KEGG   PATHWAY: btax05167
Entry
btax05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Budorcas taxicolor (takin)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
btax05167  Kaposi sarcoma-associated herpesvirus infection
btax05167

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128050332  complement C3 [KO:K03990]
128050333  complement C3-like [KO:K03990]
128068349  TLR3; toll-like receptor 3 [KO:K05401]
128050916  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
128051762  LOW QUALITY PROTEIN: TNF receptor-associated factor 3-like [KO:K03174]
128066664  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
128061603  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
128047841  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
128068703  IRF7; interferon regulatory factor 7 [KO:K09447]
128052429  interferon alpha-H-like [KO:K05414]
128052430  interferon alpha-H-like [KO:K05414]
128052431  interferon alpha-H [KO:K05414]
128052432  interferon alpha-1-like [KO:K05414]
128052433  interferon alpha-H-like [KO:K05414]
128052459  interferon alpha-H-like [KO:K05414]
128052476  interferon alpha-H-like [KO:K05414]
128052682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
128052694  interferon alpha-H-like [KO:K05414]
128052696  interferon alpha-H-like [KO:K05414]
128052697  interferon alpha-1-like [KO:K05414]
128052706  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
128062922  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
128043638  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
128047516  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
128052625  interferon beta-2-like [KO:K05415]
128052626  interferon beta-2-like [KO:K05415]
128052627  interferon beta-2-like [KO:K05415]
128052628  interferon beta-2 [KO:K05415]
128052635  interferon beta-2-like [KO:K05415]
128052636  interferon beta-2-like [KO:K05415]
128052637  interferon beta-2-like [KO:K05415]
128052638  interferon beta-2-like [KO:K05415]
128052639  interferon beta-2-like [KO:K05415]
128052640  interferon beta-2-like [KO:K05415]
128052652  interferon beta-2-like [KO:K05415]
128044048  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
128055500  interferon alpha/beta receptor 2 [KO:K05131]
128044816  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
128050301  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
128071221  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
128047300  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
128054182  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
128056687  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128061864  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
128065178  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128063128  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
128046952  IL6; interleukin-6 [KO:K05405]
128051607  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
128049678  CCR3; C-C chemokine receptor type 3 [KO:K04178]
128049778  C-C chemokine receptor type 5 [KO:K04180]
128051420  C-C chemokine receptor type 1 [KO:K04176]
128054958  LOW QUALITY PROTEIN: C-C chemokine receptor type 1-like [KO:K04176]
128055689  CCR4; C-C chemokine receptor type 4 [KO:K04179]
128057171  CCR8; C-C chemokine receptor type 8 [KO:K04183]
128067871  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128068641  FADD; FAS-associated death domain protein [KO:K02373]
128064775  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
128047923  BID; BH3-interacting domain death agonist [KO:K04726]
128064207  BAX; apoptosis regulator BAX [KO:K02159]
128056082  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
128069489  cytochrome c 2 [KO:K08738]
128046227  cytochrome c [KO:K08738]
128053843  cytochrome c-like [KO:K08738]
128053924  cytochrome c [KO:K08738]
128054019  cytochrome c-like [KO:K08738]
128061241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128047668  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128063092  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
128055475  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128069947  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128066643  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128068546  RELA; transcription factor p65 [KO:K04735]
128049822  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128047322  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128046639  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
128057539  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
128058399  E2F1; transcription factor E2F1 [KO:K17454]
128043619  E2F2; transcription factor E2F2 [KO:K09389]
128056580  E2F3; transcription factor E2F3 [KO:K06620]
128050979  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
128055236  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
128055280  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
128055281  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
128055305  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
128053263  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
128050899  intercellular adhesion molecule 1 [KO:K06490]
128051541  LOW QUALITY PROTEIN: intercellular adhesion molecule 1-like [KO:K06490]
128052556  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
128055284  MHC class I polypeptide-related sequence B-like [KO:K07985]
128051488  UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
128058481  ubiquitin-like [KO:K02927]
128056114  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
128063348  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
128044485  ubiquitin-40S ribosomal protein S27a [KO:K02977]
128046640  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
128067953  LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
128065532  UBB; polyubiquitin-B [KO:K04551]
128062305  UBC; polyubiquitin-C isoform X1 [KO:K08770]
128065289  BECN1; beclin-1 [KO:K08334]
128061248  BECN2; beclin-2 [KO:K08334]
128054114  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
128067387  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
128046629  ATG3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
128062974  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
128058435  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
128061788  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
128061341  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
128068195  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
128047979  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
128050433  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
128054091  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
128068668  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
128048580  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
128046927  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128047937  KRAS; GTPase KRas [KO:K07827]
128044537  NRAS; GTPase NRas [KO:K07828]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128053931  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
128044447  JUN; transcription factor Jun [KO:K04448]
128053951  FOS; protein c-Fos [KO:K04379]
128046735  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
128065234  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
128065366  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128058020  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128051495  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128047244  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128049619  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
128044611  cell surface glycoprotein CD200 receptor 1 [KO:K21668]
128052468  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
128052376  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
128058174  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128058279  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
128059059  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
128064467  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
128050697  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
128063111  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
128058189  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128056684  CALM2; calmodulin-2 [KO:K02183]
128063810  CALM3; calmodulin-3 [KO:K02183]
128058230  calmodulin-like [KO:K02183]
128053757  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
128054267  CALM1; calmodulin-1 [KO:K02183]
128061269  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128067290  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128058335  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
128064208  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128054080  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
128049958  CXCL8; interleukin-8 [KO:K10030]
128061601  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
128049546  growth-regulated alpha protein [KO:K05505]
128049610  growth-regulated protein homolog gamma-like [KO:K05505]
128049611  growth-regulated alpha protein-like [KO:K05505]
128044647  RCAN1; calcipressin-1 [KO:K17901]
128062082  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128068156  ANGPT2; angiopoietin-2 [KO:K05466]
128066072  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
128052316  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
128065049  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128058237  CTNNB1; catenin beta-1 [KO:K02105]
128050871  TCF7; transcription factor 7 [KO:K02620]
128056483  TCF7L1; transcription factor 7-like 1 [KO:K04490]
128067999  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
128049642  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
128071103  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128061475  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
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Related
pathway
btax04010  MAPK signaling pathway
btax04064  NF-kappa B signaling pathway
btax04110  Cell cycle
btax04115  p53 signaling pathway
btax04140  Autophagy - animal
btax04144  Endocytosis
btax04151  PI3K-Akt signaling pathway
btax04210  Apoptosis
btax04310  Wnt signaling pathway
btax04610  Complement and coagulation cascades
btax04620  Toll-like receptor signaling pathway
btax04630  JAK-STAT signaling pathway
btax04650  Natural killer cell mediated cytotoxicity
btax04668  TNF signaling pathway
KO pathway
ko05167   
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