KEGG   PATHWAY: ssc04014
Entry
ssc04014                    Pathway                                
Name
Ras signaling pathway - Sus scrofa (pig)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
ssc04014  Ras signaling pathway
ssc04014

Other DBs
GO: 0032318
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100101471  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100125828  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100126861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100127133  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100127355  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100127478  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100135662  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100135665  RELA; transcription factor p65 [KO:K04735]
100144493  NTF3; neurotrophin-3 precursor [KO:K04356]
100144499  RAB5A; ras-related protein Rab-5A [KO:K07887]
100144501  EFNA1; ephrin-A1 precursor [KO:K05462]
100151794  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
100152116  FGF6; fibroblast growth factor 6 [KO:K04358]
100152223  FGF16; fibroblast growth factor 16 [KO:K04358]
100152316  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
100152497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100152514  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
100152555  RAP1B; ras-related protein Rap-1b [KO:K07836]
100152597  PLA2G12B; group XIIB secretory phospholipase A2-like protein precursor [KO:K01047] [EC:3.1.1.4]
100152927  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100153199  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
100153248  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100153927  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100153981  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100154056  CALM1; calmodulin [KO:K02183]
100154368  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
100154449  ETS2; protein C-ets-2 [KO:K21932]
100154471  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100154522  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100154710  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100154830  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
100155163  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
100155308  [KO:K07830]
100155339  FGF23; fibroblast growth factor 23 [KO:K22428]
100155670  VEGFD; vascular endothelial growth factor D [KO:K05449]
100155720  FGF17; fibroblast growth factor 17 [KO:K04358]
100155918  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
100155923  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
100156242  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
100156321  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100156404  PGF; placenta growth factor isoform X1 [KO:K16859]
100156602  SOS2; son of sevenless homolog 2 [KO:K03099]
100157221  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100157745  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100157949  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100170851  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100192436  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100233191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100270820  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100302363  ETS1; protein C-ets-1 [KO:K02678]
100302504  FGF21; fibroblast growth factor 21 precursor [KO:K22429]
100511026  GAB1; LOW QUALITY PROTEIN: GRB2-associated-binding protein 1 [KO:K09593]
100511085  NTF4; neurotrophin-4 precursor [KO:K12457]
100511161  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100511282  KSR1; kinase suppressor of Ras 1 isoform X3 [KO:K14958]
100511446  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100511837  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100511870  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100511937  [KO:K02649]
100512036  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
100512584  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100512662  PLA2G2D; group IID secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
100513084  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
100513609  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
100513672  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100513721  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100513737  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100513811  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100513834  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100513970  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100514108  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100514115  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100514711  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
100514714  PLA2G2C; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100514741  AFDN; afadin isoform X1 [KO:K05702]
100514811  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
100515267  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100515363  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
100515414  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100515445  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X2 [KO:K05092] [EC:2.7.10.1]
100515847  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X2 [KO:K17635]
100515978  ANGPT4; angiopoietin-4 [KO:K05467]
100515992  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545]
100516199  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
100516301  FGF20; fibroblast growth factor 20 [KO:K04358]
100516546  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100516558  RRAS; ras-related protein R-Ras [KO:K07829]
100516830  RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
100517086  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100517106  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100517317  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100517816  LAT; linker for activation of T-cells family member 1 [KO:K07362]
100518074  PRKCG; protein kinase C gamma type isoform X3 [KO:K19663] [EC:2.7.11.13]
100518131  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100518179  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100518251  KRAS; GTPase KRas isoform X2 [KO:K07827]
100518595  FGF4; fibroblast growth factor 4 [KO:K04358]
100518663  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100518950  FGF19; fibroblast growth factor 19 [KO:K22603]
100518983  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X5 [KO:K08019]
100519054  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
100519127  FGF3; fibroblast growth factor 3 [KO:K04358]
100519155  RALBP1; ralA-binding protein 1 [KO:K08773]
100519209  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100519446  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100519528  CALML4; calmodulin-like 4 [KO:K02183]
100519683  RASA3; ras GTPase-activating protein 3 isoform X2 [KO:K12380]
100519764  PDGFA; platelet-derived growth factor subunit A isoform X5 [KO:K04359]
100519790  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
100520008  GNG14; uncharacterized LOC105372280 homolog [KO:K04347]
100520187  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100520314  EXOC2; exocyst complex component 2 isoform X2 [KO:K17637]
100520687  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100520715  RIN1; LOW QUALITY PROTEIN: ras and Rab interactor 1 [KO:K17638]
