KEGG   PATHWAY: aml05165
Entry
aml05165                    Pathway                                
Name
Human papillomavirus infection - Ailuropoda melanoleuca (giant panda)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
aml05165  Human papillomavirus infection
aml05165

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100463538  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
100463698  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100463778  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100463860  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
100463875  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100463941  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
100464071  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100464079  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
100464134  FN1; fibronectin isoform X1 [KO:K05717]
100464171  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100464196  NRAS; GTPase NRas [KO:K07828]
100464293  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100464522  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
100464621  FZD6; frizzled-6 isoform X1 [KO:K02376]
100464651  ATP6V0D1; LOW QUALITY PROTEIN: V-type proton ATPase subunit d 1 [KO:K02146]
100464670  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100464781  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
100464897  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100464998  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100465076  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100465112  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100465171  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
100465448  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100465524  [KO:K06751]
100465530  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
100465597  LAMB3; laminin subunit beta-3 isoform X2 [KO:K06244]
100465654  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100465690  TSC2; tuberin isoform X1 [KO:K07207]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100465724  THBS1; thrombospondin-1 [KO:K16857]
100465768  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465830  LAMA1; laminin subunit alpha-1 [KO:K05637]
100465872  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152]
100465950  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100465977  RHEB; GTP-binding protein Rheb [KO:K07208]
100466047  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
100466067  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100466255  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
100466374  [KO:K06751]
100466406  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100466672  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
100466685  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
100467477  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100467643  [KO:K01357]
100467719  TCF7L2; transcription factor 7-like 2 isoform X6 [KO:K04491]
100467733  [KO:K04357]
100467779  FZD8; frizzled-8 [KO:K02375]
100467824  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100467896  WNT6; protein Wnt-6 [KO:K00445]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100467928  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100468021  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100468149  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100468235  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100468314  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100468422  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100468425  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100468561  WNT11; protein Wnt-11 [KO:K01384]
100468584  WNT4; protein Wnt-4 [KO:K00408]
100468694  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100468710  VWF; von Willebrand factor [KO:K03900]
100468722  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100468810  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
100468831  FZD3; frizzled-3 isoform X1 [KO:K02329]
100468841  TNR; tenascin-R isoform X1 [KO:K06252]
100468855  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
100468916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100468934  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100469151  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100469196  FZD1; frizzled-1 [KO:K02432]
100469216  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100469231  [KO:K04632]
100469249  FZD2; frizzled-2 [KO:K02235]
100469264  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100469387  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100469483  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100469745  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100469757  MAML1; mastermind-like protein 1 [KO:K06061]
100469765  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
100469787  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
100469813  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100469928  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100470083  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100470247  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
100470379  FZD4; frizzled-4 [KO:K02354]
100470452  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100470568  AIME-128; DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
100470647  HES4; LOW QUALITY PROTEIN: transcription factor HES-4 [KO:K09089]
100470696  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
100470778  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100470793  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100470867  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100470963  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100471009  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100471122  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100471182  FOXO1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
100471184  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100471385  TADA3; transcriptional adapter 3 [KO:K11315]
100471517  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100471530  TSC1; hamartin isoform X1 [KO:K07206]
100471555  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100471563  TNF; tumor necrosis factor [KO:K03156]
100471588  THBS4; thrombospondin-4 [KO:K04659]
100471672  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100471721  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
100471884  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100471963  TNN; tenascin-N [KO:K06252]
100471972  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100472005  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100472104  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100472117  TUBG1; tubulin gamma-1 chain [KO:K10389]
100472167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100472241  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100472257  APC; adenomatous polyposis coli protein isoform X5 [KO:K02085]
100472276  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
100472358  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100472368  [KO:K10389]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100472419  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100472460  WNT9B; protein Wnt-9b [KO:K01064]
100472488  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100472572  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100472613  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100473018  AXIN1; axin-1 isoform X1 [KO:K02157]
100473021  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100473035  HES2; transcription factor HES-2 [KO:K09087]
100473350  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
100473460  JAK1; tyrosine-protein kinase JAK1 isoform X2 [KO:K11217] [EC:2.7.10.2]
100473522  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100473550  HES3; transcription factor HES-3 [KO:K09088]
100473652  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
100473680  [KO:K04632]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100473835  WNT3A; protein Wnt-3a [KO:K00312]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100473854  WNT5B; protein Wnt-5b isoform X3 [KO:K00444]
100473914  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100473937  BAD; bcl2-associated agonist of cell death [KO:K02158]
100474026  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100474031  JAG1; protein jagged-1 [KO:K06052]
100474079  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100474212  ITGB7; integrin beta-7 [KO:K06590]
100474261  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100474366  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100474396  SOS2; son of sevenless homolog 2 isoform X9 [KO:K03099]
100474494  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
100474505  PXN; paxillin isoform X4 [KO:K05760]
100474554  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
100474711  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100474885  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100474982  WNT7B; protein Wnt-7b [KO:K00572]
100474986  CHAD; chondroadherin [KO:K06248]
100475007  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100475062  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X2 [KO:K13365]
