KEGG   PATHWAY: mlf05165
Entry
mlf05165                    Pathway                                
Name
Human papillomavirus infection - Myotis lucifugus (little brown bat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mlf05165  Human papillomavirus infection
mlf05165

Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102433775  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102417121  WNT2; protein Wnt-2 [KO:K00182]
102440610  WNT2B; LOW QUALITY PROTEIN: protein Wnt-2b [KO:K00182]
102429304  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102422483  WNT5A; protein Wnt-5a [KO:K00444]
102436468  WNT5B; protein Wnt-5b [KO:K00444]
102420490  WNT6; protein Wnt-6 [KO:K00445]
102440256  WNT7A; protein Wnt-7a [KO:K00572]
102417803  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
102427177  WNT8B; protein Wnt-8b [KO:K00714]
102427165  WNT9A; protein Wnt-9a [KO:K01064]
102417616  WNT9B; protein Wnt-9b [KO:K01064]
102425605  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
102436360  WNT10B; protein Wnt-10b [KO:K01357]
102429600  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102440107  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
102438581  FZD1; frizzled-1 [KO:K02432]
102433622  FZD7; frizzled-7 [KO:K02432]
102437539  FZD3; frizzled-3 isoform X1 [KO:K02329]
102432960  FZD4; frizzled-4 isoform X1 [KO:K02354]
102429852  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
102420951  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
102442257  FZD6; frizzled-6 [KO:K02376]
102435819  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
102424701  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
102419260  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
102428794  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
102421524  AXIN1; axin-1 isoform X1 [KO:K02157]
102432404  AXIN2; axin-2 [KO:K04385]
102438347  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
102420488  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
102441147  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102433998  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
102424129  TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
102433022  TCF7; transcription factor 7 isoform X4 [KO:K02620]
102417756  TCF7L1; transcription factor 7-like 1 [KO:K04490]
102428683  TCF7L2; transcription factor 7-like 2 isoform X5 [KO:K04491]
102418005  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
102430015  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
102426981  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102420724  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102441851  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102424113  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102422872  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
102417209  IFNB1; interferon beta [KO:K05415]
102430864  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102424403  CREBBP; CREB-binding protein isoform X4 [KO:K04498] [EC:2.3.1.48]
102420294  TADA3; transcriptional adapter 3 [KO:K11315]
102431418  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
102422076  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
102428304  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102440360  PARD3; partitioning defective 3 homolog isoform X20 [KO:K04237]
102422305  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
102418388  PARD6A; LOW QUALITY PROTEIN: partitioning defective 6 homolog alpha [KO:K06093]
102426835  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102431883  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
102439024  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102436423  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
102427560  DLG2; disks large homolog 2 isoform X2 [KO:K12075]
102434447  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
102423037  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X2 [KO:K06094]
102439485  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
102417223  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
102435830  PATJ; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
102428174  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
102426871  VWF; von Willebrand factor [KO:K03900]
102441094  THBS1; thrombospondin-1 [KO:K16857]
102431756  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
102423421  THBS4; thrombospondin-4 [KO:K04659]
102437320  COMP; cartilage oligomeric matrix protein [KO:K04659]
102435863  THBS3; thrombospondin-3 [KO:K04659]
102440437  FN1; fibronectin isoform X7 [KO:K05717]
102434359  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
102440571  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102427340  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102419751  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102428769  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
102428453  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102420284  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102443143  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102416916  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102418832  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
102436416  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
102437036  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102437344  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
102434127  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
102434641  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102419595  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102442455  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102423308  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102436659  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
102426930  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102421945  LAMA5; laminin subunit alpha-5 [KO:K06240]
106694687  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
102434140  LAMA3; laminin subunit alpha-3 [KO:K06240]
102434037  LAMA4; laminin subunit alpha-4 [KO:K06241]
102438476  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102420016  LAMB3; laminin subunit beta-3 [KO:K06244]
102438166  LAMB4; laminin subunit beta-4 [KO:K06245]
102419814  LAMC1; laminin subunit gamma-1 [KO:K05635]
102438305  LAMC2; laminin subunit gamma-2 [KO:K06246]
102434681  LAMC3; laminin subunit gamma-3 [KO:K06247]
102433247  LOW QUALITY PROTEIN: laminin subunit gamma-3-like [KO:K06247]
102422748  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
102417152  SPP1; osteopontin [KO:K06250]
102427760  VTN; vitronectin [KO:K06251]
102442551  TNN; tenascin-N [KO:K06252]
102421464  TNR; tenascin-R [KO:K06252]
102424435  TNC; tenascin isoform X3 [KO:K06252]
102442831  IBSP; bone sialoprotein 2 [KO:K06253]
