KEGG   PATHWAY: mna05170
Entry
mna05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Miniopterus natalensis (Natal long-fingered bat)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
mna05170  Human immunodeficiency virus 1 infection
mna05170

Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107544013  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
107535702  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
107542570  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
107525395  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
107523767  CUL1; cullin-1 isoform X1 [KO:K03347]
107531277  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107531145  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107529376  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
107545320  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107540752  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107545079  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107543463  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107533206  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
107538557  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
107528505  PXN; paxillin isoform X1 [KO:K05760]
107535608  CRK; adapter molecule crk isoform X1 [KO:K04438]
107530545  CRKL; crk-like protein [KO:K04438]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107540994  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107530082  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107537414  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
107545508  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107533544  RELA; transcription factor p65 [KO:K04735]
107533821  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
107536966  JUN; transcription factor AP-1 [KO:K04448]
107539805  BAD; bcl2-associated agonist of cell death [KO:K02158]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107525258  KRAS; GTPase KRas [KO:K07827]
107545303  NRAS; GTPase NRas [KO:K07828]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107544926  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107544328  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107542131  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
107524904  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107529142  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
107525255  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107541588  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107542429  CALML3; calmodulin-like protein 3 [KO:K02183]
107542435  CALML5; calmodulin-like protein 5 [KO:K02183]
107536794  CALM3; calmodulin [KO:K02183]
107540147  CALML6; calmodulin-like protein 6 [KO:K02183]
107544318  CALM2; calmodulin isoform X1 [KO:K02183]
107531584  CALM1; calmodulin [KO:K02183]
107525969  CALML4; calmodulin-like protein 4 [KO:K02183]
107545505  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107545813  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107536108  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107545969  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
107541561  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107538236  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
107527885  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107531741  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107540160  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
107540939  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
107544078  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
107541113  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
107546541  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
107525867  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
107543109  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
107527185  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
107543194  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
107534609  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
107536795  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
107541861  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
107537622  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
107541673  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
107541527  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
107533406  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107533363  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
107541750  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
107539173  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107545262  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107539040  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107524443  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107527275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107525908  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
107544471  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
107536364  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
107543032  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
107526542  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
107526171  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
107542803  CFL2; cofilin-2 [KO:K05765]
107533619  CFL1; cofilin-1 [KO:K05765]
107538974  TNF; tumor necrosis factor [KO:K03156]
107531534  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
107527777  BCL2L1; bcl-2-like protein 1 [KO:K04570]
107525584  TLR2; toll-like receptor 2 [KO:K10159]
107537636  TLR4; toll-like receptor 4 [KO:K10160]
107524328  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107528202  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
107538794  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
107531990  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107531263  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
107545742  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
107533446  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107542599  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107523913  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107544156  IKBKG; NF-kappa-B essential modulator [KO:K07210]
107526117  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
107531433  IFNB1; interferon beta [KO:K05415]
107545565  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107545613  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107536041  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
107536051  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107531610  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
107530112  TMEM173; stimulator of interferon genes protein [KO:K12654]
107527094  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
107531880  IRF3; interferon regulatory factor 3 [KO:K05411]
107531231  DNA dC->dU-editing enzyme APOBEC-3B-like [KO:K18750] [EC:3.5.4.-]
107531232  DNA dC->dU-editing enzyme APOBEC-3F-like [KO:K18750] [EC:3.5.4.-]
107542147  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 [KO:K22544] [EC:3.1.5.-]
107538608  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
107538665  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
107540508  tripartite motif-containing protein 5-like isoform X1 [KO:K10648] [EC:2.3.2.27]
107534285  bone marrow stromal antigen 2-like [KO:K06731]
107544039  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
107542939  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
107537536  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107538857  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
107536208  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107542219  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
107528394  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
107529906  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107543787  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107543257  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107542171  FADD; FAS-associated death domain protein [KO:K02373]
107533931  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
107537702  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
107531901  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107541604  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
107545431  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
107536673  cytochrome c-like [KO:K08738]
107540285  cytochrome c isoform X1 [KO:K08738]
107533212  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
