KEGG   PATHWAY: mcc05165
Entry
mcc05165                    Pathway                                
Name
Human papillomavirus infection - Macaca mulatta (rhesus monkey)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcc05165  Human papillomavirus infection
mcc05165

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100187576  MAMU-AG; major histocompatibility complex, class I, AG precursor [KO:K06751]
100423838  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100424087  AXIN1; axin-1 isoform X1 [KO:K02157]
100424348  [KO:K06751]
100424899  [KO:K04632]
100425716  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100426197  [KO:K06751]
100427351  HES3; LOW QUALITY PROTEIN: transcription factor HES-3 [KO:K09088]
100427400  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100428484  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
100428736  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
100429346  [KO:K10389]
100429807  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
100430603  LAMA5; laminin subunit alpha-5 [KO:K06240]
106992270  ITGA9; integrin alpha-9 [KO:K06585]
106992322  [KO:K05414]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106995374  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
106995452  [KO:K06751]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
106996627  [KO:K06751]
106996676  [KO:K06751]
106997893  [KO:K06751]
114669841  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
114672663  [KO:K05414]
114672664  [KO:K05414]
114675385  [KO:K11126] [EC:2.7.7.49]
114675515  [KO:K14021]
114676051  [KO:K06751]
114677611  [KO:K02155]
114677644  [KO:K06751]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574201  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574276  THBS4; thrombospondin-4 [KO:K04659]
574294  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
574312  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
574315  ITGA5; integrin alpha-5 [KO:K06484]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574352  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
574378  TLR3; toll-like receptor 3 precursor [KO:K05401]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613269  FN1; fibronectin isoform X1 [KO:K05717]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
677865  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
693323  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
693357  [KO:K06238]
693419  WNT7A; protein Wnt-7a [KO:K00572]
693443  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
693797  CCNA1; cyclin-A1 isoform X3 [KO:K06627]
693838  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
693840  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
694069  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
694090  ITGA11; integrin alpha-11 [KO:K06587]
694248  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
694289  [KO:K04632]
694372  [KO:K06751]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694560  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
694601  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
694616  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
694625  FZD6; frizzled-6 precursor [KO:K02376]
694631  [KO:K05414]
694662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
694701  COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694929  HES5; transcription factor HES-5 isoform X1 [KO:K06055]
694965  TSC2; tuberin isoform X7 [KO:K07207]
695118  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
695190  CSNK1A1L; casein kinase I isoform alpha-like [KO:K08957] [EC:2.7.11.1]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
695220  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
696200  WNT3A; protein Wnt-3a [KO:K00312]
696258  TBP; TATA-box-binding protein [KO:K03120]
696274  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
696326  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
696336  PXN; paxillin isoform X1 [KO:K05760]
696350  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
696372  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
696663  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
696685  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
696845  WNT11; protein Wnt-11 isoform X2 [KO:K01384]
696992  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
697179  DLG3; disks large homolog 3 [KO:K21098]
697188  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
697371  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
697643  ITGA6; integrin alpha-6 precursor [KO:K06485]
697718  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
697742  PKM; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697799  PSMC1; proteasome (prosome, macropain) 26S subunit, ATPase, 1 [KO:K03062]
697863  MAML3; mastermind-like protein 3 [KO:K06061]
698092  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13 [KO:K05631]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
698345  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
698434  HES4; transcription factor HES-4 [KO:K09089]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698830  HRAS; GTPase HRas [KO:K02833]
698888  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
698943  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699163  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
699243  MAMU-A3; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
699351  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
699385  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
699405  ITGB7; integrin beta-7 [KO:K06590]
699479  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
699520  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
699530  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
700030  FOXO1; forkhead box protein O1 [KO:K07201]
700074  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
700086  CRB3; protein crumbs homolog 3 precursor [KO:K06090]
700090  TADA3; transcriptional adapter 3 [KO:K11315]
700141  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
700281  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
700359  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
700382  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
700454  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
700573  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
700589  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
700692  WNT10A; protein Wnt-10a [KO:K01357]
700962  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701313  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
701650  RBL1; LOW QUALITY PROTEIN: retinoblastoma-like protein 1 [KO:K04681]
701759  TCF7L2; transcription factor 7-like 2 isoform X9 [KO:K04491]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
701835  IBSP; bone sialoprotein 2 [KO:K06253]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702111  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
702112  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
702225  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
702243  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
702449  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
702601  CHAD; chondroadherin [KO:K06248]
702720  TNC; tenascin isoform X1 [KO:K06252]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
702945  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
703064  FZD7; frizzled-7 [KO:K02432]
703342  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
703404  HES2; transcription factor HES-2 [KO:K09087]
703456  ITGA1; integrin alpha-1 [KO:K06480]
703572  ITGA2; integrin alpha-2 precursor [KO:K06481]
703628  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
703646  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
703655  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
703707  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
703770  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
703814  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
703933  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
703942  FZD1; frizzled-1 [KO:K02432]
704331  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704745  ITGA4; integrin alpha-4 [KO:K06483]
704754  FZD4; frizzled-4 precursor [KO:K02354]
704826  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
704851  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
704871  RB1; retinoblastoma-associated protein [KO:K06618]
704930  SPP1; osteopontin precursor [KO:K06250]
704991  WNT2; protein Wnt-2 precursor [KO:K00182]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
705413  THBS1; thrombospondin-1 [KO:K16857]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705605  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
705692  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
705773  WNT2B; protein Wnt-2b [KO:K00182]
705864  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
706258  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
706472  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
706672  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
706673  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148]
