KEGG   PATHWAY: ggo04014
Entry
ggo04014                    Pathway                                
Name
Ras signaling pathway - Gorilla gorilla gorilla (western lowland gorilla)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
ggo04014  Ras signaling pathway
ggo04014

Other DBs
GO: 0032318
Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101153700  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
101140326  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101137337  FGF2; fibroblast growth factor 2 [KO:K18497]
101142002  FGF18; fibroblast growth factor 18 [KO:K04358]
101140831  FGF6; fibroblast growth factor 6 [KO:K04358]
101128423  FGF9; fibroblast growth factor 9 [KO:K04358]
101137223  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101146312  FGF16; fibroblast growth factor 16 [KO:K04358]
101143620  FGF20; fibroblast growth factor 20 [KO:K04358]
101131137  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101135749  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101135528  FGF10; fibroblast growth factor 10 [KO:K04358]
101129138  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101132851  FGF4; fibroblast growth factor 4 [KO:K04358]
101133590  FGF3; fibroblast growth factor 3 [KO:K04358]
101126805  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129526430  fibroblast growth factor 7-like [KO:K04358]
101149990  FGF21; fibroblast growth factor 21 [KO:K22429]
101140441  FGF23; fibroblast growth factor 23 [KO:K22428]
101149785  NGF; beta-nerve growth factor isoform X3 [KO:K02582]
101134399  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101153606  NTF4; neurotrophin-4 [KO:K12457]
101154397  IGF1; insulin-like growth factor I isoform X4 [KO:K05459]
101132059  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101138492  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101144807  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101134877  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101125404  KITLG; kit ligand isoform X1 [KO:K05461]
101131949  VEGFA; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
101128291  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101125053  PGF; placenta growth factor isoform X1 [KO:K16859]
101140874  VEGFC; vascular endothelial growth factor C [KO:K05449]
101140168  VEGFD; vascular endothelial growth factor D [KO:K05449]
101127877  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101145716  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101147615  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
101153008  ANGPT4; angiopoietin-4 [KO:K05467]
101129420  EFNA2; ephrin-A2 [KO:K05462]
101124086  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101146217  EFNA3; ephrin-A3 isoform X2 [KO:K05462]
115930092  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101126190  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101152179  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101153046  FGFR2; fibroblast growth factor receptor 2 isoform X5 [KO:K05093] [EC:2.7.10.1]
101139997  FGFR3; fibroblast growth factor receptor 3 isoform X11 [KO:K05094] [EC:2.7.10.1]
101145205  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101139048  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101125993  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
101140182  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101154546  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101124928  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101150577  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101151662  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101126389  KIT; mast/stem cell growth factor receptor Kit isoform X7 [KO:K05091] [EC:2.7.10.1]
101131781  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101130379  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
101127110  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101127399  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
101153987  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101141926  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101133976  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101147447  GAB1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
101148004  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
101136424  SHC1; SHC-transforming protein 1 isoform X4 [KO:K06279]
101129046  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
101127418  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
101154420  SHC4; SHC-transforming protein 4 [KO:K17449]
101133729  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
101130824  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101137539  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
101135199  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101133643  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101132761  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101125864  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
101147649  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101139136  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
101138805  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
101137404  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
101154353  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101134530  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
101146603  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101145049  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
109025414  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
101153772  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101141949  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101138742  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 isoform X2 [KO:K04542]
109027862  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115936218  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101140639  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109023336  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101148095  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
109028453  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
101139938  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101147632  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X2 [KO:K04347]
101139427  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101133147  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101139212  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101134560  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101151469  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101134260  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101145782  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101125808  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X3 [KO:K12326]
101146203  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X9 [KO:K05208]
101124569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101127573  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101151475  CALML3; calmodulin-like protein 3 [KO:K02183]
101151113  CALML5; calmodulin-like protein 5 [KO:K02183]
101139397  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101140627  calmodulin-2-like [KO:K02183]
