KEGG   PATHWAY: ccan04621
Entry
ccan04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Castor canadensis (American beaver)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
ccan04621  NOD-like receptor signaling pathway
ccan04621

Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109681245  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
109700547  Nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
109690126  Ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
109691919  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109681514  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109696400  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109695843  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
109697260  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109701168  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
109699439  Il18; interleukin-18 isoform X1 [KO:K05482]
109679557  Il6; interleukin-6 [KO:K05405]
109690391  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
109691927  Cxcl8; interleukin-8 [KO:K10030]
109700067  growth-regulated protein homolog gamma-like [KO:K05505]
109691926  growth-regulated protein homolog gamma-like [KO:K05505]
109674458  C-C motif chemokine 2-like [KO:K14624]
109674461  eotaxin-like [KO:K14624]
109693487  Ccl5; C-C motif chemokine 5 [KO:K12499]
109699008  Camp; cathelicidin antimicrobial peptide [KO:K13916]
109674521  defensin-5-like [KO:K05230]
109678543  defensin-5-like [KO:K05230]
109678544  defensin-5-like [KO:K05230]
109678545  neutrophil antibiotic peptide NP-1-like [KO:K05230]
109702618  neutrophil defensin 4-like [KO:K05230]
109674519  beta-defensin 103-like [KO:K23126]
109701706  Nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
109698497  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109692995  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109692528  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109700187  Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
109683259  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109684381  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109703004  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
109697389  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109689865  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109689849  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109697648  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109700777  Jun; transcription factor AP-1 [KO:K04448]
109695961  Atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
109701355  Atg5; autophagy protein 5 isoform X1 [KO:K08339]
109691512  Atg12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
109674552  Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
109684019  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
109689711  Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
109696466  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
109685898  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109687152  Sugt1; protein SGT1 homolog [KO:K12795]
109690793  sharpin [KO:K20894]
109687017  Rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
109685866  Rnf31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
109700263  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
109695665  Card6; caspase recruitment domain-containing protein 6 isoform X1 [KO:K12797]
109698108  Trip6; thyroid receptor-interacting protein 6 [KO:K12792]
109687833  Erbin; erbin isoform X1 [KO:K12796]
109689097  Birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
109689098  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
109699331  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109692314  Traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
109693564  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109699034  Card9; caspase recruitment domain-containing protein 9 [KO:K12794]
109697032  Tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
109691285  Mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
109688807  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109698137  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109697216  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
109692593  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
109683903  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
109698071  Irf7; interferon regulatory factor 7 [KO:K09447]
109690928  interferon alpha-21-like [KO:K05414]
109702568  interferon alpha-2-like [KO:K05414]
109688729  interferon alpha-21-like [KO:K05414]
109688957  interferon alpha-21-like [KO:K05414]
109689103  interferon alpha-4-like [KO:K05414]
109689580  interferon alpha-1/13-like [KO:K05414]
109689888  interferon alpha-17-like [KO:K05414]
109689666  interferon alpha-1/13-like [KO:K05414]
109690286  interferon alpha-10-like [KO:K05414]
109689981  interferon alpha-4-like [KO:K05414]
109690431  interferon alpha-10-like [KO:K05414]
109696215  Nlrx1; NLR family member X1 [KO:K12653]
109695094  Antxr1; anthrax toxin receptor 1 [KO:K20909]
109700410  Antxr2; anthrax toxin receptor 2 [KO:K20909]
109684890  NACHT, LRR and PYD domains-containing protein 1a-like isoform X1 [KO:K12798]
109684893  NACHT, LRR and PYD domains-containing protein 1a-like [KO:K12798]
109682713  Pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
109694935  Casp1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
109693757  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
109691766  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
109682023  Ctsb; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
109687959  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
109678254  LOW QUALITY PROTEIN: pannexin-1-like [KO:K03443]
109679346  P2rx7; P2X purinoceptor 7 [KO:K05220]
109701526  P2X purinoceptor 7-like [KO:K05220]
109689139  Trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
109699886  Trpm7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
109692413  Trpv2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
109674535  Gprc6a; LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A [KO:K04622]
109683285  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109684223  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
109701244  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109699340  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109674831  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
109687056  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
109686691  Itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109697584  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
109693642  Vdac2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
109700211  voltage-dependent anion-selective channel protein 2 [KO:K15040]
109696398  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
109688244  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
109675879  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
109675880  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
109681969  2'-5'-oligoadenylate synthase 3-like isoform X1 [KO:K14216] [EC:2.7.7.84]
109681970  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
109679313  Rnasel; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165]
109689407  Dhx33; putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
109689665  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
109683965  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
109695449  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
109685840  Ripk3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
109689200  dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
109689202  Dnm1l; dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
109701057  Nampt; nicotinamide phosphoribosyltransferase isoform X1 [KO:K03462] [EC:2.4.2.12]
109698413  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
109692739  cytochrome b-245 light chain [KO:K08009]
109694614  Txnip; thioredoxin-interacting protein [KO:K20910]
109692935  Txn; thioredoxin [KO:K03671]
109685196  Txn2; thioredoxin, mitochondrial [KO:K03671]
109698983  Nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
109702867  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
109682122  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109696011  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
109690412  Gpsm3; G-protein-signaling modulator 3 [KO:K15838]
109680953  LOW QUALITY PROTEIN: immunity-related GTPase family M protein-like [KO:K14139] [EC:3.6.5.-]
109690272  LOW QUALITY PROTEIN: immunity-related GTPase family M protein 1-like [KO:K14139] [EC:3.6.5.-]
109692234  immunity-related GTPase family M protein-like isoform X1 [KO:K14139] [EC:3.6.5.-]
109682741  Pydc1; pyrin domain-containing protein 1 [KO:K12802]
109682401  pyrin domain-containing protein 1-like [KO:K12802]
109700602  Mefv; pyrin [KO:K12803]
109697411  Pstpip1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
109689613  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109700274  Fadd; FAS-associated death domain protein [KO:K02373]
109698996  Nlrp6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
109685349  NACHT, LRR and PYD domains-containing protein 7-like [KO:K20864]
109693150  Nlrp12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
109688592  Naip; baculoviral IAP repeat-containing protein 1 [KO:K12807]
109699038  Nlrc4; NLR family CARD domain-containing protein 4 [KO:K12805]
109693718  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
109674581  LOW QUALITY PROTEIN: guanylate-binding protein 5-like [KO:K20898]
109697948  interferon-activable protein 203-like isoform X1 [KO:K20914]
109696048  Tp53bp1; tumor suppressor p53-binding protein 1 isoform X1 [KO:K20915]
109697844  Rhoa; transforming protein RhoA [KO:K04513]
109690388  transforming protein RhoA-like isoform X1 [KO:K04513]
109687611  Pkn1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
109682116  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
109682601  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
109680087  LOW QUALITY PROTEIN: guanylate-binding protein 4-like [KO:K20899]
109698697  Gbp1; guanylate-binding protein 1 [KO:K20899]
109680751  guanylate-binding protein 4-like [KO:K20899]
109694936  caspase-4-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
109690826  Gsdmd; LOW QUALITY PROTEIN: gasdermin-D [KO:K20917]
109686809  interferon alpha/beta receptor 1-like [KO:K05130]
109699947  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109699504  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
109693177  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
109679865  LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
109682738  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109686120  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
109685847  Irf9; interferon regulatory factor 9 [KO:K04693]
109700701  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
109687793  Ticam1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
109684529  Myd88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
109684435  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109689178  Tmem173; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
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pathway
ccan04010  MAPK signaling pathway
ccan04064  NF-kappa B signaling pathway
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ccan04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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