107531542  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
107535740  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107531685  uncharacterized protein LOC107531685 [KO:K10784]
107530780  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
107530779  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
107530792  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
107529052  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
107542669  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
107542666  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
107541594  TAPBP; tapasin [KO:K08058]
107535925  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
107541519  CALR; calreticulin [KO:K08057]
107538021  calreticulin-like [KO:K08057]
107538488  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
107538961  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107525813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107546126  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
107546127  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain-like [KO:K06751]
107528441  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
107526202  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
107524286  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
107531711  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
107533243  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
107534321  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
107526506  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
107529515  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
107526690  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
107536290  B2M; beta-2-microglobulin [KO:K08055]
107535817  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
107539552  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
107541207  CUL5; cullin-5 isoform X1 [KO:K10612]
107540191  VPRBP; protein VPRBP isoform X1 [KO:K11789] [EC:2.7.11.1]
107527694  DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
107537930  CUL4B; cullin-4B isoform X1 [KO:K10609]
107536950  CUL4A; cullin-4A isoform X1 [KO:K10609]
107541208  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
107537979  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
107530590  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
107530121  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
107531098  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
107532290  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
107537801  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
107533754  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
107541465  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
107543348  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
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Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
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HIV persistence: chemokines and their signalling pathways.
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Cytokine Growth Factor Rev 23:151-7 (2012)
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Reference
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Plasma membrane signaling in HIV-1 infection.
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Biochim Biophys Acta 1838:1132-42 (2014)
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PLoS Pathog 5:e1000520 (2009)
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PMID:22085380
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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
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J Med Chem 55:977-94 (2012)
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Reference
PMID:21321123
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Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
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J Biol Chem 286:12554-64 (2011)
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Reference
PMID:15817946
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Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
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Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
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Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
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Front Microbiol 5:177 (2014)
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Reference
PMID:22090097
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Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
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Reference
PMID:26056579
  Authors
Kumar A, Herbein G
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The macrophage: a therapeutic target in HIV-1 infection.
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Mol Cell Ther 2:10 (2014)
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Reference
PMID:20672047
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Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
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Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
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Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
PMID:28358311
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
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Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
PMID:18178131
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
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PMID:24453421
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
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  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
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PMID:21368875
  Authors
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Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
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Cell Death Dis 1:e99 (2010)
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  Authors
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Nat Rev Immunol 3:392-404 (2003)
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CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
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Viruses 3:586-612 (2011)
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  Authors
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Using death to one's advantage: HIV modulation of apoptosis.
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Leukemia 15:332-41 (2001)
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Nat Struct Mol Biol 19:661-2 (2012)
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Adv Virus Res 80:103-27 (2011)
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Mol Aspects Med 31:418-33 (2010)
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Traffic 17:976-96 (2016)
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Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
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Viruses 8:67 (2016)
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Methods Mol Biol 1170:165-227 (2014)
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Curr HIV Res 3:43-51 (2005)
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PLoS Pathog 2:e127 (2006)
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Takaori-Kondo A, Shindo K
  Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
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Front Microbiol 4:34 (2013)
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Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
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Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
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Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
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J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
mna03050  Proteasome
mna04010  MAPK signaling pathway
mna04020  Calcium signaling pathway
mna04064  NF-kappa B signaling pathway
mna04110  Cell cycle
mna04141  Protein processing in endoplasmic reticulum
mna04142  Lysosome
mna04150  mTOR signaling pathway
mna04151  PI3K-Akt signaling pathway
mna04210  Apoptosis
mna04612  Antigen processing and presentation
mna04620  Toll-like receptor signaling pathway
mna04623  Cytosolic DNA-sensing pathway
mna04668  TNF signaling pathway
mna04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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