KEGG   PATHWAY: ssc05152
Entry
ssc05152                    Pathway                                
Name
Tuberculosis - Sus scrofa (pig)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ssc05152  Tuberculosis
ssc05152

Disease
H00342  Tuberculosis
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100037921  SLA-DQB1; SLA class II histocompatibility antigen, DQ haplotype C beta chain precursor [KO:K06752]
100037938  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
100038025  CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
100038328  [KO:K06856]
100049703  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100125346  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
100125540  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100125838  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
100126861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100126864  IFNGR2; interferon gamma receptor 2 precursor [KO:K05133]
100127166  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100127478  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100135040  SLA-DRA; MHC class II DR-alpha precursor [KO:K06752]
100135049  SLA-DOB; MHC class II, DO beta precursor [KO:K06752]
100135050  SLA-DMB; MHC class II, DM beta precursor [KO:K06752]
100135665  RELA; transcription factor p65 [KO:K04735]
100144483  NPG1; protegrin-1 precursor [KO:K13916]
100144499  RAB5A; ras-related protein Rab-5A [KO:K07887]
100151920  NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
100152100  IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414]
100152238  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
100152504  IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414]
100153090  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
100153325  [KO:K05414]
100153386  SLA-DRB1; MHC class II histocompatibility antigen SLA-DRB1 precursor [KO:K06752]
100153387  SLA-DQA1; SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor [KO:K06752]
100153403  EEA1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
100153661  [KO:K05414]
100153724  IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414]
100153830  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
100153927  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100154056  CALM1; calmodulin [KO:K02183]
100154503  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100154525  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
100154598  LAMP2; lysosome-associated membrane glycoprotein 2 isoform 1 precursor [KO:K06528]
100154896  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100154938  IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414]
100155546  IL23A; interleukin-23 subunit alpha precursor [KO:K05426]
100155648  RFXAP; LOW QUALITY PROTEIN: regulatory factor X-associated protein [KO:K08063]
100155841  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100156226  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100156561  IFN-ALPHA-10; interferon-alpha-10 precursor [KO:K05414]
100156630  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100156936  [KO:K05414]
100157352  IFN-ALPHA-1; interferon-alpha-1 precursor [KO:K05414]
100157587  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
100157735  IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414]
100157766  IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414]
100157996  SLA-DOA; SLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
100158082  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100170124  PMAP-36; antibacterial peptide PMAP-36 precursor [KO:K13916]
100170131  CYCS; cytochrome c [KO:K08738]
100170134  CD209; CD209 antigen [KO:K06563]
100303758  IFN-ALPHA-5; interferon, alpha 5 precursor [KO:K05414]
100310806  IFN-ALPHAOMEGA; interferon-alphaomega precursor [KO:K05414]
100511282  KSR1; kinase suppressor of Ras 1 isoform X3 [KO:K14958]
100513283  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100513811  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100514174  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
100516106  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
100516166  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100517711  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
100518835  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K08846] [EC:2.7.11.1]
100518913  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100518959  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100519210  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
100519295  [KO:K08738]
100519402  ATP6V0A4; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
100519528  CALML4; calmodulin-like 4 [KO:K02183]
100521065  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
100521183  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
100521494  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
100521769  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X3 [KO:K02154]
100522842  [KO:K08738]
100522926  CALM2; calmodulin [KO:K02183]
100523018  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
100523324  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X5 [KO:K07532]
100523862  RAB5C; ras-related protein Rab-5C [KO:K07889]
100525048  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
100525580  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
100525647  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
100525654  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
100620215  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100620340  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100621347  [KO:K08738]
100621483  CORO1A; coronin-1A [KO:K13882]
100622105  PLA2R1; LOW QUALITY PROTEIN: secretory phospholipase A2 receptor [KO:K06560]