102434163  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102420344  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
102441901  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102439596  ITGA4; integrin alpha-4 [KO:K06483]
102438432  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
102426340  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102427655  ITGA7; integrin alpha-7 [KO:K06583]
102422404  ITGA8; integrin alpha-8 [KO:K06584]
102438448  ITGA9; integrin alpha-9 [KO:K06585]
102432339  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102430047  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
102439153  ITGAV; integrin alpha-V [KO:K06487]
102438984  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102421777  ITGB3; integrin beta-3 [KO:K06493]
102429864  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
102424308  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
102428536  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102418373  ITGB7; integrin beta-7 [KO:K06590]
102435389  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102442955  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102427666  PXN; paxillin isoform X1 [KO:K05760]
102437558  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102419664  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102433190  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102439228  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102433075  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111824600  FADD; FAS-associated death domain protein [KO:K02373]
102439369  CASP8; LOW QUALITY PROTEIN: caspase-8 [KO:K04398] [EC:3.4.22.61]
102438419  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
102441196  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X2 [KO:K13365]
102432188  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102430803  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
102421388  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
102442817  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102431175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102423271  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
102440385  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
102437363  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
102422214  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102433629  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102428034  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102433480  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102417642  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
102432946  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
102430062  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584]
102442935  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
102440346  TSC1; hamartin [KO:K07206]
102422720  TSC2; tuberin isoform X1 [KO:K07207]
102422024  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
102441557  RHEB; GTP-binding protein Rheb [KO:K07208]
102434974  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102418433  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102429245  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
102433676  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102437326  BAK1; LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer [KO:K14021]
102437980  BAD; bcl2-associated agonist of cell death [KO:K02158]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102432268  FOXO1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
102429961  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102439094  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
102441858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
102422703  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102435083  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102431798  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102430068  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102431579  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102429544  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102440300  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102436007  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
102428375  RBL1; LOW QUALITY PROTEIN: retinoblastoma-like protein 1 [KO:K04681]
102423035  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
102433715  PSMC1; 26S proteasome regulatory subunit 4 isoform X2 [KO:K03062]
102421766  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
102442533  CCNA2; cyclin-A2 [KO:K06627]
102427709  CCNA1; cyclin-A1 [KO:K06627]
102440135  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102440870  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102436137  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102435748  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102424236  RELA; transcription factor p65 [KO:K04735]
102416898  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102434536  NFX1; transcriptional repressor NF-X1 isoform X3 [KO:K12236]
102428494  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102425617  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
102423242  CHD4; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
102430451  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
102422835  TBPL1; TATA box-binding protein-like protein 1 isoform X2 [KO:K03120]
102432460  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
102418215  TBP; TATA-box-binding protein isoform X2 [KO:K03120]
102440675  HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X10 [KO:K06751]
102442541  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
102433344  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X2 [KO:K06751]
102438185  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
102435002  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X3 [KO:K06751]
102429481  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X12 [KO:K06751]
111822980  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X3 [KO:K06751]
111822961  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
102432715  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X6 [KO:K06751]
102429581  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
102417058  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
102435927  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X1 [KO:K06751]
102431662  HLA class I histocompatibility antigen, B-18 alpha chain-like isoform X1 [KO:K06751]
102428684  HLA class I histocompatibility antigen, B-57 alpha chain-like [KO:K06751]
102418243  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
102424088  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
102440606  HLA class I histocompatibility antigen, B-54 alpha chain-like isoform X1 [KO:K06751]