100521065  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
100521638  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
100521837  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
100522002  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100522202  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100522721  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100522792  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100522873  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100522926  CALM2; calmodulin [KO:K02183]
100523862  RAB5C; ras-related protein Rab-5C [KO:K07889]
100524161  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
100524280  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100524424  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
100524544  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100524587  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100525013  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100525086  FGF10; fibroblast growth factor 10 [KO:K04358]
100525104  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
100525120  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
100525129  RASAL1; LOW QUALITY PROTEIN: rasGAP-activating-like protein 1 [KO:K17632]
100525505  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100525524  SYNGAP1; LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP [KO:K17631]
100525607  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100525766  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100526136  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
100526147  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
100620407  [KO:K10784]
100620540  [KO:K07293] [EC:3.1.3.48]
100620948  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
100621275  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100621398  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100621431  [KO:K04549]
100621559  [KO:K10785]
100621675  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100621789  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100622254  RALA; ras-related protein Ral-A isoform X2 [KO:K07834]
100622320  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
100622520  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
100622559  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100623628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100623661  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100623707  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100624152  RASA4B; ras GTPase-activating protein 4B isoform X3 [KO:K17630]
100624229  RALB; ras-related protein Ral-B [KO:K07835]
100624533  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
100625381  RAB5B; ras-related protein Rab-5B [KO:K07888]
100626022  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100626093  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100626606  [KO:K10784]
100627019  ABL2; Abelson tyrosine-protein kinase 2 isoform X6 [KO:K08887] [EC:2.7.10.2]
100627123  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100627149  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100627579  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100627936  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100736832  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100737448  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100738064  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
100738118  CALML5; calmodulin-like protein 5 [KO:K02183]
100738968  NGF; beta-nerve growth factor [KO:K02582]
100739325  [KO:K07360] [EC:2.7.10.2]
100739349  NRAS; GTPase NRas precursor [KO:K07828]
100739510  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102162529  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102164918  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
102165618  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102166564  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102166994  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102167388  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
106504097  RASAL2; ras GTPase-activating protein nGAP isoform X4 [KO:K17633]
110255211  [KO:K04549]
110255290  [KO:K10784]
110255928  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110257615  [KO:K10785]
110259208  HRAS; GTPase HRas isoform X1 [KO:K02833]
110259297  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
110259378  FGF22; fibroblast growth factor 22 [KO:K04358]
110259382  SHC2; SHC-transforming protein 2 [KO:K17447]
110259864  [KO:K01047] [EC:3.1.1.4]
110261109  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110261346  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110261595  [KO:K10784]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
396717  FGF9; fibroblast growth factor 9 [KO:K04358]
396726  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
396729  TEK; angiopoietin-1 receptor isoform X6 [KO:K05121] [EC:2.7.10.1]
396730  ANGPT2; angiopoietin-2 precursor [KO:K05466]
396755  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
396762  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
396763  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
396810  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
396838  CALM3; calmodulin [KO:K02183]
396849  RHOA; transforming protein RhoA [KO:K04513]
396916  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
397009  ANGPT1; angiopoietin-1 precursor [KO:K05465]
397070  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
397083  EGF; pro-epidermal growth factor precursor [KO:K04357]
397157  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
397158  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
397184  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
397281  FGF7; fibroblast growth factor 7 [KO:K04358]
397311  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
397350  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
397415  INS; insulin precursor [KO:K04526]
397440  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
397484  TGFA; protransforming growth factor alpha precursor [KO:K08774]
397491  IGF1; insulin-like growth factor I precursor [KO:K05459]
397495  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
397497  FGF1; fibroblast growth factor 1 [KO:K18496]
397509  KITLG; kit ligand precursor [KO:K05461]
397536  BCL2L1; bcl-2-like protein 1 [KO:K04570]
397643  FGF2; fibroblast growth factor 2 [KO:K18497]
397652  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
414900  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
445013  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
445525  PLA2G1B; phospholipase A2, major isoenzyme precursor [KO:K01047] [EC:3.1.1.4]
654328  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
733705  FOXO4; forkhead box protein O4 [KO:K12358]
751869  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
780425  ARF6; ADP-ribosylation factor 6 [KO:K07941]
780428  CDC42; cell division control protein 42 homolog [KO:K04393]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
ssc04010  MAPK signaling pathway
ssc04015  Rap1 signaling pathway
ssc04020  Calcium signaling pathway
ssc04144  Endocytosis
ssc04151  PI3K-Akt signaling pathway
ssc04660  T cell receptor signaling pathway
ssc04720  Long-term potentiation
ssc04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

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