101143843  MHC-G; HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101142998  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain isoform X2 [KO:K06751]
101142134  LOW QUALITY PROTEIN: putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
115930068  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
101143108  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101143844  class I histocompatibility antigen, Gogo-B*0201 alpha chain isoform X2 [KO:K06751]
101132159  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
101153091  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
101150925  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
101151959  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
109023024  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101126980  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
101149390  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
101129246  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
101138918  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
101138720  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
101137927  HES1; transcription factor HES-1 [KO:K06054]
101150450  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
101137492  RUNX3; runt-related transcription factor 3 isoform X2 [KO:K09279]
101137026  MYC; myc proto-oncogene protein [KO:K04377]
101152862  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [KO:K11838] [EC:3.4.19.12]
101129964  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
101133524  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
101126640  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
101140270  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
101131508  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101146783  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101128036  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101137568  POLK; DNA polymerase kappa isoform X3 [KO:K03511] [EC:2.7.7.7]
101130440  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101147819  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101131033  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
101146975  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101149500  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
101144571  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
101154090  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101143954  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101124339  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X4 [KO:K04431] [EC:2.7.12.2]
101152026  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101124033  MAPK8; mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101133141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101144745  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101153833  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101145420  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101142374  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
101134492  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101134843  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101148438  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
101152640  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
101145729  JUN; transcription factor Jun [KO:K04448]
101132747  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
109025377  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X3 [KO:K01510] [EC:3.6.1.5]
101132716  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
101126651  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
101144155  CD44; CD44 antigen isoform X7 [KO:K06256]
101124268  CD58; lymphocyte function-associated antigen 3 isoform X5 [KO:K06492]
101127502  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
101137880  VIM; vimentin [KO:K07606]
101149274  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
101135038  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101145340  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
101138129  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101129022  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
115930559  uncharacterized protein LOC115930559 [KO:K06856]
101133851  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
109023154  Ig heavy chain Mem5-like isoform X1 [KO:K06856]
101141049  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
101135942  BLNK; B-cell linker protein isoform X1 [KO:K07371]
101133643  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101134461  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
101147653  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101130447  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101144860  G1/S-specific cyclin-D1-like [KO:K04503]
101139749  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101130628  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101147065  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
109023121  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101130228  CCNA2; cyclin-A2 [KO:K06627]
101136457  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101153263  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101134470  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101134769  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101133237  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
101137595  E2F1; transcription factor E2F1 [KO:K17454]
101138211  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
101138770  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101144465  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101153929  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
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Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
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Clin Cancer Res 17:3056-63 (2011)
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Reference
PMID:21429244
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Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
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Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
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Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
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MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
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Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
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Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
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Kang H, Kiess A, Chung CH
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Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
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PMID:29932446
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Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
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Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
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El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
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Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
ggo03050  Proteasome
ggo04010  MAPK signaling pathway
ggo04020  Calcium signaling pathway
ggo04064  NF-kappa B signaling pathway
ggo04110  Cell cycle
ggo04115  p53 signaling pathway
ggo04210  Apoptosis
ggo04612  Antigen processing and presentation
ggo04620  Toll-like receptor signaling pathway
ggo04622  RIG-I-like receptor signaling pathway
ggo04630  JAK-STAT signaling pathway
ggo04662  B cell receptor signaling pathway
KO pathway
ko05169   
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