102416963  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
111823006  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
102431053  HLA class I histocompatibility antigen, B-82 alpha chain-like [KO:K06751]
102442224  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
102438496  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
102441816  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751]
102418018  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102422972  HLA class I histocompatibility antigen, B-57 alpha chain-like [KO:K06751]
102424815  HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X3 [KO:K06751]
102422085  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
102424768  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
102417991  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102426059  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
102427446  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
102425415  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102439179  ATP6V1B2; V-type proton ATPase subunit B, brain isoform isoform X1 [KO:K02147]
102442571  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
102428837  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
102427644  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
102438262  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102420621  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
102425122  V-type proton ATPase subunit E 1-like isoform X1 [KO:K02150]
102427002  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102430094  V-type proton ATPase subunit G 3 [KO:K02152]
102422711  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102424885  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102434782  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102435006  LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
102419050  ATP6V0A4; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
102424559  TCIRG1; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
102421280  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102434740  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
102442810  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102423809  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
102426166  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
102430553  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102429506  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
102440366  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
102441095  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102430744  NRAS; GTPase NRas [KO:K07828]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102423775  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102437889  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
102428502  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X11 [KO:K04632]
102433989  neuroendocrine secretory protein 55-like [KO:K04632]
102437773  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102417960  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102417074  BAX; apoptosis regulator BAX [KO:K02159]
102428529  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102431250  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102416978  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
102443216  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102427186  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102421849  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102439961  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102427036  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
102417727  TUBG2; tubulin gamma-2 chain [KO:K10389]
102418360  LOW QUALITY PROTEIN: tubulin gamma-1 chain [KO:K10389]
102423265  PKM; LOW QUALITY PROTEIN: pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
102427197  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
102419381  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
102442353  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102433832  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102424662  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
102430852  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
102425810  IRF9; interferon regulatory factor 9 [KO:K04693]
102418614  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
102435546  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
102428439  interferon-induced GTP-binding protein Mx2 [KO:K14754]
102434076  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx2-like [KO:K14754]
102427199  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
102430624  ISG15; LOW QUALITY PROTEIN: ubiquitin-like protein ISG15 [KO:K12159]
102418962  JAG1; protein jagged-1 isoform X1 [KO:K06052]
106695521  NOTCH1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
102430236  NOTCH2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994]
102424223  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
102435757  PSEN1; presenilin-1 isoform X5 [KO:K04505] [EC:3.4.23.-]
102421262  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
102420819  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
102421417  MAML3; LOW QUALITY PROTEIN: mastermind-like protein 3 [KO:K06061]
102427879  MAML2; mastermind-like protein 2 [KO:K06061]
102422930  MAML1; mastermind-like protein 1 [KO:K06061]
102441013  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
102428796  RBPJL; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless-like protein [KO:K06053]
102417036  HES1; LOW QUALITY PROTEIN: transcription factor HES-1 [KO:K06054]
102435091  HES6; LOW QUALITY PROTEIN: transcription cofactor HES-6 [KO:K09087]
102435688  HES7; LOW QUALITY PROTEIN: transcription factor HES-7 [KO:K09087]
102419459  transcription cofactor HES-6-like [KO:K09087]
102421056  HES3; transcription factor HES-3 [KO:K09088]
102440048  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
102434913  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
102438851  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Sci Rep 5:13446 (2015)
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Reference
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Reference
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Related
pathway
mlf04064  NF-kappa B signaling pathway
mlf04110  Cell cycle
mlf04115  p53 signaling pathway
mlf04150  mTOR signaling pathway
mlf04151  PI3K-Akt signaling pathway
mlf04210  Apoptosis
mlf04310  Wnt signaling pathway
mlf04330  Notch signaling pathway
mlf04510  Focal adhesion
mlf04520  Adherens junction
mlf04530  Tight junction
mlf04612  Antigen processing and presentation
mlf04620  Toll-like receptor signaling pathway
mlf04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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