KEGG   PATHWAY: mlx04020
Entry
mlx04020                    Pathway                                
Name
Calcium signaling pathway - Mirounga leonina (Southern elephant seal)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mlx04020  Calcium signaling pathway
mlx04020

Other DBs
GO: 0019722
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
117997961  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117997993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117998046  FGF21; fibroblast growth factor 21 [KO:K22429]
117998176  CALM3; calmodulin-3 [KO:K02183]
117998202  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
117998224  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
117998504  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117998664  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
117998905  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
117999123  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117999262  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117999455  ORAI2; protein orai-2 isoform X1 [KO:K16057]
117999543  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
117999577  ORAI3; protein orai-3 [KO:K16058]
117999585  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
117999657  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117999806  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
117999859  ADORA2A; adenosine receptor A2a [KO:K04266]
118000116  ADORA2B; adenosine receptor A2b [KO:K04267]
118000486  CASQ2; calsequestrin-2 [KO:K23445]
118000488  NGF; beta-nerve growth factor [KO:K02582]
118000615  PLN; cardiac phospholamban [KO:K05852]
118000678  TRDN; triadin [KO:K23449]
118001000  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
118001326  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118001520  TFEB; transcription factor EB [KO:K15590]
118001628  VEGFA; vascular endothelial growth factor A [KO:K05448]
118001874  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
118002013  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
118002481  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
118002566  CALM1; calmodulin-1 [KO:K02183]
118002666  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
118003092  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
118003137  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118003200  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118003420  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
118003624  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
118003690  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
118003693  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118003737  RYR3; ryanodine receptor 3 [KO:K04963]
118003738  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118003872  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
118004189  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
118004524  [KO:K05862]
118004651  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118004880  OXTR; oxytocin receptor [KO:K04229]
118004937  AGTR1; type-1 angiotensin II receptor [KO:K04166]
118005070  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118005092  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
118005157  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
118005208  [KO:K05214]
118005236  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118005531  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
118005532  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
118005534  TBXA2R; thromboxane A2 receptor [KO:K04264]
118005558  MST1; hepatocyte growth factor-like protein [KO:K23441]
118005799  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
118005929  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
118005966  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118005979  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
118006021  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
118006030  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
118006038  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
118006050  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118006264  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118006370  [KO:K05452]
118006439  [KO:K04358]
118006498  [KO:K05452]
118006573  [KO:K04358]
118006598  [KO:K04515] [EC:2.7.11.17]
118006623  [KO:K04142]
118006646  [KO:K04160]
118006692  [KO:K05089] [EC:2.7.10.1]
118006728  [KO:K04515] [EC:2.7.11.17]
118006771  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
118006789  ADRB2; beta-2 adrenergic receptor [KO:K04142]
118006827  [KO:K05089] [EC:2.7.10.1]
118006945  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
118007012  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
118007070  GRPR; gastrin-releasing peptide receptor [KO:K04169]
118007336  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
118007465  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
118007652  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118007805  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
118007934  TACR1; substance-P receptor [KO:K04222]
118007998  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118008037  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
118008161  CALM2; calmodulin-2 [KO:K02183]
118008633  AVPR1A; vasopressin V1a receptor [KO:K04226]
118008728  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118008752  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
118008972  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118009316  EDNRB; endothelin receptor type B [KO:K04198]
118009426  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
118009441  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
118009553  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118009586  FGF9; fibroblast growth factor 9 [KO:K04358]
118009863  FGF20; fibroblast growth factor 20 [KO:K04358]
118009917  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118009956  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118009967  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
118010066  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118010093  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
118010198  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
118010274  CCKAR; cholecystokinin receptor type A [KO:K04194]
118010291  DRD5; D(1B) dopamine receptor [KO:K05840]
118010519  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118010522  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118010636  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
118010687  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118010795  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118011154  TNNC2; troponin C, skeletal muscle [KO:K12042]
118011244  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118011247  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118011279  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
118011350  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118011377  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
118011488  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118011842  [KO:K04161]
118011956  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
118012040  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
118012082  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
118012254  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
118012355  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118012486  [KO:K02183]
118012497  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118012526  [KO:K15041]
118012943  RYR2; ryanodine receptor 2 [KO:K04962]
118012948  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118013021  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
118013160  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118013181  SLN; sarcolipin [KO:K22642]
118013460  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
118013664  AVPR1B; vasopressin V1b receptor [KO:K04227]
