KEGG   PATHWAY: pon05161
Entry
pon05161                    Pathway                                
Name
Hepatitis B - Pongo abelii (Sumatran orangutan)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pon05161  Hepatitis B
pon05161

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100446648  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100458112  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
100459982  TGFB1; transforming growth factor beta-1 [KO:K13375]
100461291  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
100433208  TGFB3; transforming growth factor beta-3 [KO:K13377]
100450864  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100459236  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100448249  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100174482  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100459133  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100437424  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100450873  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
100459286  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
100455260  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100445634  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100461418  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100173610  DDB1; DNA damage-binding protein 1 [KO:K10610]
100454099  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100453309  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100173609  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100137177  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100171925  YWHAQ; 14-3-3 protein theta [KO:K16197]
100439299  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100174735  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100440586  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100449496  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
100459445  NF-kappa-B inhibitor alpha [KO:K04734]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100456049  RELA; transcription factor p65 [KO:K04735]
100455867  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100938429  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100454097  BAD; bcl2-associated agonist of cell death [KO:K02158]
100439256  FADD; FAS-associated death domain protein [KO:K02373]
100172115  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100174433  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100173269  BID; BH3-interacting domain death agonist [KO:K04726]
100450682  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100459074  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100171479  CYCS; cytochrome c [KO:K08738]
100462404  cytochrome c-like [KO:K08738]
112128551  cytochrome c-like [KO:K08738]
100445149  cytochrome c-like [KO:K08738]
112128607  cytochrome c-like [KO:K08738]
112130824  cytochrome c-like [KO:K08738]
112132396  LOW QUALITY PROTEIN: cytochrome c 2-like [KO:K08738]
112133797  cytochrome c-like [KO:K08738]
112134675  cytochrome c-like [KO:K08738]
112134685  cytochrome c-like [KO:K08738]
112134371  cytochrome c-like [KO:K08738]
112134960  cytochrome c-like [KO:K08738]
112135506  cytochrome c-like [KO:K08738]
100460459  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100435491  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100938140  LOW QUALITY PROTEIN: inactive caspase-12 [KO:K04741] [EC:3.4.22.-]
100436165  caspase-12 isoform X2 [KO:K04741] [EC:3.4.22.-]
100172652  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100435218  TP53; cellular tumor antigen p53 [KO:K04451]
100449200  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100453784  CCNA2; cyclin-A2 [KO:K06627]
100446748  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100438282  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100461587  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100462155  RB1; retinoblastoma-associated protein [KO:K06618]
100435851  E2F1; transcription factor E2F1 [KO:K17454]
100458002  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100448297  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
100173990  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100451563  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100436209  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100450332  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100458008  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
100461543  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100447558  TNF; tumor necrosis factor [KO:K03156]
100433477  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100172517  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100433988  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100439493  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100171541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100173683  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100452011  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100436344  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100461695  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100462537  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100173709  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100174591  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100174613  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
100436498  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100450292  JUN; transcription factor AP-1 [KO:K04448]
100439171  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100450554  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100294619  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100432292  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100436186  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100438869  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100127093  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100441756  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100462459  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100431578  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100439720  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100172895  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
100437111  interleukin-8 isoform X1 [KO:K10030]
100437488  LOW QUALITY PROTEIN: interleukin-8 [KO:K10030]
112128505  interleukin-8 [KO:K10030]
100457788  PCNA; proliferating cell nuclear antigen [KO:K04802]
100431871  ARAF; serine/threonine-protein kinase A-Raf isoform X4 [KO:K08845] [EC:2.7.11.1]
100442288  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100462290  FOS; proto-oncogene c-Fos [KO:K04379]
100432611  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100456464  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
100460593  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100440980  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
100457237  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100447243  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100437883  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
100449432  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103888975  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100174071  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100171454  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100453941  IL6; interleukin-6 isoform X2 [KO:K05405]
100457536  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
100448382  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100449269  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100449853  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100437263  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100438358  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100431600  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
100439696  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
100442382  TLR3; toll-like receptor 3 [KO:K05401]
100455734  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100443290  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
100438807  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100432985  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100460079  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100448480  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100433568  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100446823  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
100441280  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
100460542  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
100459543  interferon alpha-10 [KO:K05414]
100432532  IFNA8; interferon alpha-8 [KO:K05414]
100432906  IFNA2; interferon alpha-2 [KO:K05414]
100434036  IFNA6; interferon alpha-6 [KO:K05414]
100434796  interferon alpha-5 [KO:K05414]
100435169  interferon alpha-14 [KO:K05414]
100438871  interferon alpha-17-like [KO:K05414]
100439978  IFNA21; interferon alpha-21 [KO:K05414]
100432153  interferon alpha-1/13 [KO:K05414]
100445711  interferon alpha-10-like [KO:K05414]
100438149  interferon alpha-4-like [KO:K05414]
100437034  interferon alpha-4-like [KO:K05414]
100433301  interferon alpha-1/13-like [KO:K05414]
112134962  interferon alpha-10-like [KO:K05414]
100443523  interferon alpha-4-like [KO:K05414]
100441074  IFNB1; interferon beta [KO:K05415]
100443118  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
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Related
pathway
pon04010  MAPK signaling pathway
pon04064  NF-kappa B signaling pathway
pon04110  Cell cycle
pon04115  p53 signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04620  Toll-like receptor signaling pathway
pon04622  RIG-I-like receptor signaling pathway
pon04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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