KEGG   PATHWAY: bbub05167
Entry
bbub05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Bubalus bubalis (water buffalo)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05167

Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102407588  C3; complement C3 [KO:K03990]
102394367  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
102402850  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102402262  TRAF3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
102398659  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
102403644  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102393818  interferon alpha-H-like [KO:K05414]
102393701  interferon alpha-F [KO:K05414]
112583867  interferon alpha-H-like [KO:K05414]
102416204  interferon alpha-H [KO:K05414]
102402789  interferon alpha-H-like [KO:K05414]
112583876  interferon alpha-H-like [KO:K05414]
112583880  interferon alpha-B [KO:K05414]
102415114  interferon alpha-B-like [KO:K05414]
102414434  interferon alpha-H [KO:K05414]
112583541  interferon alpha-H [KO:K05414]
112577736  interferon alpha-H-like [KO:K05414]
112583544  interferon alpha-H [KO:K05414]
112583546  interferon alpha-H [KO:K05414]
112583548  interferon alpha-H-like [KO:K05414]
112583545  interferon alpha-B-like [KO:K05414]
102396674  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102403750  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
102394197  EP300; histone acetyltransferase p300 isoform X4 [KO:K04498] [EC:2.3.1.48]
112583883  interferon beta-3 [KO:K05415]
112583884  interferon beta-3 [KO:K05415]
112583885  interferon beta-3-like [KO:K05415]
112583886  interferon beta-3 [KO:K05415]
102402056  interferon beta-2 [KO:K05415]
102408434  interferon beta-3 [KO:K05415]
102402367  interferon beta-3-like [KO:K05415]
102402697  interferon beta-2 [KO:K05415]
123332785  interferon beta-3-like [KO:K05415]
123465588  interferon beta-3-like [KO:K05415]
123465589  interferon beta-3-like [KO:K05415]
102394317  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102394946  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102405285  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102402213  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102415500  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
102414314  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
102395411  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102391649  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
102409665  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102397149  MAPK14; mitogen-activated protein kinase 14 isoform X4 [KO:K04441] [EC:2.7.11.24]
102397694  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102401914  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102403288  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102415101  IL6; interleukin-6 isoform X1 [KO:K05405]
102413568  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
102392809  CCR3; C-C chemokine receptor type 3 [KO:K04178]
123327493  C-C chemokine receptor type 5 [KO:K04180]
102392270  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102391941  C-C chemokine receptor type 1 [KO:K04176]
102389630  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102393323  CCR8; C-C chemokine receptor type 8 [KO:K04183]
102408756  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102397985  FADD; FAS-associated death domain protein [KO:K02373]
102412929  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102399521  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
102400076  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102403948  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102391189  cytochrome c [KO:K08738]
112581627  cytochrome c 2 [KO:K08738]
102412012  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102415768  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102398200  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102416185  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102395129  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
102399613  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
102398886  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102394706  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
102412626  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102403930  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
102397938  RELA; transcription factor P65 [KO:K04735]
102402069  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
102403077  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102412787  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102407325  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
102400134  RB1; retinoblastoma-associated protein [KO:K06618]
123464883  E2F1; transcription factor E2F1 [KO:K17454]
102403332  E2F2; transcription factor E2F2 [KO:K09389]
102394305  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102393680  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102394332  BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
102410916  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X3 [KO:K06751]
102412769  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X3 [KO:K06751]
102394968  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102390435  BOLA class I histocompatibility antigen, alpha chain BL3-6 isoform X1 [KO:K06751]
102398125  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X2 [KO:K06751]
102402481  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102413969  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102392615  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
102406719  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102412126  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102410135  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102412516  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
102406557  CD86; T-lymphocyte activation antigen CD86 isoform X2 [KO:K05413]
102394643  MHC class I polypeptide-related sequence B isoform X1 [KO:K07985]
102403138  C-type lectin domain family 2 member B [KO:K10071]
102410983  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
102405730  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
102391818  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
102414937  ubiquitin-40S ribosomal protein S27a [KO:K02977]
112579681  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
112584441  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
102410559  UBC; polyubiquitin-C [KO:K08770]
102393899  BECN2; beclin-2 [KO:K08334]
102406464  BECN1; beclin-1 isoform X1 [KO:K08334]
102392566  ATG14; beclin 1-associated autophagy-related key regulator isoform X2 [KO:K17889]
102404618  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102389619  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
102392614  MAP1LC3C; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102398090  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
123464880  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
102406849  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102399170  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102414827  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102399967  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102400794  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102412203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102393962  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102405602  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X2 [KO:K04541]
102411670  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102402000  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
102406523  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
102410454  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102403796  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102401812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102402691  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
102396193  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102408374  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
102402143  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
102409522  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112587129  GTPase HRas-like [KO:K02833]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102399487  NRAS; GTPase NRas isoform X2 [KO:K07828]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102401744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102392717  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
102405224  JUN; transcription factor AP-1 [KO:K04448]
102393791  FOS; proto-oncogene C-Fos [KO:K04379]
102413532  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
102399362  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
102397321  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X7 [KO:K21290]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102395384  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102407977  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102408164  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
102392559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102393434  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102396572  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
