KEGG   PATHWAY: pswi04144
Entry
pswi04144                   Pathway                                
Name
Endocytosis - Pseudoliparis swirei (Mariana hadal snailfish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pswi04144  Endocytosis
pswi04144

Other DBs
GO: 0006897
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130188046  epn3a; epsin-3 isoform X1 [KO:K12471]
130188054  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X1 [KO:K05757]
130188081  dnm2a; dynamin-3 isoform X1 [KO:K23484]
130188118  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
130188150  [KO:K19475]
130188178  rab5c; ras-related protein Rab-5C [KO:K07889]
130188233  [KO:K04707] [EC:2.3.2.27]
130188276  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
130188320  epn2; epsin-2 isoform X1 [KO:K12471]
130188350  rab11fip4a; rab11 family-interacting protein 4A [KO:K12485]
130188434  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
130188662  [KO:K03283]
130188721  [KO:K05070]
130188731  snx12; sorting nexin-12 [KO:K17918]
130188801  ldlra; low density lipoprotein receptor a [KO:K12473]
130188805  [KO:K06751]
130188853  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
130188945  arf2a; ADP-ribosylation factor 2a [KO:K07937]
130188952  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
130188990  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
130189016  cyth3b; cytohesin-3 [KO:K18441]
130189022  cyth4a; cytohesin-4 [KO:K18441]
130189255  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
130189347  [KO:K12195]
130189475  dnm2b; dynamin-2 isoform X1 [KO:K23484]
130189483  mvb12a; multivesicular body subunit 12A [KO:K12186]
130189500  zfyve27; protrudin isoform X1 [KO:K19368]
130189548  [KO:K19475]
130189556  actr2a; actin-related protein 2-A [KO:K17260]
130189632  [KO:K12486]
130189656  epn3b; epsin-3 [KO:K12471]
130189738  [KO:K19475]
130189742  [KO:K19475]
130189843  grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
130189853  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
130189926  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
130189988  cyth4b; cytohesin 4b isoform X1 [KO:K18441]
130190030  [KO:K06751]
130190112  [KO:K05069]
130190226  vps37c; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
130190324  [KO:K06751]
130190336  clta; clathrin light chain A isoform X1 [KO:K04644]
130190456  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
130190505  ldlrb; low-density lipoprotein receptor isoform X1 [KO:K12473]
130190570  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
130190571  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
130190579  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
130190649  [KO:K04678] [EC:2.3.2.26]
130190780  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 [KO:K11247]
130190902  amph; amphiphysin isoform X1 [KO:K12562]
130190957  chmp1b; charged multivesicular body protein 1b [KO:K12197]
130191413  [KO:K11824]
130191597  pard6gb; par-6 family cell polarity regulator gamma b isoform X1 [KO:K06093]
130191613  [KO:K12493]
130191703  sparta; spartin a [KO:K19366]
130191738  [KO:K06751]
130191779  [KO:K18466]
130191922  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
130191964  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
130192048  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
130192276  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
130192298  [KO:K17917]
130192349  rab4a; ras-related protein Rab-4A isoform X1 [KO:K07879]
130192351  [KO:K03283]
130192387  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
130192406  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
130192409  nedd4a; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
130192557  [KO:K11824]
130192795  sh3gl3a; endophilin-A3a isoform X1 [KO:K11247]
130192833  ist1; IST1 homolog [KO:K19476]
130192892  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
130192900  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
130192936  spg21; maspardin [KO:K19367]
130193014  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
130193040  [KO:K00889] [EC:2.7.1.68]
130193053  rab11a; ras-related protein Rab-11A [KO:K07904]
130193098  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
130193273  [KO:K23605]
130193305  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
130193444  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
130193477  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
130193532  [KO:K12489]
130193549  eps15; LOW QUALITY PROTEIN: epidermal growth factor receptor substrate 15 [KO:K12472]
130193682  sh3gl1b; SH3-domain GRB2-like 1b isoform X1 [KO:K11247]
130193716  [KO:K07905]
130193748  [KO:K07901]
130193912  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
130194050  [KO:K07905]
130194090  [KO:K12472]
130194316  dnajc6; LOW QUALITY PROTEIN: putative tyrosine-protein phosphatase auxilin [KO:K09526]
130194409  [KO:K05754]
130194447  dnm3a; dynamin 3a isoform X1 [KO:K01528] [EC:3.6.5.5]
130194476  [KO:K12196]
130194622  snx1a; sorting nexin-1a isoform X1 [KO:K17917]
130194638  [KO:K10364]
130194809  chmp1a; charged multivesicular body protein 1a [KO:K12197]
130194898  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
130194905  [KO:K04388] [EC:2.7.11.30]
130194930  washc4; WASH complex subunit 4 [KO:K18465]
130195103  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
130195210  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
130195416  wash1; WASH complex subunit 1 isoform X1 [KO:K18461]
130195548  [KO:K07939]
130195678  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
