KEGG   PATHWAY: mcal04014
Entry
mcal04014                   Pathway                                
Name
Ras signaling pathway - Mus caroli (Ryukyu mouse)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcal04014  Ras signaling pathway
mcal04014

Other DBs
GO: 0032318
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110291005  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110295684  Tgfa; protransforming growth factor alpha [KO:K08774]
110284837  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110291557  Fgf2; fibroblast growth factor 2 [KO:K18497]
110300580  Fgf20; fibroblast growth factor 20 [KO:K04358]
110295342  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110285629  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110287226  Fgf16; fibroblast growth factor 16 [KO:K04358]
110305760  Fgf18; fibroblast growth factor 18 [KO:K04358]
110308847  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110303818  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110309422  Fgf9; fibroblast growth factor 9 [KO:K04358]
110289950  Fgf7; fibroblast growth factor 7 [KO:K04358]
110296943  Fgf6; fibroblast growth factor 6 [KO:K04358]
110299316  Fgf4; fibroblast growth factor 4 [KO:K04358]
110299386  Fgf3; fibroblast growth factor 3 [KO:K04358]
110308330  Fgf10; fibroblast growth factor 10 [KO:K04358]
110299450  Fgf19; fibroblast growth factor 19 [KO:K22603]
110299358  Fgf21; fibroblast growth factor 21 [KO:K22429]
110297028  Fgf23; fibroblast growth factor 23 [KO:K22428]
110291584  Ngf; beta-nerve growth factor [KO:K02582]
110285237  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110296798  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
110299428  Ntf4; neurotrophin-4 [KO:K12457]
110299132  insulin-2 [KO:K04526]
110286053  insulin-1 [KO:K04526]
110304009  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110298427  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110294651  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110310626  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110290924  Pdgfc; platelet-derived growth factor C [KO:K05450]
110301590  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
110291496  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110302981  Kitlg; kit ligand isoform X1 [KO:K05461]
110297597  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110284402  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110285510  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110307029  Pgf; placenta growth factor [KO:K16859]
110287326  Vegfd; vascular endothelial growth factor D [KO:K05449]
110300171  Vegfc; vascular endothelial growth factor C [KO:K05449]
110294216  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110310421  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
110300338  Angpt2; angiopoietin-2 [KO:K05466]
110290227  Angpt4; angiopoietin-4 [KO:K05467]
110303946  Efna2; ephrin-A2 [KO:K05462]
110291707  Efna1; ephrin-A1 [KO:K05462]
110283991  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110291641  Efna3; ephrin-A3 isoform X1 [KO:K05462]
110291542  Efna4; ephrin-A4 isoform X2 [KO:K05462]
110304228  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110299550  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110299396  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110293909  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
110307648  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110305182  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110290875  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110307883  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110300622  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110297825  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
110295292  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110284880  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
110285184  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110294693  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110294537  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110294038  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110304471  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110294607  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110295947  Met; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
110293136  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110292090  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
110304772  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110300068  Gab1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
110298776  Gab2; GRB2-associated-binding protein 2 [KO:K08091]
110290710  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110303444  Shc2; SHC-transforming protein 2 [KO:K17447]
110308134  Shc3; SHC-transforming protein 3 [KO:K17448]
110289726  Shc4; SHC-transforming protein 4 [KO:K17449]
110294055  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
110306968  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110312423  Sos1; son of sevenless homolog 1 [KO:K03099]
110290454  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
110300336  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
110311236  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
110285321  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
110312642  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
110298815  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
110297598  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
110298793  Lat; linker for activation of T-cells family member 1 [KO:K07362]
110285717  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
110292306  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110294718  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110295995  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110290992  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
110301552  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110309306  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
110285794  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110308267  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110291468  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110303682  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110299246  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110292758  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110296688  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110300627  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110296551  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110283696  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110296864  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
110305185  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110308129  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
