KEGG   PATHWAY: pps04062
Entry
pps04062                    Pathway                                
Name
Chemokine signaling pathway - Pan paniscus (bonobo)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pps04062  Chemokine signaling pathway
pps04062

Other DBs
GO: 0070098
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967628  [KO:K05408]
100967770  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100967869  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100968161  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100968227  CCR10; C-C chemokine receptor type 10 [KO:K04185]
100968237  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100968258  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
100968267  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100968961  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100969111  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100969344  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8 [KO:K05858] [EC:3.1.4.11]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100969660  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100970296  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100970325  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100970465  NRAS; GTPase NRas isoform X2 [KO:K07828]
100970547  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100970679  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100970917  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100971161  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100971232  CCR2; C-C chemokine receptor type 2 [KO:K04177]
100971477  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
100971580  CCR3; C-C chemokine receptor type 3 isoform X2 [KO:K04178]
100971620  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
100971666  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100972035  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
100972068  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
100972085  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100972306  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100972356  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100972364  PXN; paxillin isoform X1 [KO:K05760]
100972624  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
100972867  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100972921  GRK4; G protein-coupled receptor kinase 4 isoform X2 [KO:K08291] [EC:2.7.11.16]
100972953  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100973015  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
100973073  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100973322  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100973431  XCR1; chemokine XC receptor 1 [KO:K04193]
100973579  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
100973798  CRKL; crk-like protein [KO:K04438]
100973850  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100974334  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100974396  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
100974798  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
100975050  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
100975214  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
100975240  CCL20; C-C motif chemokine 20 [KO:K14625]
100975544  CXCL3; C-X-C motif chemokine 3 [KO:K05505]
100975763  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
100975892  CXCL5; C-X-C motif chemokine 5 isoform X2 [KO:K05506]
100976001  CCR9; C-C chemokine receptor type 9 [KO:K04184]
100976112  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100976232  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
100976236  PPBP; platelet basic protein [KO:K10029]
100976373  FOXO3; forkhead box protein O3 [KO:K09408]
100976580  PF4; platelet factor 4 [KO:K05407]
100976587  CRK; adapter molecule crk isoform X1 [KO:K04438]
100976735  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100976904  [KO:K05505]
100976968  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100977074  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100977168  WAS; actin nucleation-promoting factor WAS [KO:K05747]
100977339  PF4V1; platelet factor 4 variant [KO:K05407]
100977683  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
100978200  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
100978242  CCL19; C-C motif chemokine 19 [KO:K05512]
100978269  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
100978320  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
100978369  CXCL8; interleukin-8 [KO:K10030]
100978487  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100978523  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100978564  CCL21; C-C motif chemokine 21 [KO:K16062]
100978643  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100978647  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X2 [KO:K04545]
100978760  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
100978961  [KO:K05507]
100979073  CCL17; C-C motif chemokine 17 [KO:K21083]
100979145  CCL1; C-C motif chemokine 1 [KO:K05514]
100979257  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
100979341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100979411  CX3CL1; fractalkine [KO:K05508]
100979427  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100979486  CCL13; C-C motif chemokine 13 [KO:K16595]
100979542  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100979742  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100979746  CCL22; C-C motif chemokine 22 [KO:K21095]
100979832  CCL8; C-C motif chemokine 8 [KO:K16596]
100980038  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100980143  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X13 [KO:K05726]
100980496  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
100980531  [KO:K16597]
100980612  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100980807  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100980934  RAP1A; ras-related protein Rap-1A [KO:K04353]
100981087  CCL2; C-C motif chemokine 2 [KO:K14624]
100981091  ITK; tyrosine-protein kinase ITK/TSK isoform X2 [KO:K07363] [EC:2.7.10.2]
100981656  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100981987  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100982509  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100982589  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100982766  VAV1; proto-oncogene vav [KO:K05730]
100983091  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100984225  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100984585  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100984694  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100984768  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100984800  GRK3; G protein-coupled receptor kinase 3 isoform X1 [KO:K00910] [EC:2.7.11.15]
100985590  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X3 [KO:K04630]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100986423  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100986660  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
100986730  [KO:K04634]
100987458  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
100987483  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100987524  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100987713  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100987766  STAT3; signal transducer and activator of transcription 3 isoform X7 [KO:K04692]
100988081  CCR8; C-C chemokine receptor type 8 [KO:K04183]
100988305  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
100988407  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
100988420  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100988429  RELA; transcription factor p65 isoform X1 [KO:K04735]
100988596  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
100988665  BAD; bcl2-associated agonist of cell death [KO:K02158]
100988790  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100988962  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
100988967  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
100989105  [KO:K11224]
100989177  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100989390  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100989733  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100989777  [KO:K04392]
100989953  PTK2; focal adhesion kinase 1 isoform X7 [KO:K05725] [EC:2.7.10.2]
100990010  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990246  CDC42; cell division control protein 42 homolog isoform X3 [KO:K04393]
100990710  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100990801  KRAS; GTPase KRas isoform X1 [KO:K07827]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100991042  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
100991116  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100991375  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
100991802  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100991936  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100991964  [KO:K12964]
100992014  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100992242  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100992309  [KO:K05408]
100992588  CCL24; C-C motif chemokine 24 isoform X2 [KO:K21097]
100992654  CCL18; C-C motif chemokine 18 [KO:K21094]
100992984  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100993003  CCL23; C-C motif chemokine 23 isoform X2 [KO:K05511]
100993077  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100993131  [KO:K04393]
100993361  SHC1; SHC-transforming protein 1 isoform X9 [KO:K06279]
100993386  HRAS; GTPase HRas isoform X1 [KO:K02833]
100993451  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100993588  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
100993600  CCL14; C-C motif chemokine 14 [KO:K21092]
100993959  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100994102  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100994152  CCL15; C-C motif chemokine 15 isoform X2 [KO:K05511]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100994514  CCL16; C-C motif chemokine 16 [KO:K21093]
100994715  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100995010  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100995028  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100995134  ADCY3; adenylate cyclase type 3 isoform X4 [KO:K08043] [EC:4.6.1.1]
100995228  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100995273  ELMO1; engulfment and cell motility protein 1 isoform X2 [KO:K12366]
100995275  CCR7; C-C chemokine receptor type 7 [KO:K04182]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100995578  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
100995642  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
100995869  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
100996017  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
112436703  CCL27; C-C motif chemokine 27 [KO:K16598]
112437196  [KO:K04545]
112437428  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
117974322  [KO:K12964]
117975026  [KO:K04542]
117976443  [KO:K05408]
117977645  [KO:K07210]
134729429  [KO:K05408]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pps04010  MAPK signaling pathway
pps04060  Cytokine-cytokine receptor interaction
pps04120  Ubiquitin mediated proteolysis
pps04630  JAK-STAT signaling pathway
pps04670  Leukocyte transendothelial migration
pps04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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