130195686  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
130195765  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
130195853  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
130195873  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
130195888  tsg101a; tumor susceptibility 101a [KO:K12183]
130195891  [KO:K02833]
130195896  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
130196045  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
130196218  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
130196233  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
130196384  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
130196481  [KO:K11866] [EC:3.4.19.12]
130196500  wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
130196585  snx2; sorting nexin-2 [KO:K17917]
130196613  chmp7; charged multivesicular body protein 7 [KO:K15053]
130196626  [KO:K13712] [EC:2.7.1.68]
130196715  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
130196761  [KO:K01528] [EC:3.6.5.5]
130196843  [KO:K04500]
130196952  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
130197070  rab35b; ras-related protein Rab-35b isoform X1 [KO:K07876]
130197164  grk5l; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
130197356  sh3glb2a; endophilin-B2a isoform X1 [KO:K21269]
130197449  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
130197543  [KO:K06503]
130197616  [KO:K12472]
130197664  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
130197668  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
130197686  [KO:K11826]
130197714  [KO:K11247]
130197759  dnm3b; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
130197763  arf1; ADP-ribosylation factor 1 [KO:K07937]
130197804  [KO:K12472]
130197818  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
130198029  [KO:K04189]
130198142  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
130198195  [KO:K10396] [EC:5.6.1.3]
130198327  [KO:K00889] [EC:2.7.1.68]
130198373  [KO:K04237]
130198488  [KO:K06751]
130198510  [KO:K07901]
130198526  [KO:K07905]
130198580  rab31; ras-related protein Rab-31 [KO:K07891]
130198636  chmp5a; charged multivesicular body protein 5 [KO:K12198]
130198881  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
130198886  pard6b; partitioning defective 6 homolog beta [KO:K06093]
130198905  [KO:K12495]
130199040  [KO:K12495]
130199147  [KO:K04513]
130199188  arf3a; ADP-ribosylation factor 3a [KO:K07938]
130199203  iqsec2b; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
130199213  [KO:K10364]
130199269  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
130199341  [KO:K04393]
130199381  [KO:K04513]
130199386  [KO:K04513]
130199441  [KO:K12194]
130199456  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
130199472  [KO:K12481]
130199500  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
130199605  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
130199768  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
130200064  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
130200098  kif5aa; kinesin family member 5Aa [KO:K10396] [EC:5.6.1.3]
130200135  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
130200227  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
130200306  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
130200326  [KO:K07939]
130200690  [KO:K17919]
130200704  washc3; WASH complex subunit 3 [KO:K18463]
130200788  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
130200967  chmp3; charged multivesicular body protein 3 [KO:K12193]
130201022  rab11fip5a; rab11 family-interacting protein 1 [KO:K12484]
130201035  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
130201053  [KO:K11248]
130201204  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
130201315  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
130201364  ehd4; EH domain-containing protein 4 isoform X1 [KO:K12477]
130201484  snx6; sorting nexin-6 isoform X1 [KO:K17920]
130201520  [KO:K18584]
130201729  [KO:K17919]
130201812  vps29; vacuolar protein sorting-associated protein 29 [KO:K18467]
130201862  arf6b; ADP-ribosylation factor 6b [KO:K07941]
130201893  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
130201928  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
130202135  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 [KO:K12474]
130202252  rab10; ras-related protein Rab-10 [KO:K07903]
130202299  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
130202378  [KO:K05050]
130202408  arf6a; ADP-ribosylation factor 6a [KO:K07941]
130202622  snx3; sorting nexin-3 isoform X1 [KO:K17918]
130202684  [KO:K06751]
130202716  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
130202728  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
130202839  ehd3; EH domain-containing protein 3 [KO:K12476]
130202989  [KO:K10396] [EC:5.6.1.3]
130203220  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
130203370  [KO:K18441]
130203477  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
130203561  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
130203690  chmp2a; charged multivesicular body protein 2a [KO:K12191]
130203715  arf2b; ADP-ribosylation factor 2b [KO:K07937]
130203778  chmp6b; charged multivesicular body protein 6 [KO:K12195]
130203892  [KO:K07889]
130204062  [KO:K12494]
130204154  [KO:K18441]
130204344  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
130204554  [KO:K18584]
130204646  [KO:K10396] [EC:5.6.1.3]
130204648  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
130204735  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
130204755  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
