KEGG   PATHWAY: mcoc04015
Entry
mcoc04015                   Pathway                                
Name
Rap1 signaling pathway - Mastomys coucha (southern multimammate mouse)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcoc04015  Rap1 signaling pathway
mcoc04015

Other DBs
GO: 0007264
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067948  Enah; protein enabled homolog isoform X1 [KO:K05746]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116068700  Actb; actin, cytoplasmic 1 [KO:K05692]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116068780  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116068825  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116068986  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116069116  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116069430  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116069565  F2rl3; proteinase-activated receptor 4 isoform X1 [KO:K04236]
116069817  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116069889  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116069997  [KO:K02183]
116070066  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
116070104  Cdh1; cadherin-1 [KO:K05689]
116070207  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116070416  Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
116070446  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116071281  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116071284  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116072312  Mras; ras-related protein M-Ras [KO:K07831]
116072321  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116072449  Tln2; talin-2 isoform X1 [KO:K06271]
116073403  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
116073523  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116073724  Ctnnb1; catenin beta-1 [KO:K02105]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116074581  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
116074720  [KO:K05448]
116074875  Itgb2; integrin beta-2 [KO:K06464]
116075043  Adora2a; adenosine receptor A2a [KO:K04266]
116075101  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116075516  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116075736  Rap1b; ras-related protein Rap-1b [KO:K07836]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116076329  [KO:K04513]
116076345  Efna2; ephrin-A2 [KO:K05462]
116076407  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116076467  Kitlg; kit ligand isoform X1 [KO:K05461]
116076778  Adora2b; adenosine receptor A2b [KO:K04267]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116076922  Itgb3; integrin beta-3 [KO:K06493]
116077083  Lcp2; lymphocyte cytosolic protein 2 [KO:K07361]
116077765  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077791  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077938  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116078214  Itga2b; integrin alpha-IIb [KO:K06476]
116078310  Afdn; afadin isoform X1 [KO:K05702]
116078343  Pfn1; profilin-1 [KO:K05759]
116078356  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116078746  Rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
116078777  Actg1; actin, cytoplasmic 2 [KO:K05692]
116078814  Crk; adapter molecule crk isoform X1 [KO:K04438]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116079000  Skap1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
116079067  Adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
116079135  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116079141  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
116079663  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116079667  Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
116079748  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116079808  Calm1; calmodulin-1 [KO:K02183]
116079820  Pgf; placenta growth factor [KO:K16859]
116079993  Calm2; calmodulin-2 [KO:K02183]
116080295  Pfn4; profilin-4 isoform X1 [KO:K05759]
116080333  Evl; ena/VASP-like protein isoform X1 [KO:K23487]
116080624  Prkd1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
116080797  Dock4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
116080810  Rapgef5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
116080861  Prkd3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
116081427  Rala; ras-related protein Ral-A [KO:K07834]
116081648  Pfn3; profilin-3 [KO:K05759]
116081777  [KO:K02183]
116082049  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116082366  Rgs14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
116082411  [KO:K02183]
116082804  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116083372  F2r; proteinase-activated receptor 1 [KO:K03914]
116083593  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116083931  Fyb1; FYN-binding protein 1 isoform X1 [KO:K17698]
116084111  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116084142  [KO:K10784]
116084214  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116084801  [KO:K10784]
116084963  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116085656  Crkl; crk-like protein [KO:K04438]
116085856  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116086106  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116086631  [KO:K06464]
116087072  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116087228  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116087400  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
116087975  Cnr1; cannabinoid receptor 1 [KO:K04277]
116088074  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
116088575  [KO:K05759]
116088803  Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
116088835  Efna5; ephrin-A5 isoform X1 [KO:K05462]
116089766  Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
116089804  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116089883  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116089898  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
116089919  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
116090303  Rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
116090392  Ctnnd1; catenin delta-1 isoform X1 [KO:K05690]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116090684  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
116090695  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116090998  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090999  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116091151  Angpt4; angiopoietin-4 [KO:K05467]
116091178  Id1; DNA-binding protein inhibitor ID-1 isoform X1 [KO:K04680]
116091289  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116091317  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116091495  [KO:K04632]
116091496  [KO:K04632]
116091834  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
116092905  Pfn2; profilin-2 [KO:K05759]
116092927  [KO:K04353]
116092937  P2ry1; P2Y purinoceptor 1 [KO:K04270]
116093009  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116093165  Efna1; ephrin-A1 isoform X1 [KO:K05462]
116093166  Efna3; ephrin-A3 isoform X1 [KO:K05462]
116093175  Efna4; ephrin-A4 [KO:K05462]
116093520  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
116093530  Nras; GTPase NRas [KO:K07828]
116093545  Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
116093571  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
116093601  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116093617  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116093653  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116093916  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116095037  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116095810  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
116095900  Tln1; talin-1 [KO:K06271]
116096072  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
116096241  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116096883  Rap1gap; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
116096958  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097451  Krit1; krev interaction trapped protein 1 [KO:K17705]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116097497  [KO:K04630]
116097498  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
116097777  Ralb; ras-related protein Ral-B [KO:K07835]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116098774  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116098819  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
116099290  [KO:K05692]
116099295  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116099597  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
116099710  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116100904  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116101481  [KO:K04526]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116101690  Prkd2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
116101711  Calm3; calmodulin-3 [KO:K02183]
116101743  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116101949  Sipa1l3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
116102164  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116102663  [KO:K02183]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116103005  Itgal; integrin alpha-L isoform X1 [KO:K05718]
116103050  Itgam; integrin alpha-M isoform X1 [KO:K06461]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116103406  Sipa1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
116103453  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116103465  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116103624  [KO:K04634]
116103808  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04014  Ras signaling pathway
mcoc04020  Calcium signaling pathway
mcoc04151  PI3K-Akt signaling pathway
mcoc04510  Focal adhesion
mcoc04520  Adherens junction
mcoc04660  T cell receptor signaling pathway
mcoc04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

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