KEGG   PATHWAY: umr05167
Entry
umr05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Ursus maritimus (polar bear)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
umr05167  Kaposi sarcoma-associated herpesvirus infection
umr05167

Disease
H00041  Kaposi sarcoma
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656186  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103656206  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
103656234  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103656357  [KO:K06751]
103656694  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103656774  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103656833  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103657071  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103657107  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103657131  IRF3; interferon regulatory factor 3 [KO:K05411]
103657204  CALM3; calmodulin-3 [KO:K02183]
103657263  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
103657756  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103658473  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103658519  UBB; polyubiquitin-B isoform X1 [KO:K04551]
103658731  [KO:K04548]
103658734  [KO:K04546]
103658796  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103658871  IL6; interleukin-6 [KO:K05405]
103658902  [KO:K08738]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103659742  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
103659802  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103659933  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103660368  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103660496  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103660497  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103660510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103660550  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
103661026  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661697  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103661728  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103661850  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103661898  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103661934  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103662093  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103662147  [KO:K05414]
103662148  [KO:K05414]
103662149  [KO:K05414]
103662150  IFNB1; interferon beta [KO:K05415]
103662923  [KO:K08738]
103663028  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103663059  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103663109  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103663192  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103663212  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
103663361  [KO:K04545]
103663370  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103663663  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103663669  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
103663815  TCF7; transcription factor 7 isoform X1 [KO:K02620]
103664148  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103665275  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103665307  CXCL8; interleukin-8 [KO:K10030]
103665312  [KO:K05505]
103665390  [KO:K05505]
103665451  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103665481  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103665536  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103665538  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103665553  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103665687  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103666055  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103666628  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
103666643  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
103666660  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103666789  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103666985  [KO:K05414]
103667825  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103667893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103668461  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103668648  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103668810  [KO:K04498] [EC:2.3.1.48]
103668942  BECN2; beclin-2 [KO:K08334]
103669173  [KO:K02833]
103669180  CLEC2B; C-type lectin domain family 2 member B isoform X1 [KO:K10071]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103669422  NRAS; GTPase NRas [KO:K07828]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103669597  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103669754  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103669776  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103669832  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103669844  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
103669916  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
103670041  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103670304  CALM1; calmodulin-1 isoform X1 [KO:K02183]
103670505  CSF2; granulocyte-macrophage colony-stimulating factor isoform X1 [KO:K05427]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103670861  JUN; transcription factor AP-1 [KO:K04448]
103671004  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103671011  FOS; proto-oncogene c-Fos [KO:K04379]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103671072  FADD; FAS-associated death domain protein [KO:K02373]
103671092  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
103671139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103671240  CALM2; calmodulin-2 [KO:K02183]
103671271  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
103671340  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103671448  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
103671577  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103672268  [KO:K06751]
103672464  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
103672573  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
103672587  BECN1; beclin-1 isoform X2 [KO:K08334]
103672837  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103673110  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
103673131  RCAN1; calcipressin-1 isoform X2 [KO:K17901]
103673220  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
103673318  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103673673  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103673717  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103673943  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103674004  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103674115  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103674159  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103674340  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
103674455  E2F1; transcription factor E2F1 [KO:K17454]
103674591  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
103674633  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
103674885  CCR5; C-C chemokine receptor type 5 [KO:K04180]
103674890  [KO:K04178]
103674891  [KO:K04176]
103674933  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103675245  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103675694  BID; BH3-interacting domain death agonist [KO:K04726]
103676121  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103676238  [KO:K02183]
103676239  CALML3; calmodulin-like protein 3 [KO:K02183]
103676520  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103676755  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103676930  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103676947  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103677313  [KO:K21668]
103677317  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
103677360  [KO:K21668]
103677361  [KO:K21668]
103677438  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103677688  RB1; retinoblastoma-associated protein [KO:K06618]
103677943  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103677947  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103678196  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103678383  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
103678534  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103678657  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103678725  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
103678731  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103678768  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103679049  CALML4; calmodulin-like protein 4 isoform X3 [KO:K02183]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103679279  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
103679332  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103679584  RELA; transcription factor p65 [KO:K04735]
103679680  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103679990  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103680384  CTNNB1; catenin beta-1 [KO:K02105]
103680385  [KO:K05414]
103680386  [KO:K05414]
103680441  [KO:K06751]
103680537  CCR8; C-C chemokine receptor type 8 [KO:K04183]
103680561  [KO:K06751]
103680971  TLR3; toll-like receptor 3 [KO:K05401]
103680991  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103680999  CCR4; C-C chemokine receptor type 4 [KO:K04179]
103681653  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103681847  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103681871  C3; complement C3 [KO:K03990]
103681888  MAP2K7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103682041  CALML6; calmodulin-like protein 6 [KO:K02183]
103682042  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
103682158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
103682344  [KO:K06751]
121103043  [KO:K05414]
121104237  [KO:K08738]
121104340  [KO:K06751]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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Rev Med Virol 25:273-85 (2015)
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Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Purushothaman P, Uppal T, Verma SC
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Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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Related
pathway
umr04010  MAPK signaling pathway
umr04064  NF-kappa B signaling pathway
umr04110  Cell cycle
umr04115  p53 signaling pathway
umr04140  Autophagy - animal
umr04144  Endocytosis
umr04151  PI3K-Akt signaling pathway
umr04210  Apoptosis
umr04310  Wnt signaling pathway
umr04610  Complement and coagulation cascades
umr04620  Toll-like receptor signaling pathway
umr04630  JAK-STAT signaling pathway
umr04650  Natural killer cell mediated cytotoxicity
umr04668  TNF signaling pathway
KO pathway
ko05167   

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