130204807  [KO:K05050]
130204888  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
130204922  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
130205015  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
130205032  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
130205157  [KO:K08291] [EC:2.7.11.16]
130205186  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
130205239  [KO:K12494]
130205298  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
130205391  dab2; disabled homolog 2 isoform X1 [KO:K12475]
130205432  mvb12ba; multivesicular body subunit 12Ba [KO:K12186]
130205475  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
130205572  [KO:K12484]
130205706  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
130205726  [KO:K00910] [EC:2.7.11.15]
130205912  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
130205917  pard3aa; partitioning defective 3 homolog [KO:K04237]
130206000  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
130206014  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130206039  [KO:K12562]
130206043  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130206045  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
130206061  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
130206147  chmp5b; charged multivesicular body protein 5 [KO:K12198]
130206311  sh3glb1a; endophilin-B1a [KO:K11248]
130206345  tfr1b; transferrin receptor 1b [KO:K06503]
130206419  [KO:K05633] [EC:2.3.2.26]
130206528  chmp4c; charged multivesicular body protein 4c [KO:K24782]
130206605  [KO:K04361] [EC:2.7.10.1]
130206755  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
130207226  stam2; signal transducing adapter molecule 2 [KO:K04705]
130207296  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
130207346  [KO:K12484]
130207411  snx5; sorting nexin-5 [KO:K17920]
130207499  [KO:K12486]
130207534  [KO:K10396] [EC:5.6.1.3]
130207637  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
130207718  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
130207763  kif5ab; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
130207851  [KO:K12488]
130207854  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
130207902  rhoca; ras homolog family member Ca [KO:K04513]
130207967  [KO:K17848]
130208099  [KO:K04393]
130208149  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
130208155  [KO:K04513]
130208272  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
130208330  si:dkey-13a21.4; ras-related protein rab7 isoform X1 [KO:K07897]
130208377  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
130208391  [KO:K05755]
130208405  rab7a; ras-related protein Rab-7a [KO:K07897]
130208543  [KO:K07938]
130208564  [KO:K05704] [EC:2.7.10.2]
130208609  si:dkey-28n18.9; sorting nexin-6 isoform X1 [KO:K17920]
130208631  [KO:K12958]
130208632  cav3; caveolin-3 [KO:K12959]
130208667  rab22a; ras-related protein Rab-22A [KO:K07891]
130208713  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
130208737  [KO:K07897]
130208762  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
130208925  [KO:K12958]
130208945  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
130209183  cltb; clathrin light chain B isoform X1 [KO:K04645]
130209230  rab5b; ras-related protein Rab-5B [KO:K07888]
130209586  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
130209690  ehd1a; EH domain-containing protein 1a [KO:K12483]
130209729  psd2; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 2 [KO:K12494]
130209988  rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
130210096  [KO:K04439]
130210109  [KO:K12484]
130210125  [KO:K18440]
130210283  ap2s1; AP-2 complex subunit sigma [KO:K11827]
130210285  [KO:K03283]
130210356  ehd2b; EH domain-containing protein 2b [KO:K12469]
130210386  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
130210398  [KO:K12185]
130210420  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
130210458  [KO:K04646]
130210487  [KO:K18466]
130210698  zgc:162872; LOW QUALITY PROTEIN: BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
130210788  spartb; spartin b [KO:K19366]
130210995  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
130211062  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
130211371  [KO:K18439]
130211382  folr; folate receptor isoform X1 [KO:K13649]
130211479  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
130211686  zgc:101810; actin-related protein 2 [KO:K17260]
130211709  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
130211791  si:dkey-19b23.8; uncharacterized protein si:dkey-19b23.8 [KO:K12474]
130212061  arrb2b; arrestin, beta 2b [KO:K04439]
130212089  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
130212256  [KO:K11247]
130212278  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
130212698  [KO:K00889] [EC:2.7.1.68]
130212830  washc5; WASH complex subunit 5 [KO:K18464]
130212866  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
130212873  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
130212924  [KO:K07887]
130213289  [KO:K04180]
130213322  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
130213398  cyth2; cytohesin-2 [KO:K18441]
130213438  epn1a; epsin-1 isoform X1 [KO:K12471]
130213488  cdc42l; cell division cycle 42, like [KO:K04393]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pswi04060  Cytokine-cytokine receptor interaction
pswi04070  Phosphatidylinositol signaling system
pswi04130  SNARE interactions in vesicular transport
pswi04142  Lysosome
pswi04350  TGF-beta signaling pathway
KO pathway
ko04144   

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