KEGG   PATHWAY: chx05165
Entry
chx05165                    Pathway                                
Name
Human papillomavirus infection - Capra hircus (goat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
chx05165  Human papillomavirus infection
chx05165

Organism
Capra hircus (goat) [GN:chx]
Gene
102180014  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102182009  WNT2B; protein Wnt-2b [KO:K00182]
102180281  WNT2; protein Wnt-2 [KO:K00182]
102184049  WNT3A; protein Wnt-3a [KO:K00312]
102169703  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102187819  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102176310  WNT5B; protein Wnt-5b [KO:K00444]
102170921  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
108637658  WNT6; protein Wnt-6 [KO:K00445]
102176768  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
102171665  WNT7A; protein Wnt-7a [KO:K00572]
102184053  WNT8A; protein Wnt-8a isoform X2 [KO:K00714]
102176193  WNT8B; protein Wnt-8b [KO:K00714]
102184896  WNT9A; protein Wnt-9a [KO:K01064]
102169419  WNT9B; protein Wnt-9b [KO:K01064]
102169259  WNT10B; protein Wnt-10b [KO:K01357]
102177945  WNT10A; protein Wnt-10a [KO:K01357]
102175498  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102191205  WNT16; protein Wnt-16 [KO:K01558]
102172948  FZD7; frizzled-7 [KO:K02432]
102183205  FZD1; frizzled-1 [KO:K02432]
102188440  FZD2; frizzled-2 [KO:K02235]
102178446  FZD3; frizzled-3 [KO:K02329]
102184122  FZD4; frizzled-4 [KO:K02354]
106502750  FZD8; frizzled-8 [KO:K02375]
102175724  FZD5; frizzled-5 [KO:K02375]
102170617  FZD6; frizzled-6 [KO:K02376]
102174961  FZD10; frizzled-10 [KO:K02842]
102180448  FZD9; frizzled-9 [KO:K02842]
102182444  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102189698  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102188083  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
102176363  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102170375  AXIN1; axin-1 isoform X1 [KO:K02157]
102180348  AXIN2; axin-2 isoform X1 [KO:K04385]
102184724  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102177435  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
102191742  CTNNB1; catenin beta-1 [KO:K02105]
102184414  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
108634926  casein kinase I [KO:K08957] [EC:2.7.11.1]
102183940  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
102181496  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
102187716  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
102173736  TCF7; transcription factor 7 isoform X1 [KO:K02620]
102187776  TCF7L1; transcription factor 7-like 1 [KO:K04490]
102180102  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
102189626  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
102182757  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
102170774  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102171742  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102183809  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102171811  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
102187824  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102187383  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
102184480  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
102178670  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9 [KO:K05631]
102185891  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102185098  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
102174045  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102187092  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102185594  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102179047  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102186420  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102188638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102182705  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
102178485  DLG1; disks large homolog 1 isoform X3 [KO:K12076]
102169162  DLG2; disks large homolog 2 isoform X12 [KO:K12075]
102173541  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
102173503  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
102181627  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
102189115  CRB3; protein crumbs homolog 3 [KO:K06090]
102188460  PATJ; inaD-like protein isoform X1 [KO:K06092]
102168546  MPP5; MAGUK p55 subfamily member 5 isoform X3 [KO:K06091]
102191119  VWF; von Willebrand factor [KO:K03900]
100860971  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
102179675  THBS4; thrombospondin-4 [KO:K04659]
102179674  THBS2; thrombospondin-2 [KO:K04659]
102190652  THBS3; thrombospondin-3 [KO:K04659]
102190117  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
102182645  FN1; fibronectin isoform X1 [KO:K05717]
100860828  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
108634775  basic proline-rich protein-like [KO:K06236]
100860940  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100860743  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102176677  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102176947  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
108633195  collagen alpha-6(IV) chain-like [KO:K06237]
102171347  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102171079  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102190083  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102190364  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102178669  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
102191085  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102191378  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102178401  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102169643  COL6A3; collagen alpha-3(VI) chain isoform X5 [KO:K06238]
102185378  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
102188580  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102186825  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102187050  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102176003  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
102171801  LAMA5; laminin subunit alpha-5 [KO:K06240]
102190835  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102177440  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102176661  LAMB1; laminin subunit beta-1 [KO:K05636]
102183372  laminin subunit beta-2 isoform X1 [KO:K06243]
102179246  laminin subunit beta-2 [KO:K06243]
102168376  LAMB3; laminin subunit beta-3 [KO:K06244]
102174902  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
102170256  LAMC1; laminin subunit gamma-1 [KO:K05635]
102170540  LAMC2; laminin subunit gamma-2 [KO:K06246]
102184914  LAMC3; laminin subunit gamma-3 [KO:K06247]
102176727  CHAD; chondroadherin [KO:K06248]
102172966  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100860805  SPP1; osteopontin precursor [KO:K06250]
100861216  VTN; vitronectin [KO:K06251]
102181229  TNN; tenascin-N [KO:K06252]
102181525  TNR; tenascin-R [KO:K06252]
102174446  TNXB; tenascin-X isoform X1 [KO:K06252]
102179198  TNC; tenascin isoform X1 [KO:K06252]
102175843  IBSP; bone sialoprotein 2 [KO:K06253]
102172761  ITGA1; integrin alpha-1 [KO:K06480]
102172198  ITGA2; integrin alpha-2 [KO:K06481]
102183451  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102185499  ITGA3; integrin alpha-3 [KO:K06482]
102183190  ITGA4; integrin alpha-4 [KO:K06483]
102176587  ITGA5; integrin alpha-5 [KO:K06484]
102186530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102169839  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102181695  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102174073  ITGA9; integrin alpha-9 [KO:K06585]
102185415  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102171074  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102187813  ITGAV; integrin alpha-V precursor [KO:K06487]
102178060  ITGB1; integrin beta-1 precursor [KO:K05719]
102169417  ITGB3; integrin beta-3 [KO:K06493]
102191175  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102173608  ITGB5; integrin beta-5 [KO:K06588]
102188539  ITGB6; integrin beta-6 precursor [KO:K06589]
102180190  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
102191301  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102178097  PXN; paxillin isoform X1 [KO:K05760]
100861232  TNF; tumor necrosis factor [KO:K03156]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102180248  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102178753  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102180451  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
102170760  FADD; FAS-associated death domain protein [KO:K02373]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
106503247  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
102175016  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108637886  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102182013  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102170070  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102182533  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102181952  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102170971  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
102188298  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102177705  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
102191740  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102182916  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
102182878  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
102185489  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102169526  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
100861365  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102171557  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
102178739  TSC1; hamartin [KO:K07206]
100860943  TSC2; tuberin [KO:K07207]
100861308  RHEB; GTP-binding protein Rheb [KO:K07208]
