Entry
Name
NOD-like receptor signaling pathway - Ailuropoda melanoleuca (giant panda)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
aml04621 NOD-like receptor signaling pathway
Ortholog table
Organism
Ailuropoda melanoleuca (giant panda) [GN:
aml ]
Gene
100479663 NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
100467906 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100466241 growth-regulated protein homolog gamma-like isoform X1 [KO:K05505 ]
100469482 NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165 ]
100484077 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403 ]
100468085 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
100464125 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
100471461 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
100480510 GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
100480205 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
100468657 MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
100484167 MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
100477810 MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
117803533 microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435 ]
100471523 CARD6; caspase recruitment domain-containing protein 6 [KO:K12797 ]
100477152 baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060 ]
100484878 CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
100482674 MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648 ]
100484543 TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650 ]
100474086 IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447 ]
100478521 ANTXR1; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909 ]
100481297 NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798 ]
100475582 apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
100468792 NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
100479364 TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977 ] [EC:3.6.1.13 ]
100482433 TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982 ] [EC:2.7.11.1 ]
100483855 TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971 ]
100476076 GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622 ]
100481755 PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
100474779 PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
100467161 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958 ]
100477888 ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
100463625 VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
100465507 VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
100470763 VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
100475721 MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858 ]
100469504 RNASEL; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165 ]
100475188 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X3 [KO:K11864 ] [EC:3.4.19.-]
100471414 HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079 ]
100467363 HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079 ]
117803466 LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079 ]
100474378 CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801 ]
100464289 immunity-related GTPase family M protein 1 isoform X1 [KO:K14139 ] [EC:3.6.5.-]
100463703 immunity-related GTPase family M protein 1-like isoform X1 [KO:K14139 ] [EC:3.6.5.-]
117801422 LOW QUALITY PROTEIN: immunity-related GTPase family M protein 1-like [KO:K14139 ] [EC:3.6.5.-]
100473221 PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804 ]
100469211 NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863 ]
100465031 NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865 ]
105236112 NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807 ]
100464785 NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805 ]
100475592 myeloid cell nuclear differentiation antigen-like protein isoform X1 [KO:K20914 ]
100474026 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
100472167 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
100479307 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
100473848 STING1; stimulator of interferon genes protein isoform X2 [KO:K12654 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Vandenabeele P, Bertrand MJ
Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
Journal
Reference
Authors
Strober W, Murray PJ, Kitani A, Watanabe T
Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
Journal
Reference
Authors
Estornes Y, Bertrand MJ
Title
IAPs, regulators of innate immunity and inflammation.
Journal
Reference
Authors
Jakopin Z
Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
Journal
Reference
Authors
Caruso R, Warner N, Inohara N, Nunez G
Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Journal
Reference
Authors
Murray PJ
Title
Beyond peptidoglycan for Nod2.
Journal
Reference
Authors
Lecat A, Piette J, Legrand-Poels S
Title
The protein Nod2: an innate receptor more complex than previously assumed.
Journal
Reference
Authors
Man SM, Kanneganti TD
Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
Journal
Reference
Authors
Broz P, Dixit VM
Title
Inflammasomes: mechanism of assembly, regulation and signalling.
Journal
Reference
Authors
Man SM, Kanneganti TD
Title
Regulation of inflammasome activation.
Journal
Reference
Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
Journal
Reference
Authors
Broz P, Monack DM
Title
Newly described pattern recognition receptors team up against intracellular pathogens.
Journal
Reference
Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
Title
Regulation of inflammasome signaling.
Journal
Reference
Authors
Sutterwala FS, Haasken S, Cassel SL
Title
Mechanism of NLRP3 inflammasome activation.
Journal
Reference
Authors
Latz E, Xiao TS, Stutz A
Title
Activation and regulation of the inflammasomes.
Journal
Reference
Authors
Blander JM
Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
Journal
Reference
Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
Title
Recognition of bacteria by inflammasomes.
Journal
Reference
Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
Journal
Reference
Authors
Storek KM, Monack DM
Title
Bacterial recognition pathways that lead to inflammasome activation.
Journal
Reference
Authors
Hu H, Sun SC
Title
Ubiquitin signaling in immune responses.
Journal
Reference
Authors
Guo H, Callaway JB, Ting JP
Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
Journal
Reference
Authors
Man SM, Kanneganti TD
Title
Gasdermin D: the long-awaited executioner of pyroptosis.
Journal
Reference
Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Journal
Reference
Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
Journal
Reference
Authors
Heilig R, Broz P
Title
Function and mechanism of the pyrin inflammasome.
Journal
Reference
Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
Title
RNase L activates the NLRP3 inflammasome during viral infections.
Journal
Related pathway
aml04620 Toll-like receptor signaling pathway
KO pathway
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