KEGG   PATHWAY: mlx04510
Entry
mlx04510                    Pathway                                
Name
Focal adhesion - Mirounga leonina (Southern elephant seal)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mlx04510  Focal adhesion
mlx04510

Other DBs
GO: 0005925
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
117997741  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
117997778  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
117997993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117998144  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117998186  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
117998585  PARVG; gamma-parvin [KO:K06275]
117998586  PARVB; beta-parvin isoform X1 [KO:K06275]
117998664  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
117998715  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
117998812  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117999123  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117999242  MYL10; myosin regulatory light chain 10 [KO:K12756]
117999262  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117999316  ACTB; actin, cytoplasmic 1 [KO:K05692]
117999338  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117999604  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999812  CRKL; crk-like protein [KO:K04438]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118000263  ITGA10; integrin alpha-10 [KO:K06586]
118000335  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
118000741  LAMA2; laminin subunit alpha-2 [KO:K05637]
118000764  [KO:K06272] [EC:2.7.11.1]
118000978  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
118001139  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
118001612  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
118001619  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
118001628  VEGFA; vascular endothelial growth factor A [KO:K05448]
118001778  [KO:K04659]
118001833  ITGA9; integrin alpha-9 [KO:K06585]
118001902  [KO:K04659]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118002069  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118002257  PGF; placenta growth factor isoform X1 [KO:K16859]
118002288  CTNNB1; catenin beta-1 [KO:K02105]
118002543  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
118002902  [KO:K13709]
118002910  [KO:K13709]
118002971  SHC4; SHC-transforming protein 4 [KO:K17449]
118002986  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
118003019  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118003402  TLN2; talin-2 isoform X1 [KO:K06271]
118003458  [KO:K06238]
118003466  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
118003477  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118003756  THBS1; thrombospondin-1 [KO:K16857]
118004113  PARVA; alpha-parvin isoform X1 [KO:K06275]
118004217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118004254  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
118004378  [KO:K12757]
118004379  [KO:K12757]
118004389  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118004427  LAMA1; laminin subunit alpha-1 [KO:K05637]
118004574  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118004707  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118004774  [KO:K04393]
118004859  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
118004996  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
118005192  FLNB; filamin-B isoform X1 [KO:K27392]
118005319  CAV3; caveolin-3 [KO:K12959]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118005519  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
118005658  COMP; cartilage oligomeric matrix protein [KO:K04659]
118005670  RHOA; transforming protein RhoA [KO:K04513]
118005984  LAMB2; laminin subunit beta-2 [KO:K06243]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118006650  [KO:K06480]
118006689  [KO:K06481]
118006692  [KO:K05089] [EC:2.7.10.1]
118006776  [KO:K06480]
118006810  [KO:K06481]
118006827  [KO:K05089] [EC:2.7.10.1]
118006945  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
118006973  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118007005  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
118007012  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
118007057  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118007595  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118007723  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118007794  SOS1; son of sevenless homolog 1 [KO:K03099]
118008509  COL2A1; collagen alpha-1(II) chain [KO:K19719]
118008531  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
118008596  RAP1B; ras-related protein Rap-1b [KO:K07836]
118008748  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118008757  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118008801  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118009236  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
118009237  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
118009553  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118009849  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
118010093  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
118010349  SPP1; osteopontin isoform X1 [KO:K06250]
118010352  IBSP; bone sialoprotein 2 [KO:K06253]
118010368  [KO:K04440] [EC:2.7.11.24]
118010439  [KO:K04353]
118010519  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118010522  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118010819  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
118011242  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118011345  [KO:K04393]
118011350  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118011444  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
118011463  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
118011895  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
118011976  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
118011978  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
118011980  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
118011987  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
118012071  FN1; fibronectin isoform X1 [KO:K05717]
118012112  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
118012237  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118012261  ITGA4; integrin alpha-4 [KO:K06483]
118012328  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118012407  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118012582  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
118012969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118012992  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118013143  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
118013146  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118013160  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118013864  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
118013877  THBS3; thrombospondin-3 [KO:K04659]
118014193  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
118014280  LAMB3; laminin subunit beta-3 [KO:K06244]
118014371  LAMC1; laminin subunit gamma-1 [KO:K05635]
118014372  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
118014437  TNR; tenascin-R [KO:K06252]
118014453  TNN; tenascin-N [KO:K06252]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118014658  FLNA; filamin-A isoform X1 [KO:K04437]
118015244  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118015992  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
118016125  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
118016166  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118016733  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118016945  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
118017539  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
118017569  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
118017766  TNC; tenascin isoform X1 [KO:K06252]
118017969  TLN1; talin-1 isoform X1 [KO:K06271]
118018107  LAMC3; laminin subunit gamma-3 [KO:K06247]
118018155  [KO:K04392]
118018468  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
118018471  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
118018538  PXN; paxillin isoform X1 [KO:K05760]
118019003  RAP1A; ras-related protein Rap-1A [KO:K04353]
118019063  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
118019356  JUN; transcription factor AP-1 [KO:K04448]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118019571  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118019913  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118020609  LAMB1; laminin subunit beta-1 [KO:K05636]
118020611  LAMB4; laminin subunit beta-4 [KO:K06245]
118020651  RELN; reelin [KO:K06249] [EC:3.4.21.-]
118020685  HGF; hepatocyte growth factor [KO:K05460]
118020776  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118020850  ITGB8; integrin beta-8 [KO:K06591]
118021007  CAV2; caveolin-2 [KO:K12958]
118021009  CAV1; caveolin-1 isoform X1 [KO:K06278]
118021010  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118021159  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118021202  ZYX; zyxin [KO:K06273]
118021548  ITGA8; integrin alpha-8 [KO:K06584]
118021736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118021799  VCL; vinculin isoform X1 [KO:K05700]
118021823  EMP2; epithelial membrane protein 2 [KO:K26256]
118022209  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118022679  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
118022694  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118023006  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118023210  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
118023562  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
118023826  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
118024031  LAMA5; laminin subunit alpha-5 [KO:K06240]
118024036  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118024176  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118024262  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118024266  [KO:K12757]
118024273  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118024347  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118024428  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118024535  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118024560  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
118024764  CHAD; chondroadherin [KO:K06248]
118024771  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118024776  ITGA3; integrin alpha-3 [KO:K06482]
118024846  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118024979  ITGA2B; integrin alpha-IIb [KO:K06476]
118025226  CRK; adapter molecule crk isoform X1 [KO:K04438]
118025294  VTN; vitronectin [KO:K06251]
118025641  EMP1; epithelial membrane protein 1 [KO:K26255]
118025754  VWF; von Willebrand factor [KO:K03900]
118025766  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118026255  SHC3; SHC-transforming protein 3 [KO:K17448]
118026317  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
118026502  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026614  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118026936  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
118026938  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118027092  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118027184  ITGB3; integrin beta-3 [KO:K06493]
118027196  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
118027388  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mlx04010  MAPK signaling pathway
mlx04060  Cytokine-cytokine receptor interaction
mlx04070  Phosphatidylinositol signaling system
mlx04110  Cell cycle
mlx04151  PI3K-Akt signaling pathway
mlx04310  Wnt signaling pathway
mlx04512  ECM-receptor interaction
mlx04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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