KEGG   PATHWAY: cfa04510
Entry
cfa04510                    Pathway                                
Name
Focal adhesion - Canis lupus familiaris (dog)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cfa04510  Focal adhesion
cfa04510

Other DBs
GO: 0005925
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
403651  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
403824  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
403826  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
403841  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
403840  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
403466  COL4A5; collagen alpha-5(IV) chain precursor [KO:K06237]
403843  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
403496  COL4A1; collagen alpha-1(IV) chain isoform X3 [KO:K06237]
403842  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
403582  COL6A3; collagen alpha-3(VI) chain precursor [KO:K06238]
610649  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
610614  collagen alpha-4(VI) chain-like isoform X4 [KO:K06238]
100856491  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
403668  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
485659  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
481873  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
607609  COL9A2; collagen alpha-2(IX) chain precursor [KO:K08131]
612430  COL9A3; collagen alpha-3(IX) chain precursor [KO:K08131]
100683420  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102156629  LAMA1; laminin subunit alpha-1 [KO:K05637]
480173  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
442954  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
475034  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 isoform X1 [KO:K06241]
475882  LAMB1; laminin subunit beta-1 [KO:K05636]
476626  LAMB2; laminin subunit beta-2 isoform X5 [KO:K06243]
442953  LAMB3; laminin subunit beta-3 [KO:K06244]
483260  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
480034  LAMC1; laminin subunit gamma-1 [KO:K05635]
442939  LAMC2; laminin subunit gamma-2 precursor [KO:K06246]
491290  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
609296  CHAD; chondroadherin [KO:K06248]
483273  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
487486  THBS1; thrombospondin-1 [KO:K16857]
610359  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
484087  THBS2; thrombospondin-2 precursor [KO:K04659]
488930  THBS4; thrombospondin-4 [KO:K04659]
476665  COMP; cartilage oligomeric matrix protein [KO:K04659]
403845  FN1; fibronectin [KO:K05717]
478471  SPP1; osteopontin isoform X2 [KO:K06250]
480621  VTN; vitronectin [KO:K06251]
490335  TNN; tenascin-N isoform X6 [KO:K06252]
490334  TNR; tenascin-R [KO:K06252]
481689  TNC; tenascin precursor [KO:K06252]
100682877  TNXB; tenascin-X isoform X16 [KO:K06252]
399544  VWF; von Willebrand factor precursor [KO:K03900]
609146  IBSP; bone sialoprotein 2 [KO:K06253]
489210  ITGA1; integrin alpha-1 [KO:K06480]
489208  ITGA2; integrin alpha-2 [KO:K06481]
403789  ITGA2B; integrin alpha-IIb [KO:K06476]
491074  ITGA3; integrin alpha-3 [KO:K06482]
488429  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
486493  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100856563  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
481097  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
487119  ITGA8; integrin alpha-8 [KO:K06584]
477021  ITGA9; integrin alpha-9 [KO:K06585]
608287  ITGA10; integrin alpha-10 isoform X5 [KO:K06586]
478353  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
488437  ITGAV; integrin alpha-V isoform X5 [KO:K06487]
477956  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
403788  ITGB3; integrin beta-3 precursor [KO:K06493]
483318  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
608977  ITGB5; integrin beta-5 [KO:K06588]
488368  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
477598  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
475253  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
490010  EMP2; epithelial membrane protein 2 isoform X5 [KO:K26256]
491597  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
442986  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
479460  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
482666  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
403657  EGF; pro-epidermal growth factor precursor [KO:K04357]
610255  IGF1; insulin-like growth factor I precursor [KO:K05459]
403802  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
476036  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100855780  PGF; placenta growth factor isoform X3 [KO:K16859]
482932  VEGFC; vascular endothelial growth factor C [KO:K05449]
491749  VEGFD; vascular endothelial growth factor D isoform X2 [KO:K05449]
403441  HGF; hepatocyte growth factor precursor [KO:K05460]
442860  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
442985  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
442951  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
482154  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
404306  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
403727  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
481464  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
403438  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
403883  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
486676  EMP1; epithelial membrane protein 1 [KO:K26255]
485864  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
403543  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
490642  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
403954  RHOA; transforming protein RhoA [KO:K04513]
100684883  DIAPH1; protein diaphanous homolog 1 isoform X2 [KO:K05740]
480181  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
482970  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
403614  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
479135  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
100683291  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