100860902  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100861234  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100861297  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102169319  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
102182675  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102170562  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102184426  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102184915  FOXO1; forkhead box protein O1 [KO:K07201]
102175277  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102179898  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102169650  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102180657  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102190470  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102171306  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102180182  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102185672  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102184185  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100860751  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102183886  RB1; retinoblastoma-associated protein [KO:K06618]
102179111  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
102181890  RBL2; retinoblastoma-like protein 2 [KO:K16332]
102190237  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
102173018  E2F1; transcription factor E2F1 [KO:K17454]
102176051  CCNA1; cyclin-A1 [KO:K06627]
102190390  CCNA2; cyclin-A2 [KO:K06627]
102190803  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102178489  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100860957  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102174096  RELA; transcription factor p65 [KO:K04735]
102173163  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
102189865  NFX1; transcriptional repressor NF-X1 isoform X4 [KO:K12236]
102177165  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102187544  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102174819  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
102188583  IRF1; interferon regulatory factor 1 [KO:K09444]
102173392  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
102176044  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
102182309  TBP; TATA-box-binding protein [KO:K03120]
102172138  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102180584  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102188814  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
102181202  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
108633459  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
108633460  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102183314  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102176782  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102170045  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102168905  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102169753  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102185917  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102181347  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
108633505  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102175817  patr class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102171703  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
102182019  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
102186053  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102191135  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102185090  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102182700  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
102171171  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102185906  V-type proton ATPase subunit D-like [KO:K02149]
102169296  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102174547  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102169483  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X2 [KO:K02150]
102176937  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102177162  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102173216  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102187358  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102181518  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102179797  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102186995  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102186280  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102171404  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102172556  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102178477  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
102189904  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
102170666  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
108633881  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102191393  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
108635054  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
106502862  V-type proton ATPase subunit S1 [KO:K03662]
106502173  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102172767  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102170356  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102185660  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102184154  SOS2; son of sevenless homolog 2 [KO:K03099]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100860905  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102188631  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
102188874  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
108633189  neuroendocrine secretory protein 55 [KO:K04632]
102173379  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102168790  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
102186065  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102180221  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102174829  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102183745  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102183893  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102170199  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102190378  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102171113  UBR4; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
102183453  TUBG1; tubulin gamma-1 chain [KO:K10389]
102188627  tubulin gamma-2 chain [KO:K10389]
102178731  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102191552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102175057  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102182846  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102188492  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
102189170  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102190301  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102190231  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102171521  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
102175976  OASL; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
102188635  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
108636422  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
102169982  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
102189768  JAG1; protein jagged-1 [KO:K06052]
102172636  NOTCH1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
102177020  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
102189202  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
102173344  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
102182879  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
102178708  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
102178013  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
102169449  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
102191545  MAML3; mastermind-like protein 3 [KO:K06061]
102184738  MAML2; LOW QUALITY PROTEIN: mastermind-like protein 2 [KO:K06061]
102181584  MAML1; mastermind-like protein 1 [KO:K06061]
102186030  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
102185075  RBPJ; recombining binding protein suppressor of hairless isoform X3 [KO:K06053]
102177474  HES1; transcription factor HES-1 [KO:K06054]
102178693  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
106502979  HES2; transcription factor HES-2 isoform X1 [KO:K09087]
106503241  HES7; transcription factor HES-7 [KO:K09087]
108637738  HES3; transcription factor HES-3 [KO:K09088]
106502961  HES4; transcription factor HES-4 [KO:K09089]
108637781  HES5; transcription factor HES-5 [KO:K06055]
102191579  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
102185747  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
102178088  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Rev Med Virol 19:97-113 (2009)
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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The molecular biology of cervical cancer.
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Reference
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Sci Rep 5:13446 (2015)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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Reference
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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The evolving field of human papillomavirus receptor research: a review of binding and entry.
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Related
pathway
chx04064  NF-kappa B signaling pathway
chx04110  Cell cycle
chx04115  p53 signaling pathway
chx04150  mTOR signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04210  Apoptosis
chx04310  Wnt signaling pathway
chx04330  Notch signaling pathway
chx04510  Focal adhesion
chx04520  Adherens junction
chx04530  Tight junction
chx04612  Antigen processing and presentation
chx04620  Toll-like receptor signaling pathway
chx04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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