706973  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
706988  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
707140  HES1; transcription factor HES-1 [KO:K06054]
707247  ITGB8; integrin beta-8 precursor [KO:K06591]
707259  CCNA2; cyclin-A2 [KO:K06627]
707279  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707345  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
707405  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
707756  ITGAV; integrin alpha-V precursor [KO:K06487]
707788  IRF1; interferon regulatory factor 1 [KO:K09444]
707864  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
707892  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
707977  KRAS; GTPase KRas [KO:K07827]
708165  THBS2; thrombospondin-2 [KO:K04659]
708287  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
708368  FZD8; frizzled-8 [KO:K02375]
708441  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
708499  VTN; vitronectin [KO:K06251]
708583  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
708587  TNN; tenascin-N isoform X1 [KO:K06252]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708707  TNR; tenascin-R [KO:K06252]
708717  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
708906  WNT10B; protein Wnt-10b precursor [KO:K01357]
708912  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709009  WNT1; proto-oncogene Wnt-1 [KO:K03209]
709076  MAMU-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
709089  NRAS; GTPase NRas [KO:K07828]
709493  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
709572  DLG1; disks large homolog 1 [KO:K12076]
709587  [KO:K11583]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709739  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
709755  IFNA8; interferon alpha-8 [KO:K05414]
709865  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
709947  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709958  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710049  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
710162  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
710234  TCF7; transcription factor 7 isoform X3 [KO:K02620]
710240  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
710242  WNT8B; protein Wnt-8b [KO:K00714]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710326  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
710340  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
710372  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
710387  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710487  [KO:K05414]
710528  [KO:K05414]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710568  [KO:K05414]
710650  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
710751  [KO:K05414]
710756  TUBG1; tubulin gamma-1 chain [KO:K10389]
710775  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
710796  FZD5; frizzled-5 [KO:K02375]
710798  [KO:K00873] [EC:2.7.1.40]
710848  [KO:K05414]
711002  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
711023  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
711088  [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
711270  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711414  IFNB1; interferon beta precursor [KO:K05415]
711532  MAMU-E; major histocompatibility complex, class I, E precursor [KO:K06751]
711832  MAMU-A; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
711920  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
711979  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
712004  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
712381  FZD2; frizzled-2 [KO:K02235]
712444  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
712644  [KO:K02153]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
712988  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713162  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X12 [KO:K11643] [EC:5.6.2.-]
713262  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
713391  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
713764  WNT8A; protein Wnt-8a [KO:K00714]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713798  NOTCH2; neurogenic locus notch homolog protein 2 precursor [KO:K20994]
713839  FZD3; frizzled-3 precursor [KO:K02329]
713864  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
714126  E2F1; transcription factor E2F1 [KO:K17454]
714381  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
714443  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
714645  TSC1; hamartin isoform X1 [KO:K07206]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714746  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
714809  COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131]
714955  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
714964  [KO:K06751]
714981  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
715047  MAML1; mastermind-like protein 1 [KO:K06061]
715186  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
715212  LAMC2; laminin subunit gamma-2 [KO:K06246]
715265  LAMC1; laminin subunit gamma-1 [KO:K05635]
715331  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
715378  RHEB; GTP-binding protein Rheb [KO:K07208]
715394  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
715467  TNF; tumor necrosis factor [KO:K03156]
715492  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
715710  ITGB5; integrin beta-5 precursor [KO:K06588]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715951  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716117  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716313  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
716392  FZD9; frizzled-9 [KO:K02842]
716671  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
716877  WNT9B; protein Wnt-9b [KO:K01064]
716909  WNT3; proto-oncogene Wnt-3 [KO:K00312]
716998  TNXB; tenascin-X isoform X7 [KO:K06252]
717078  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
717323  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
717379  ITGB3; integrin beta-3 [KO:K06493]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
717572  THBS3; thrombospondin-3 precursor [KO:K04659]
717625  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717812  FZD10; frizzled-10 [KO:K02842]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
718566  AXIN2; axin-2 isoform X1 [KO:K04385]
718580  JAG1; protein jagged-1 [KO:K06052]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718894  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X9 [KO:K11584]
718948  BAX; apoptosis regulator BAX [KO:K02159]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
719119  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
719250  [KO:K06751]
719263  PATJ; inaD-like protein isoform X1 [KO:K06092]
719319  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
719330  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
719331  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719702  [KO:K06751]
719929  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
719943  COL9A3; collagen alpha-3(IX) chain isoform X2 [KO:K08131]
720132  [KO:K06751]
720286  COMP; cartilage oligomeric matrix protein [KO:K04659]
720945  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
721685  WNT5B; protein Wnt-5b [KO:K00444]
721731  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721825  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
721855  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
721942  HES7; transcription factor HES-7 [KO:K09087]
722019  VWF; von Willebrand factor precursor [KO:K03900]
722026  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
722033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
722430  LAMC3; laminin subunit gamma-3 [KO:K06247]
722472  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
723473  [KO:K06751]
780935  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomaviruses and cell signaling.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Pathogens 5:E8 (2016)
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Viruses 7:3530-51 (2015)
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PDZ domains: the building blocks regulating tumorigenesis.
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Human tumour viruses and the deregulation of cell polarity in cancer.
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
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The evolving field of human papillomavirus receptor research: a review of binding and entry.
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J Virol 87:6062-72 (2013)
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Related
pathway
mcc04064  NF-kappa B signaling pathway
mcc04110  Cell cycle
mcc04115  p53 signaling pathway
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04310  Wnt signaling pathway
mcc04330  Notch signaling pathway
mcc04510  Focal adhesion
mcc04520  Adherens junction
mcc04530  Tight junction
mcc04612  Antigen processing and presentation
mcc04620  Toll-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
KO pathway
ko05165   

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