100622795  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
100623585  CR1; LOW QUALITY PROTEIN: complement receptor type 1 [KO:K04011]
100623661  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100625117  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100625381  RAB5B; ras-related protein Rab-5B [KO:K07888]
100626014  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X7 [KO:K04515] [EC:2.7.11.17]
100627903  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100628226  RFXANK; DNA-binding protein RFXANK [KO:K08062]
100736562  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100737448  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100737904  [KO:K05414]
100738118  CALML5; calmodulin-like protein 5 [KO:K02183]
100738292  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
102159115  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102159373  [KO:K13916]
106504372  [KO:K06752]
106505672  IRAK2; interleukin-1 receptor-associated kinase-like 2 [KO:K04731] [EC:2.7.11.1]
110255221  [KO:K13916]
110256441  [KO:K13916]
110258075  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
110258648  [KO:K13916]
110258649  [KO:K13916]
110258650  [KO:K13916]
110258651  [KO:K13916]
110258711  [KO:K10059]
110259215  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
110260307  [KO:K06472]
110260605  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110260748  CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
110261242  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
396565  IL1B2; interleukin 1, beta [KO:K04519]
396603  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
396606  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
396607  TLR1; toll-like receptor 1 precursor [KO:K05398]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
396621  TLR6; toll-like receptor 6 [KO:K10169]
396623  TLR2; toll-like receptor 2 precursor [KO:K10159]
396628  VDR; vitamin D3 receptor [KO:K08539]
396629  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
396633  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
396646  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
396655  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
396657  IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135]
396660  CD74; CD74 antigen [KO:K06505]
396781  [KO:K06856]
396838  CALM3; calmodulin [KO:K02183]
396849  RHOA; transforming protein RhoA [KO:K04513]
396859  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
396943  ITGB2; integrin beta-2 precursor [KO:K06464]
396991  IFNG; interferon gamma precursor [KO:K04687]
397007  TLR9; toll-like receptor 9 precursor [KO:K10161]
397020  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
397053  IL12A; interleukin-12 subunit alpha [KO:K05406]
397055  CYP27B1; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
397057  IL18; interleukin-18 precursor [KO:K05482]
397072  C3; complement C3 precursor [KO:K03990]
397076  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
397078  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
397084  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
397086  TNF; tumor necrosis factor [KO:K03156]
397094  IL1A; interleukin-1 alpha precursor [KO:K04383]
397106  IL10; interleukin-10 precursor [KO:K05443]
397122  IL1B; interleukin-1 beta precursor [KO:K04519]
397201  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
397202  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
397241  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
397244  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
397250  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
397303  LBP; lipopolysaccharide-binding protein precursor [KO:K05399]
397360  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
397394  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
397400  TGFB3; transforming growth factor beta-3 precursor [KO:K13377]
397406  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983]
397459  ITGAM; integrin alpha-M isoform X2 [KO:K06461]
397472  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
397674  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
397684  FCGR3B; low affinity immunoglobulin gamma Fc region receptor III precursor [KO:K06463]
397686  IFNA1; interferon alpha-1 precursor [KO:K05414]
399500  IL6; interleukin-6 precursor [KO:K05405]
399541  TLR4; toll-like receptor 4 isoform 1 precursor [KO:K10160]
407610  PR39; antibacterial protein PR-39 precursor [KO:K13916]
445003  MRC1; macrophage mannose receptor 1 precursor [KO:K06560]
445013  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
445459  IFNB1; interferon beta precursor [KO:K05415]
445528  SLA-DMA; SLA-DM alpha chain precursor [KO:K06752]
492279  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
494565  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
494568  CTSD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
503700  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
574062  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
594852  BID; BH3-interacting domain death agonist [KO:K04726]
595105  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
595129  FADD; FAS-associated death domain protein [KO:K02373]
613130  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
613131  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b precursor [KO:K12560]
751869  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
ssc04010  MAPK signaling pathway
ssc04210  Apoptosis
ssc04612  Antigen processing and presentation
ssc04620  Toll-like receptor signaling pathway
ssc04621  NOD-like receptor signaling pathway
ssc04630  JAK-STAT signaling pathway
KO pathway
ko05152   

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