110285719  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110311574  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110296148  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110286675  calmodulin-alpha-like [KO:K02183]
110308577  Calml3; calmodulin-like protein 3 [KO:K02183]
110308601  calmodulin-4 [KO:K02183]
110286582  calmodulin [KO:K02183]
110306434  Calm1; calmodulin-1 [KO:K02183]
110302040  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
110297869  Calm3; calmodulin-3 [KO:K02183]
110294847  calmodulin-like [KO:K02183]
110312637  Calm2; calmodulin-2 [KO:K02183]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110300983  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
110298333  Rras; ras-related protein R-Ras [KO:K07829]
110297889  Rras2; ras-related protein R-Ras2 [KO:K07830]
110304532  Nf1; neurofibromin isoform X1 [KO:K08052]
110308133  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
110301714  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
110300114  Rasa3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
110294964  Rasa4b; ras GTPase-activating protein 4B [KO:K17630]
110283964  Syngap1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
110294489  Rasal1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
110299958  Rasal2; ras GTPase-activating protein nGAP isoform X4 [KO:K17633]
110312703  Rasal3; RAS protein activator like-3 isoform X1 [KO:K17634]
110301468  Rassf1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
110293075  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
110284093  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
110311394  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110310226  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110305163  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110298300  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110311434  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110286479  Pak3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
110297818  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110289454  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110288173  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110292411  transforming protein RhoA [KO:K04513]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110287188  Ikbkg; NF-kappa-B essential modulator isoform X4 [KO:K07210]
110285285  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110300158  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110291231  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110285703  Rela; transcription factor p65 [KO:K04735]
110285481  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110288823  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
110286655  Foxo4; forkhead box protein O4 [KO:K12358]
110300709  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110307135  Ralgapa1; ral GTPase-activating protein subunit alpha-1 isoform X2 [KO:K25768]
110288765  Ralgapa2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
110309878  Ralgapb; ral GTPase-activating protein subunit beta isoform X7 [KO:K25769]
110286147  Ralgds; ral guanine nucleotide dissociation stimulator isoform X6 [KO:K08732]
110304692  Rgl1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
110283844  Rgl2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
110308275  Rala; ras-related protein Ral-A [KO:K07834]
110291027  Ralb; ras-related protein Ral-B [KO:K07835]
110304819  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
110290757  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
110307923  Exoc2; exocyst complex component 2 [KO:K17637]
110303265  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110305497  Rel; proto-oncogene c-Rel [KO:K09254]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110283823  Ralbp1; ralA-binding protein 1 [KO:K08773]
110292517  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110284326  Afdn; afadin isoform X17 [KO:K05702]
110285474  Shoc2; leucine-rich repeat protein SHOC-2 [KO:K19613]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110311435  Pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
110293160  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110292815  Pla2g5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110292816  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
110303363  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
110295155  Pla2g1b; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110311666  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110306129  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110291110  Pla2g12a; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110293697  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110293705  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110293232  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110289370  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110284581  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
110289583  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110294088  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
110298861  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
110290316  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
110310640  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110285658  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
110286681  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110301829  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
110311296  Ets2; protein C-ets-2 [KO:K21932]
110294355  Brap; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
110305327  Ksr1; kinase suppressor of Ras 1 isoform X4 [KO:K14958]
110294533  Ksr2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
110307233  Rapgef5; rap guanine nucleotide exchange factor 5 [KO:K08019]
110290796  Rap1a; ras-related protein Rap-1A [KO:K04353]
110303320  Rap1b; ras-related protein Rap-1b [KO:K07836]
110285551  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [KO:K05860] [EC:3.1.4.11]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110289525  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
110292303  Abl2; tyrosine-protein kinase ABL2 isoform X3 [KO:K08887] [EC:2.7.10.2]
110312675  Rab5a; ras-related protein Rab-5A [KO:K07887]
110291569  ras-related protein Rab-5B [KO:K07888]
110303170  Rab5b; ras-related protein Rab-5B [KO:K07888]
110305560  Rab5c; ras-related protein Rab-5C [KO:K07889]
110307102  Arf6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mcal04010  MAPK signaling pathway
mcal04015  Rap1 signaling pathway
mcal04020  Calcium signaling pathway
mcal04144  Endocytosis
mcal04151  PI3K-Akt signaling pathway
mcal04660  T cell receptor signaling pathway
mcal04720  Long-term potentiation
mcal04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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