KEGG   PATHWAY: ko05022
Entry
ko05022                     Pathway                                
Name
Pathways of neurodegeneration - multiple diseases
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ko05022  Pathways of neurodegeneration - multiple diseases
ko05022

Orthology
K04520  amyloid beta A4 protein
K04380  microtubule-associated protein tau
K04528  alpha-synuclein
K23600  TAR DNA-binding protein 43
K13098  RNA-binding protein FUS
K04565  superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
K23625  ataxin 2/2L
K04533  huntingtin
K23616  ataxin 1/1L
K11863  Ataxin-3 [EC:3.4.22.-]
K05634  prion protein
K04129  muscarinic acetylcholine receptor M1
K04131  muscarinic acetylcholine receptor M3
K04133  muscarinic acetylcholine receptor M5
K23932  spectrin beta, non-erythrocytic 2
K04603  metabotropic glutamate receptor 1
K04604  metabotropic glutamate receptor 5
K04634  guanine nucleotide-binding protein G(q) subunit alpha
K04556  parkin [EC:2.3.2.31]
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K19662  classical protein kinase C beta type [EC:2.7.11.13]
K19663  classical protein kinase C gamma type [EC:2.7.11.13]
K04966  transient receptor potential cation channel subfamily C member 3
K20719  sigma non-opioid intracellular receptor
K04958  inositol 1,4,5-triphosphate receptor type 1
K04959  inositol 1,4,5-triphosphate receptor type 2
K04960  inositol 1,4,5-triphosphate receptor type 3
K04961  ryanodine receptor 1
K04962  ryanodine receptor 2
K04963  ryanodine receptor 3
K15840  proenkephalin B (prodynorphin)
K11828  discs large protein 4
K05208  glutamate receptor ionotropic, NMDA 1
K05209  glutamate receptor ionotropic, NMDA 2A
K05210  glutamate receptor ionotropic, NMDA 2B
K05211  glutamate receptor ionotropic, NMDA 2C
K05212  glutamate receptor ionotropic, NMDA 2D
K05197  glutamate receptor 1
K05198  glutamate receptor 2
K05199  glutamate receptor 3
K05200  glutamate receptor 4
K04849  voltage-dependent calcium channel N type alpha-1B
K04850  voltage-dependent calcium channel L type alpha-1C
K04851  voltage-dependent calcium channel L type alpha-1D
K04853  voltage-dependent calcium channel L type alpha-1F
K04857  voltage-dependent calcium channel L type alpha-1S
K04560  syntaxin 1A
K04809  nicotinic acetylcholine receptor alpha-7
K05853  P-type Ca2+ transporter type 2A [EC:7.2.2.10]
K04505  presenilin 1 [EC:3.4.23.-]
K04522  presenilin 2 [EC:3.4.23.-]
K11519  Derlin-1
K13525  transitional endoplasmic reticulum ATPase
K02927  ubiquitin-large subunit ribosomal protein L40e
K02977  ubiquitin-small subunit ribosomal protein S27Ae
K04551  ubiquitin B
K08770  ubiquitin C
K02730  20S proteasome subunit alpha 1 [EC:3.4.25.1]
K02726  20S proteasome subunit alpha 2 [EC:3.4.25.1]
K02728  20S proteasome subunit alpha 3 [EC:3.4.25.1]
K02731  20S proteasome subunit alpha 4 [EC:3.4.25.1]
K02729  20S proteasome subunit alpha 5 [EC:3.4.25.1]
K02725  20S proteasome subunit alpha 6 [EC:3.4.25.1]
K02727  20S proteasome subunit alpha 7 [EC:3.4.25.1]
K02738  20S proteasome subunit beta 1 [EC:3.4.25.1]
K02739  20S proteasome subunit beta 2 [EC:3.4.25.1]
K02735  20S proteasome subunit beta 3 [EC:3.4.25.1]
K02734  20S proteasome subunit beta 4 [EC:3.4.25.1]
K02737  20S proteasome subunit beta 5 [EC:3.4.25.1]
K02732  20S proteasome subunit beta 6 [EC:3.4.25.1]
K02736  20S proteasome subunit beta 7 [EC:3.4.25.1]
K03061  26S proteasome regulatory subunit T1
K03062  26S proteasome regulatory subunit T2
K03063  26S proteasome regulatory subunit T3
K03064  26S proteasome regulatory subunit T4
K03065  26S proteasome regulatory subunit T5
K03066  26S proteasome regulatory subunit T6
K03028  26S proteasome regulatory subunit N1
K03032  26S proteasome regulatory subunit N2
K03033  26S proteasome regulatory subunit N3
K06693  26S proteasome regulatory subunit N4
K03035  26S proteasome regulatory subunit N5
K03036  26S proteasome regulatory subunit N6
K03037  26S proteasome regulatory subunit N7
K03038  26S proteasome regulatory subunit N8
K03039  26S proteasome regulatory subunit N9
K03029  26S proteasome regulatory subunit N10
K03030  26S proteasome regulatory subunit N11
K03031  26S proteasome regulatory subunit N12
K06691  26S proteasome regulatory subunit N13
K10881  26 proteasome complex subunit DSS1
K05611  ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]
K03178  ubiquitin-activating enzyme E1 [EC:6.2.1.45]
K10698  ubiquitin-activating enzyme E1-like [EC:6.2.1.45]
K04552  ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
K04553  ubiquitin/ISG15-conjugating enzyme E2 L6 [EC:2.3.2.23]
K04554  ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
K10578  ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
K04555  ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
K10575  ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
K04243  prosaposin receptor
K04557  septin 5
K04558  synphilin-1
K09490  endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
K10707  vesicle-associated membrane protein-associated protein B