102403452  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
102390732  cell surface glycoprotein CD200 receptor 1 [KO:K21668]
102391055  cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
102412306  SYK; tyrosine-protein kinase SYK isoform X2 [KO:K05855] [EC:2.7.10.2]
102410133  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102410643  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
102394691  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
102395178  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
102404881  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102396307  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102400354  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
102412452  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
102401062  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
102409793  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102391725  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102403292  calmodulin-1-like [KO:K02183]
102416387  calmodulin [KO:K02183]
102405655  calmodulin [KO:K02183]
102393421  calmodulin-1-like [KO:K02183]
102408582  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123466194  calmodulin-1-like [KO:K02183]
102396094  CALM1; calmodulin-1 isoform X2 [KO:K02183]
102406525  CALM3; calmodulin-3 [KO:K02183]
102410813  CALM2; calmodulin-2 [KO:K02183]
102400064  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102415631  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102414534  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
102400804  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102413480  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X3 [KO:K04446]
102396612  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X5 [KO:K17332]
102390438  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102404650  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
102412933  CXCL8; interleukin-8 precursor [KO:K10030]
102416528  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102415247  growth-regulated protein homolog gamma [KO:K05505]
102415899  growth-regulated alpha protein [KO:K05505]
102416225  growth-regulated protein homolog beta [KO:K05505]
102393090  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
102393273  FGF2; fibroblast growth factor 2 [KO:K18497]
102396324  VEGFA; vascular endothelial growth factor A [KO:K05448]
102396940  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102412552  ANGPT2; angiopoietin-2 [KO:K05466]
102405590  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
102412645  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102414888  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102401080  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
102396277  CTNNB1; catenin beta-1 [KO:K02105]
102408996  TCF7; transcription factor 7 isoform X2 [KO:K02620]
102410081  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
102393101  TCF7L2; transcription factor 7-like 2 isoform X10 [KO:K04491]
102409520  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
102401906  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102411133  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102402664  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
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J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
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Choi YB, Nicholas J
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Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
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J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
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McCormick C, Ganem D
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The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
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PMID:15967719
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Wang HW, Boshoff C
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Linking Kaposi virus to cancer-associated cytokines.
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Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
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Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
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Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
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Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
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PMID:10510092
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Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
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J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
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Chaudhary PM, Jasmin A, Eby MT, Hood L
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Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
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Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
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Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
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KSHV vFLIP binds to IKK-gamma to activate IKK.
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J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
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Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
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Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
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Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
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Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
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Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
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PMID:11413168
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
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How human tumor viruses make use of autophagy.
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Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
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PMID:10354594
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Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
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PMID:9594662
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  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
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PMID:12770701
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Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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FEMS Microbiol Lett 222:155-63 (2003)
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PMID:11960692
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Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
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Reference
PMID:10987301
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Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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Abere B, Schulz TF
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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PMID:15573137
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Sodhi A, Montaner S, Gutkind JS
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Viral hijacking of G-protein-coupled-receptor signalling networks.
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
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PMID:17329974
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Montaner S
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Cell Cycle 6:438-43 (2007)
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PMID:23028325
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Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
PMID:10318948
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Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
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PMID:26192396
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Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
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Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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Reference
PMID:25187543
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
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PMID:16585191
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
PMID:22521915
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
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Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
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pathway
bbub04010  MAPK signaling pathway
bbub04064  NF-kappa B signaling pathway
bbub04110  Cell cycle
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bbub04144  Endocytosis
bbub04151  PI3K-Akt signaling pathway
bbub04210  Apoptosis
bbub04310  Wnt signaling pathway
bbub04610  Complement and coagulation cascades
bbub04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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