485856  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
608177  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
480193  MYL12B; myosin regulatory light chain 12B [KO:K12757]
607207  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
479772  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
403557  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
403558  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
403609  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
475411  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
490230  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X12 [KO:K12329]
100683226  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
488012  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
475345  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
488190  myosin light chain kinase family member 4 isoform X18 [KO:K00907] [EC:2.7.11.18]
477187  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
476331  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3 [KO:K00889] [EC:2.7.1.68]
485054  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
475846  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
403580  ACTB; actin, cytoplasmic 1 [KO:K05692]
475923  ACTG1; actin, cytoplasmic 2 [KO:K05692]
488774  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
480118  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
480369  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
484526  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
478331  TLN2; talin-2 isoform X1 [KO:K06271]
100856393  TLN1; talin-1 isoform X4 [KO:K06271]
481084  FLNA; filamin-A isoform X1 [KO:K04437]
484713  FLNB; filamin-B isoform X1 [KO:K27392]
486299  PXN; paxillin isoform X2 [KO:K05760]
476836  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
482736  ZYX; zyxin isoform X1 [KO:K06273]
403936  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
479252  VCL; vinculin isoform X14 [KO:K05700]
481214  PARVG; gamma-parvin isoform X1 [KO:K06275]
481215  PARVB; beta-parvin isoform X2 [KO:K06275]
476859  PARVA; alpha-parvin isoform X2 [KO:K06275]
479875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
442964  AKT3; RAC-gamma serine/threonine-protein kinase isoform X8 [KO:K04456] [EC:2.7.11.1]
449021  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
490878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
478575  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
477032  CTNNB1; catenin beta-1 [KO:K02105]
490904  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
489968  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100855828  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
475108  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100856339  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
403832  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
608060  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
485016  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
479921  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
481271  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
106559217  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
607885  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
612814  PAK2; serine/threonine-protein kinase PAK 2 isoform X2 [KO:K04410] [EC:2.7.11.1]
492067  PAK3; serine/threonine-protein kinase PAK 3 isoform X20 [KO:K05733] [EC:2.7.11.1]
484513  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
485772  PAK5; serine/threonine-protein kinase PAK 5 isoform X2 [KO:K05736] [EC:2.7.11.1]
100856038  PAK6; serine/threonine-protein kinase PAK 6 isoform X9 [KO:K05735] [EC:2.7.11.1]
119863888  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119866928  cell division control protein 42 homolog [KO:K04393]
479648  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X9 [KO:K05726]
608125  CRKL; crk-like protein isoform X2 [KO:K04438]
100684309  CRK; adapter molecule crk isoform X8 [KO:K04438]
486934  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
491286  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
483225  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
608981  RAP1B; ras-related protein Rap-1b [KO:K07836]
477746  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
478464  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
474652  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
609429  JUN; transcription factor AP-1 [KO:K04448]
475526  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
403980  CAV1; caveolin-1 [KO:K06278]
475294  CAV2; caveolin-2 [KO:K12958]
484671  CAV3; caveolin-3 [KO:K12959]
475032  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
490439  SHC1; SHC-transforming protein 1 [KO:K06279]
611955  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
476352  SHC3; SHC-transforming protein 3 [KO:K17448]
487546  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
483312  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
490682  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
403735  HRAS; GTPase HRas isoform 1 [KO:K02833]
484648  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
478347  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
491860  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
611782  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
608847  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
479464  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
489433  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
442989  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
483763  BAD; bcl2-associated agonist of cell death [KO:K02158]
403416  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
cfa04010  MAPK signaling pathway
cfa04060  Cytokine-cytokine receptor interaction
cfa04070  Phosphatidylinositol signaling system
cfa04110  Cell cycle
cfa04151  PI3K-Akt signaling pathway
cfa04310  Wnt signaling pathway
cfa04512  ECM-receptor interaction
cfa04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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