K09054  cyclic AMP-dependent transcription factor ATF-6 alpha
K04452  DNA damage-inducible transcript 3
K09027  X box-binding protein 1
K08852  serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K03173  TNF receptor-associated factor 2 [EC:2.3.2.27]
K04426  mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04431  mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04741  caspase 12 [EC:3.4.22.-]
K04418  mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]
K08860  eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K03237  translation initiation factor 2 subunit 1
K04374  cyclic AMP-dependent transcription factor ATF-4
K05036  solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
K05688  PTEN induced putative kinase 1 [EC:2.7.11.1]
K03878  NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03942  NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K11352  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K03957  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K11351  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K03934  NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03967  NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NADH dehydrogenase (ubiquinone) 1 subunit C2
K00234  succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00411  ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414  ubiquinol-cytochrome c reductase core subunit 1
K00415  ubiquinol-cytochrome c reductase core subunit 2
K00416  ubiquinol-cytochrome c reductase subunit 6
K00417  ubiquinol-cytochrome c reductase subunit 7
K00418  ubiquinol-cytochrome c reductase subunit 8
K00419  ubiquinol-cytochrome c reductase subunit 9
K00420  ubiquinol-cytochrome c reductase subunit 10
K02262  cytochrome c oxidase subunit 3
K02256  cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261  cytochrome c oxidase subunit 2
K02263  cytochrome c oxidase subunit 4
K02264  cytochrome c oxidase subunit 5a
K02265  cytochrome c oxidase subunit 5b
K02266  cytochrome c oxidase subunit 6a
K02267  cytochrome c oxidase subunit 6b
K02268  cytochrome c oxidase subunit 6c
K02270  cytochrome c oxidase subunit 7a
K02271  cytochrome c oxidase subunit 7b
K02272  cytochrome c oxidase subunit 7c
K02273  cytochrome c oxidase subunit 8
K02132  F-type H+-transporting ATPase subunit alpha
K02133  F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02136  F-type H+-transporting ATPase subunit gamma
K02134  F-type H+-transporting ATPase subunit delta
K02135  F-type H+-transporting ATPase subunit epsilon
K02126  F-type H+-transporting ATPase subunit a
K02127  F-type H+-transporting ATPase subunit b
K02128  F-type H+-transporting ATPase subunit c
K02138  F-type H+-transporting ATPase subunit d
K02137  F-type H+-transporting ATPase subunit O
K02131  F-type H+-transporting ATPase subunit 6
K02125  F-type H+-transporting ATPase subunit 8
K02161  apoptosis regulator Bcl-2
K05862  voltage-dependent anion channel protein 1
K11518  mitochondrial import receptor subunit TOM40
K20858  calcium uniporter protein, mitochondrial
K02183  calmodulin
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K06268  serine/threonine-protein phosphatase 2B regulatory subunit
K02158  Bcl-2-antagonist of cell death
K04389  tumor necrosis factor ligand superfamily member 6
K04390  tumor necrosis factor receptor superfamily member 6
K02373  FAS-associated death domain protein
K04398  caspase 8 [EC:3.4.22.61]
K04726  BH3 interacting domain death agonist
K02159  apoptosis regulator BAX
K14021  Bcl-2 homologous antagonist/killer
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
K08669  HtrA serine peptidase 2 [EC:3.4.21.108]
K09488  TNF receptor-associated protein 1
K15040  voltage-dependent anion channel protein 2
K15041  voltage-dependent anion channel protein 3
K05863  solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K09565  peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
K08738  cytochrome c
K02084  apoptotic protease-activating factor
K04399  caspase 9 [EC:3.4.22.62]
K02187  caspase 3 [EC:3.4.22.56]
K04559  huntingtin interacting protein 1
K04638  intraflagellar transport protein 57
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
K05864  peptidyl-prolyl isomerase D [EC:5.2.1.8]
K05687  protein DJ-1 [EC:3.5.1.124]
K04570  Bcl-2-like 1 (apoptosis regulator Bcl-X)
K21356  mitofusin 1 [EC:3.6.5.-]
K06030  mitofusin 2 [EC:3.6.5.-]
K19946  optineurin
K14381  sequestosome 1
K10435  microtubule-associated protein 1 light chain
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
K12650  TRAF family member-associated NF-kappa-B activator
K23610  WD repeat-containing protein 41
K23611  guanine nucleotide exchange protein SMCR8
K23609  guanine nucleotide exchange protein C9orf72
K07901  Ras-related protein Rab-8A
K07925  Ras-related protein Rab-39B
K07874  Ras-related protein Rab-1A
K07203  serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K21357  serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08269  serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K19730  autophagy-related protein 101