100475077  LAMC2; laminin subunit gamma-2 [KO:K06246]
100475103  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
100475107  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
100475153  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
100475180  CCNA1; cyclin-A1 [KO:K06627]
100475211  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100475265  WNT10B; protein Wnt-10b isoform X1 [KO:K01357]
100475280  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100475480  IRF9; interferon regulatory factor 9 [KO:K04693]
100475539  SPP1; osteopontin isoform X2 [KO:K06250]
100475572  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
100475917  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100476112  IBSP; bone sialoprotein 2 [KO:K06253]
100476147  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
100476237  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100476256  ITGB3; integrin beta-3 [KO:K06493]
100476326  LAMC1; laminin subunit gamma-1 [KO:K05635]
100476382  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100476389  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100476403  ITGA2; integrin alpha-2 [KO:K06481]
100476528  TCF7; transcription factor 7 isoform X2 [KO:K02620]
100476556  IFNB1; interferon beta [KO:K05415]
100476665  NFX1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
100476691  AIME-152; class I histocompatibility antigen, Aime-152 precursor [KO:K06751]
100476784  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100476812  [KO:K05414]
100476899  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100477069  AXIN2; axin-2 isoform X1 [KO:K04385]
100477088  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
100477095  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
100477198  LAMC3; laminin subunit gamma-3 [KO:K06247]
100477312  [KO:K05414]
100477345  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
100477380  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100477559  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
100477562  [KO:K05414]
100477609  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
100477711  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100477714  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100477725  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
100477761  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
100477834  CTNNB1; catenin beta-1 [KO:K02105]
100477838  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100477956  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
100477974  LAMB2; laminin subunit beta-2 [KO:K06243]
100478019  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100478068  [KO:K05414]
100478108  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
100478235  CHD4; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
100478297  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100478321  [KO:K05414]
100478371  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100478424  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100478512  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100478649  FZD5; frizzled-5 [KO:K02375]
100478660  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100478681  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7 [KO:K04354]
100478752  COL4A1; collagen alpha-1(IV) chain isoform X4 [KO:K06237]
100478914  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100479004  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100479208  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100479237  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479342  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
100479433  ITGA5; integrin alpha-5 [KO:K06484]
100479467  CCND3; G1/S-specific cyclin-D3 isoform X4 [KO:K10152]
100479481  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100479688  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100479748  ITGA3; integrin alpha-3 [KO:K06482]
100479765  FZD10; frizzled-10 [KO:K02842]
100479895  COMP; cartilage oligomeric matrix protein [KO:K04659]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100480005  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100480008  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100480070  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100480195  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100480237  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
100480310  ITGA9; integrin alpha-9 [KO:K06585]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100480458  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100480511  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
100480638  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100480690  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100480865  PATJ; inaD-like protein isoform X1 [KO:K06092]
100480900  VTN; vitronectin [KO:K06251]
100480910  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X10 [KO:K04354]
100481026  THBS2; thrombospondin-2 isoform X2 [KO:K04659]
100481236  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100481439  HES1; transcription factor HES-1 [KO:K06054]
100481469  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100481489  DLG1; disks large homolog 1 isoform X7 [KO:K12076]
100481615  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100481665  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
100481684  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
100481821  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100481921  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100481969  IRF1; interferon regulatory factor 1 [KO:K09444]
100482129  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100482271  CCNA2; cyclin-A2 [KO:K06627]
100482486  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X5 [KO:K10691] [EC:2.3.2.27]
100482526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100482604  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100482679  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
100482697  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100482780  LAMA5; laminin subunit alpha-5 [KO:K06240]
100482823  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100482953  TBP; TATA-box-binding protein [KO:K03120]
100482982  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
100482983  VEGFA; vascular endothelial growth factor A [KO:K05448]
100483224  [KO:K14608]
100483347  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100483435  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100483471  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
100483482  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100483583  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
100483589  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100483627  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100483894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100483904  AIME-1906; class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100483953  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100484068  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100484104  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100484185  ITGA2B; integrin alpha-IIb [KO:K06476]
100484531  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100484669  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
100484712  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100484786  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100484892  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
100484923  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105234532  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
105236208  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
105237456  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
105238191  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105238487  HES7; transcription factor HES-7 [KO:K09087]
105240457  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105240522  COL9A1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
105241345  [KO:K06238]
105241360  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
105241843  [KO:K06751]
105242046  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
105242265  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
109488766  [KO:K06751]
109489608  FZD7; frizzled-7 [KO:K02432]
117795005  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
117795031  WNT10A; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
117795744  E2F1; transcription factor E2F1 [KO:K17454]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
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J Virol 87:6062-72 (2013)
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Related
pathway
aml04064  NF-kappa B signaling pathway
aml04110  Cell cycle
aml04115  p53 signaling pathway
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04310  Wnt signaling pathway
aml04330  Notch signaling pathway
aml04510  Focal adhesion
aml04520  Adherens junction
aml04530  Tight junction
aml04612  Antigen processing and presentation
aml04620  Toll-like receptor signaling pathway
aml04630  JAK-STAT signaling pathway
KO pathway
ko05165   

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