KEGG   PATHWAY: mmf05417
Entry
mmf05417                    Pathway                                
Name
Lipid and atherosclerosis - Molossus molossus (Pallas's mastiff bat)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
mmf05417  Lipid and atherosclerosis
mmf05417

Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118631001  APOB; apolipoprotein B-100 [KO:K14462]
118627591  APOA4; apolipoprotein A-IV [KO:K08760]
118627592  APOA1; apolipoprotein A-I [KO:K08757]
118615655  LDLR; low-density lipoprotein receptor [KO:K12473]
118624207  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
118638816  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
118627979  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
118632939  RHOA; transforming protein RhoA [KO:K04513]
118630612  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118620067  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118638701  BAX; apoptosis regulator BAX [KO:K02159]
118627989  BAD; bcl2-associated agonist of cell death [KO:K02158]
118618234  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118619009  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118642157  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118615122  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118632456  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118621119  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
118633872  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118627800  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
118637466  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
118639453  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
118618725  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
118636408  CD40LG; CD40 ligand [KO:K03161]
118643668  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
118627182  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118621128  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
118635887  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
118635805  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118641800  NCF1; neutrophil cytosol factor 1 [KO:K08011]
118638681  cytochrome b-245 light chain [KO:K08009]
118637429  NCF2; neutrophil cytosol factor 2 [KO:K08010]
118624524  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118629676  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118634787  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118626070  CDC42; cell division control protein 42 homolog [KO:K04393]
118638912  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
118633861  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118615560  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118618599  FOS; proto-oncogene c-Fos [KO:K04379]
118627223  JUN; transcription factor AP-1 [KO:K04448]
118634634  C-C motif chemokine 2-like [KO:K14624]
118615517  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
118626319  C-X-C motif chemokine 15-like [KO:K10030]
118636257  interleukin-8-like [KO:K10030]
118643469  CXCL8; interleukin-8 [KO:K10030]
118641294  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
118634140  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118641186  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118641187  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118621004  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118621005  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118637822  NRAS; GTPase NRas [KO:K07828]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118628367  RELA; transcription factor p65 [KO:K04735]
118624789  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118637866  E-selectin-like [KO:K06494]
118636936  P-selectin-like isoform X1 [KO:K06496]
118637380  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
118628226  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
118618723  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
118632575  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118630740  IL1B; interleukin-1 beta [KO:K04519]
118620458  IL6; interleukin-6 isoform X1 [KO:K05405]
118621647  TNF; tumor necrosis factor [KO:K03156]
118617421  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
118621630  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
118625121  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
118639973  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
118621036  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
118621339  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
118621340  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
118617402  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
118644016  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
118627838  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118634876  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118635330  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118621022  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118637063  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
118637778  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118624183  HSP90B1; endoplasmin [KO:K09487]
118616119  TLR2; toll-like receptor 2 [KO:K10159]
118618447  LOW QUALITY PROTEIN: lipopolysaccharide-binding protein [KO:K05399]
118618911  lipopolysaccharide-binding protein-like [KO:K05399]
118615605  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118631426  LY96; lymphocyte antigen 96 [KO:K05400]
118629497  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118640256  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
118633334  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118624132  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118636423  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
118628151  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
118623445  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118620813  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
118621083  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118632312  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118622317  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118635619  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118617230  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118642387  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
118615402  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118633499  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118618172  MIB1; E3 ubiquitin-protein ligase MIB1 isoform X1 [KO:K10645] [EC:2.3.2.27]
118643432  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
118625233  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
118637482  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
118624185  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118643167  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118639395  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118629333  interferon omega-1-like [KO:K05414]
118629850  interferon alpha-14-like [KO:K05414]
118629329  IFNB1; interferon beta [KO:K05415]
118619935  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
118633087  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
118629388  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
118621531  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
118637300  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
118631367  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118631501  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118629384  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
118643718  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
118637802  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
118626267  TLR6; toll-like receptor 6 [KO:K10169]
118637043  RAP1A; ras-related protein Rap-1A [KO:K04353]
118624733  RAP1B; ras-related protein Rap-1b [KO:K07836]
118634388  CCL5; C-C motif chemokine 5 [KO:K12499]
118634314  C-C motif chemokine 3-like [KO:K05408]
118634427  C-C motif chemokine 3 [KO:K05408]
118626364  growth-regulated protein homolog gamma-like [KO:K05505]
118643206  growth-regulated protein homolog [KO:K05505]
118643274  growth-regulated protein homolog gamma-like [KO:K05505]
118617678  IL12A; interleukin-12 subunit alpha [KO:K05406]
118615760  IL12B; interleukin-12 subunit beta [KO:K05425]
118628149  IL18; interleukin-18 [KO:K05482]
118629806  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
118637539  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
118623918  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118630894  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
118632878  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118619531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
118643618  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
118615118  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118632270  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118626254  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
118619537  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
118623538  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118633993  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118629846  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118620900  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118640291  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
118629930  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
118617877  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
118625163  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
118642512  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
118627674  caspase-1-like [KO:K01370] [EC:3.4.22.36]
118629550  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
118642806  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118617870  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118618649  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118618225  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118639385  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118618293  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
118618784  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
118628278  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118632151  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118618299  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118640095  calmodulin-like [KO:K02183]
118640172  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118617946  CALM1; calmodulin-1 [KO:K02183]
118619605  calmodulin-1 [KO:K02183]
118627560  calmodulin-like [KO:K02183]
118628169  calmodulin-1-like [KO:K02183]
118636313  calmodulin-1-like [KO:K02183]
118643424  CALML6; calmodulin-like protein 6 [KO:K02183]
118630484  CALM2; calmodulin-2 [KO:K02183]
118638252  CALM3; calmodulin-3 [KO:K02183]
118631897  calmodulin-like protein 3 [KO:K02183]
118634685  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118643595  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118632179  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118630745  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118617099  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
118643808  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
118623904  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118637768  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118625346  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118624690  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118620489  cytochrome c [KO:K08738]
118638529  cytochrome c-like [KO:K08738]
118615920  cytochrome c-like [KO:K08738]
118623170  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118626427  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118636997  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
118622705  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118632454  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
118634552  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
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Related
pathway
mmf04020  Calcium signaling pathway
mmf04115  p53 signaling pathway
mmf04141  Protein processing in endoplasmic reticulum
mmf04151  PI3K-Akt signaling pathway
mmf04210  Apoptosis
mmf04620  Toll-like receptor signaling pathway
mmf04621  NOD-like receptor signaling pathway
mmf04668  TNF signaling pathway
mmf04670  Leukocyte transendothelial migration
mmf04975  Fat digestion and absorption
mmf04979  Cholesterol metabolism
mmf05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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