101136425  HRAS; GTPase HRas isoform X1 [KO:K02833]
101144039  KRAS; GTPase KRas isoform X2 [KO:K07827]
101146562  NRAS; GTPase NRas [KO:K07828]
101146138  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
109024246  RRAS; ras-related protein R-Ras [KO:K07829]
101135999  RASA1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
101136814  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
115935415  ras GTPase-activating protein 4-like [KO:K17630]
101133419  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
101129623  RASAL1; rasGAP-activating-like protein 1 isoform X6 [KO:K17632]
101128532  RASAL2; ras GTPase-activating protein nGAP isoform X4 [KO:K17633]
101150826  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
101124427  RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
101128172  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
101129803  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101125464  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101141534  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101138276  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101130725  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101141425  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
101127864  PAK4; serine/threonine-protein kinase PAK 4 isoform X2 [KO:K05734] [EC:2.7.11.1]
101124352  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101140999  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101134778  RHOA; transforming protein RhoA [KO:K04513]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101145841  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115932121  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
101137405  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101141659  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101153465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101150285  RELA; transcription factor p65 isoform X1 [KO:K04735]
101151128  BAD; bcl2-associated agonist of cell death [KO:K02158]
101142025  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101137781  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101135906  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
101126769  RALGAPB; ral GTPase-activating protein subunit beta isoform X2 [KO:K25769]
101144743  RALGDS; ral guanine nucleotide dissociation stimulator isoform X3 [KO:K08732]
101134982  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X2 [KO:K17635]
101146057  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
101149508  RALA; ras-related protein Ral-A [KO:K07834]
101135135  ras-related protein Ral-A-like [KO:K07834]
101132362  RALB; ras-related protein Ral-B isoform X2 [KO:K07835]
101135150  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101135996  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101148892  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
101138038  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101152096  REL; proto-oncogene C-Rel isoform X1 [KO:K09254]
101152026  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101124033  MAPK8; mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101133141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101149028  RALBP1; RalA-binding protein 1 [KO:K08773]
101124029  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101145438  AFDN; afadin isoform X17 [KO:K05702]
101137044  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
101136454  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101132391  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101126885  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101150916  PLA1A; phospholipase A1 member A isoform X2 [KO:K13618] [EC:3.1.1.111]
101149596  PLA2G12A; group XIIA secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
101131065  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101128257  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101127421  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101152432  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
101153162  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101151003  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101153531  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101151354  PLA2G2A; phospholipase A2, membrane associated isoform X1 [KO:K01047] [EC:3.1.1.4]
101151897  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101125614  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
129527628  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
109025233  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101137812  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101138793  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101147399  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101154603  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101139742  PLAAT3; phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101139364  PLAAT2; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101133308  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
101146471  ETS1; protein C-ets-1 isoform X3 [KO:K02678]
101149999  ETS2; protein C-ets-2 isoform X2 [KO:K21932]
101152476  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
101133983  KSR1; kinase suppressor of Ras 1 isoform X3 [KO:K14958]
101147427  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
101150356  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
101125618  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
101125880  RAP1B; ras-related protein Rap-1b [KO:K07836]
101125007  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [KO:K05860] [EC:3.1.4.11]
101124828  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101150691  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101139074  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101143789  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
101127165  ABL1; tyrosine-protein kinase ABL1 isoform X3 [KO:K06619] [EC:2.7.10.2]
101134626  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
101144180  RAB5A; ras-related protein Rab-5A [KO:K07887]
101136077  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
101126272  RAB5C; ras-related protein Rab-5C isoform X2 [KO:K07889]
101129634  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X5 [KO:K25768]
101132604  INS; insulin isoform X1 [KO:K04526]
101133471  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
101133623  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101139013  CALM2; calmodulin-2 isoform X1 [KO:K02183]
101139939  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101146576  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
101148690  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X4 [KO:K05454]
101149474  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101154560  NF1; neurofibromin isoform X10 [KO:K08052]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
ggo04010  MAPK signaling pathway
ggo04015  Rap1 signaling pathway
ggo04020  Calcium signaling pathway
ggo04144  Endocytosis
ggo04151  PI3K-Akt signaling pathway
ggo04660  T cell receptor signaling pathway
ggo04720  Long-term potentiation
ggo04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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