K08331  autophagy-related protein 13
K17589  RB1-inducible coiled-coil protein 1
K17985  activating molecule in BECN1-regulated autophagy protein 1
K08334  beclin
K08333  phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
K17889  beclin 1-associated autophagy-related key regulator
K21246  nuclear receptor-binding factor 2
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K17906  autophagy-related protein 2
K17908  autophagy-related protein 18
K17603  zinc finger FYVE domain-containing protein 1
K04575  amyotrophic lateral sclerosis 2 protein
K07887  Ras-related protein Rab-5A
K04392  Ras-related C3 botulinum toxin substrate 1
K12192  charged multivesicular body protein 2B
K22913  phosphatidylinositol 3,5-bisphosphate 5-phosphatase [EC:3.1.3.-]
K19026  spatacsin
K03156  tumor necrosis factor superfamily, member 2
K03158  tumor necrosis factor receptor superfamily member 1A
K05141  tumor necrosis factor receptor superfamily member 1B
K02308  death-associated protein 6
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441  p38 MAP kinase [EC:2.7.11.24]
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K04569  copper chaperone for superoxide dismutase
K00432  glutathione peroxidase [EC:1.11.1.9]
K03781  catalase [EC:1.11.1.6]
K07607  peripherin
K04572  neurofilament light polypeptide
K04573  neurofilament medium polypeptide (neurofilament 3)
K04574  neurofilament heavy polypeptide
K10396  kinesin family member 5
K10407  kinesin light chain
K07374  tubulin alpha
K07375  tubulin beta
K03083  glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03097  casein kinase II subunit alpha [EC:2.7.11.1]
K03115  casein kinase II subunit beta
K04355  brain-derived neurotrophic factor
K04648  dynactin 1
K10424  dynactin 2
K10425  dynactin 3
K10426  dynactin 4
K10427  dynactin 5
K10428  dynactin 6
K16575  centractin
K16576  actin-related protein 10
K04647  huntingtin-associated protein 1
K10408  dynein axonemal heavy chain
K10410  dynein axonemal light intermediate chain 1
K10409  dynein axonemal intermediate chain 1
K11143  dynein axonemal intermediate chain 2
K10411  dynein axonemal light chain 1
K10412  dynein axonemal light chain 4
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K01367  calpain-1 [EC:3.4.22.52]
K03853  calpain-2 [EC:3.4.22.53]
K11716  cyclin-dependent kinase 5 activator 1
K02090  cyclin-dependent kinase 5 [EC:2.7.11.22]
K04397  caspase 7 [EC:3.4.22.60]
K02165  dickkopf 1/2/4
K03209  wingless-type MMTV integration site family, member 1
K00182  wingless-type MMTV integration site family, member 2
K00312  wingless-type MMTV integration site family, member 3
K00408  wingless-type MMTV integration site family, member 4
K00444  wingless-type MMTV integration site family, member 5
K00445  wingless-type MMTV integration site family, member 6
K00572  wingless-type MMTV integration site family, member 7
K00714  wingless-type MMTV integration site family, member 8
K01064  wingless-type MMTV integration site family, member 9
K01357  wingless-type MMTV integration site family, member 10
K01384  wingless-type MMTV integration site family, member 11
K01558  wingless-type MMTV integration site family, member 16
K02432  frizzled 1/7
K02235  frizzled 2
K02329  frizzled 3
K02354  frizzled 4
K02375  frizzled 5/8
K02376  frizzled 6
K02842  frizzled 9/10
K04690  frizzled
K03068  low density lipoprotein receptor-related protein 5/6
K08960  casein kinase 1, epsilon [EC:2.7.11.1]
K02353  segment polarity protein dishevelled
K03069  frequently rearranged in advanced T-cell lymphomas 1
K03096  frequently rearranged in advanced T-cell lymphomas 2
K02157  axin 1
K04385  axin 2
K02085  adenomatosis polyposis coli protein
K02105  catenin beta 1
K08957  casein kinase 1, alpha [EC:2.7.11.1]
K19722  receptor for advanced glycosylation end products
K02833  GTPase HRas
K07827  GTPase KRas
K07828  GTPase NRas
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K08008  NADPH oxidase 1
K21421  NADPH oxidase 2 [EC:1.-.-.-]
K21423  NADPH oxidase 4 [EC:1.6.3.-]
K04735  transcription factor p65
K02580  nuclear factor NF-kappa-B p105 subunit
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K11987  prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K05405  interleukin 6
K04383  interleukin 1 alpha
K04519  interleukin 1 beta
K05453  macrophage colony-stimulating factor 1
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
  Authors
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
  Title
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
  Journal
Int J Mol Sci 21:E2108 (2020)
DOI:10.3390/ijms21062108
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
ko00190  Oxidative phosphorylation
ko03050  Proteasome
ko04020  Calcium signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04142  Lysosome
ko04210  Apoptosis
ko04310  Wnt signaling pathway
ko04724  Glutamatergic synapse
ko04933  AGE-RAGE signaling pathway in diabetic complications
LinkDB

DBGET integrated database retrieval system