118013781  CASQ1; calsequestrin-1 [KO:K23468]
118013921  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118014170  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118014221  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118014278  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
118014352  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
118014859  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
118014964  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
118015126  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
118015219  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118015629  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118015651  FGF4; fibroblast growth factor 4 [KO:K04358]
118015751  DRD1; D(1A) dopamine receptor [KO:K04144]
118015761  HRH2; histamine H2 receptor [KO:K04150]
118015857  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
118015992  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118015997  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118016156  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
118016161  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
118016328  FGF19; fibroblast growth factor 19 [KO:K22603]
118016329  FGF3; fibroblast growth factor 3 [KO:K04358]
118016596  [KO:K02183]
118016634  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118016658  FGF18; fibroblast growth factor 18 [KO:K04358]
118016762  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118016916  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
118017149  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118017467  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
118017609  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118017873  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
118017875  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
118018168  [KO:K04223]
118018172  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
118018306  P2RX2; P2X purinoceptor 2 [KO:K05216]
118018437  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
118018447  P2RX7; P2X purinoceptor 7 [KO:K05220]
118018450  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
118018451  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118018496  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
118018518  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118018945  [KO:K04223]
118019212  MCOLN3; mucolipin-3 [KO:K04994]
118019214  MCOLN2; mucolipin-2 [KO:K04993]
118019227  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118019241  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
118019274  PTGER3; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP3 subtype [KO:K04260]
118019292  [KO:K22643]
118019658  CALML6; calmodulin-like protein 6 [KO:K02183]
118019771  [KO:K22643]
118019805  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
118020319  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118020685  HGF; hepatocyte growth factor [KO:K05460]
118020691  [KO:K02183]
118020821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118020939  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
118021010  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118021391  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118021446  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
118021556  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118021581  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
118021620  CALML3; calmodulin-like protein 3 [KO:K02183]
118021683  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
118021697  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118021775  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
118021822  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118021903  [KO:K02183]
118021936  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118022080  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118022108  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
118022110  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
118022199  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118022209  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
118022264  EDNRA; endothelin-1 receptor [KO:K04197]
118022338  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118022368  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118022565  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
118022645  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
118022771  RYR1; ryanodine receptor 1 [KO:K04961]
118022967  [KO:K04809]
118023033  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
118023087  [KO:K04632]
118023317  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118023401  [KO:K04282]
118023454  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118023528  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118023561  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
118023644  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118023800  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118023818  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
118023826  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
118023942  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
118023976  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118024008  [KO:K04632]
118024010  [KO:K04632]
118024039  NTSR1; neurotensin receptor type 1 [KO:K04211]
118024239  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
118024267  SMIM6; small integral membrane protein 6 [KO:K26468]
118024295  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
118024347  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118024497  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
118024512  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118024535  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118024757  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118024846  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118025159  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
118025163  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118025169  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
118025303  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118025471  PLCZ1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
118025498  FGF23; fibroblast growth factor 23 [KO:K22428]
118025560  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118025638  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118025764  FGF6; fibroblast growth factor 6 [KO:K04358]
118025809  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118025945  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
118026033  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
118026046  FGF16; fibroblast growth factor 16 [KO:K04358]
118026266  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118026271  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
118026436  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
118026502  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118026567  ADRB1; beta-1 adrenergic receptor [KO:K04141]
118026668  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118026787  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
118026800  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118027011  TACR3; neuromedin-K receptor [KO:K04224]
118027044  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118027092  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118027107  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118027135  CUNH4orf3; uncharacterized protein C4orf3 homolog isoform X1 [KO:K26467]
118027178  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
118027388  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mlx04010  MAPK signaling pathway
mlx04070  Phosphatidylinositol signaling system
mlx04210  Apoptosis
mlx04720  Long-term potentiation
mlx04730  Long-term depression
KO pathway
ko04020   

DBGET integrated database retrieval system