KEGG   PATHWAY: ccad05162
Entry
ccad05162                   Pathway                                
Name
Measles - Cervus canadensis (wapiti)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
ccad05162  Measles
ccad05162

Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122452312  LOW QUALITY PROTEIN: membrane cofactor protein-like [KO:K04007]
122452313  uncharacterized protein LOC122452313 [KO:K04007]
122452377  membrane cofactor protein-like [KO:K04007]
122452376  membrane cofactor protein-like isoform X1 [KO:K04007]
122451854  CD46; membrane cofactor protein isoform X1 [KO:K04007]
122449484  moesin-like [KO:K05763]
122434488  MSN; moesin [KO:K05763]
122430798  SLAMF1; signaling lymphocytic activation molecule [KO:K06536]
122439296  CD209; CD209 antigen [KO:K06563]
122452766  antiviral innate immune response receptor RIG-I-like [KO:K12646] [EC:5.6.2.6]
122453331  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
122453719  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
122448857  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
122454978  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
122451810  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
122427358  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
122421010  IRF3; interferon regulatory factor 3 [KO:K05411]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122420247  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
122455294  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122435292  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
122425090  TLR9; toll-like receptor 9 isoform X1 [KO:K10161]
122424834  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122434303  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122427504  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122430585  IRF7; interferon regulatory factor 7 [KO:K09447]
122452950  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
122453310  interferon alpha-1-like [KO:K05414]
122453141  interferon alpha-1-like [KO:K05414]
122452999  interferon alpha-1-like [KO:K05414]
122453000  interferon alpha-1-like [KO:K05414]
122453001  interferon alpha-1 [KO:K05414]
122452998  interferon alpha-1-like [KO:K05414]
122453350  interferon alpha-1-like [KO:K05414]
122453394  interferon beta-2-like [KO:K05415]
122453400  interferon beta-2-like [KO:K05415]
122453398  interferon beta-2 [KO:K05415]
122453396  interferon beta-2-like [KO:K05415]
122453397  interferon beta-2-like [KO:K05415]
122453395  interferon beta-2-like [KO:K05415]
122451361  TLR2; toll-like receptor 2 [KO:K10159]
122431924  TLR4; toll-like receptor 4 [KO:K10160]
122449806  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122447941  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
122420536  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
122429545  CSNK2B; casein kinase II subunit beta [KO:K03115]
122434091  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
122422588  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122433842  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122440572  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122428339  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122446321  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122436906  JUN; transcription factor AP-1 [KO:K04448]
122443873  FOS; proto-oncogene C-Fos [KO:K04379]
122442617  IL1A; interleukin-1 alpha [KO:K04383]
122441784  IL1B; interleukin-1 beta [KO:K04519]
122438196  IL6; interleukin-6 [KO:K05405]
122444988  IL12A; interleukin-12 subunit alpha [KO:K05406]
122439617  IL12B; interleukin-12 subunit beta [KO:K05425]
122428739  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
122428743  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
122439996  RACK1; receptor of activated protein C kinase 1 [KO:K14753]
122436869  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122440425  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
122426277  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
122427313  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
122443169  IRF9; interferon regulatory factor 9 [KO:K04693]
122422848  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
122422854  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
122422844  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
122422833  2'-5'-oligoadenylate synthase 2-like isoform X1 [KO:K14216] [EC:2.7.7.84]
122432929  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
122445359  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
122445360  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
122432775  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
122441567  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
122441770  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122443375  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
122435095  RAB9A; ras-related protein Rab-9A [KO:K07899]
122435467  RAB9B; ras-related protein Rab-9B [KO:K07900]
122450003  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
122450010  heat shock cognate 71 kDa protein-like [KO:K03283]
122423465  heat shock cognate 71 kDa protein-like [KO:K03283]
122430152  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
122428193  heat shock cognate 71 kDa protein [KO:K03283]
122430141  heat shock 70 kDa protein 1B [KO:K03283]
122430140  heat shock 70 kDa protein 1B-like [KO:K03283]
122430139  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
122441331  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 3 subunit H-like [KO:K03247]
122450888  EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
122440684  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
122443773  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
122428092  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
122445826  TP53; cellular tumor antigen P53 [KO:K04451]
122452389  TP73; tumor protein P73 [KO:K10148]
122421529  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
122452409  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122446181  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122421734  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
122431085  FADD; FAS-associated death domain protein [KO:K02373]
122426570  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122423034  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
122421035  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
122430151  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
122425862  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122448845  BCL2L1; bcl-2-like protein 1 [KO:K04570]
122449331  bcl-2-like protein 1 [KO:K04570]
122441342  bcl-2-like protein 1 [KO:K04570]
122430652  BAD; bcl2-associated agonist of cell death [KO:K02158]
122438479  cytochrome c [KO:K08738]
122440592  cytochrome c [KO:K08738]
122432475  cytochrome c-like [KO:K08738]
122434040  cytochrome c [KO:K08738]
122435448  cytochrome c [KO:K08738]
122443337  cytochrome c-like [KO:K08738]
122453615  cytochrome c [KO:K08738]
122444772  cytochrome c-like [KO:K08738]
122454513  cytochrome c-like [KO:K08738]
122436938  cytochrome c-like [KO:K08738]
122423286  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122452241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122432443  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122423697  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122430666  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
122424006  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
122429373  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122421575  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122450896  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
122427215  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122438094  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122427513  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122444227  uncharacterized protein LOC122444227 [KO:K10784]
122450232  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
122450228  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
122450336  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
122426779  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
122453281  IL2; interleukin-2 [KO:K05429]
122448159  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
122423665  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
122423666  interleukin-2 receptor subunit beta-like [KO:K05069]
122434652  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
122440740  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122454626  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122437038  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122445271  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122428853  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122445589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122440727  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
122441604  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
122441616  signal transducer and activator of transcription 5A [KO:K11223]
122441627  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
122430161  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
ccad04110  Cell cycle
ccad04115  p53 signaling pathway
ccad04120  Ubiquitin mediated proteolysis
ccad04210  Apoptosis
ccad04620  Toll-like receptor signaling pathway
ccad04622  RIG-I-like receptor signaling pathway
ccad04630  JAK-STAT signaling pathway
ccad04658  Th1 and Th2 cell differentiation
ccad04660  T cell receptor signaling pathway
KO pathway
ko05162   
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