KEGG   PATHWAY: dpub04010
Entry
dpub04010                   Pathway                                
Name
MAPK signaling pathway - Dryobates pubescens (Downy woodpecker)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dpub04010  MAPK signaling pathway
dpub04010

Other DBs
GO: 0000165
Organism
Dryobates pubescens (Downy woodpecker) [GN:dpub]
Gene
104296985  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
104299582  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104300406  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104301595  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104310118  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104297464  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
104302085  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104309266  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104299801  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104300409  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
104308795  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
104310231  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104296374  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
104308270  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
104302189  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104302115  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
104306917  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
104302187  CACNG4; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104302186  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104300085  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104302207  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104300281  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104297114  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104307985  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104297681  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104307773  PPP3CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104304311  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104300961  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104309374  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104306848  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104299959  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
104303880  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104302677  NF1; neurofibromin [KO:K08052]
104310160  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104300640  RASA2; ras GTPase-activating protein 2 [KO:K08053]
104296422  RAP1A; ras-related protein Rap-1A [KO:K04353]
104305542  RAP1B; ras-related protein Rap-1b [KO:K07836]
104304147  EGF; pro-epidermal growth factor [KO:K04357]
104310146  TGFA; protransforming growth factor alpha [KO:K08774]
104297120  EREG; proepiregulin [KO:K09784]
104297135  AREG; amphiregulin [KO:K09782]
104301868  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104296220  FGF2; fibroblast growth factor 2 [KO:K18497]
104297336  FGF7; fibroblast growth factor 7 [KO:K04358]
104297559  FGF3; fibroblast growth factor 3 [KO:K04358]
104303366  FGF9; fibroblast growth factor 9 [KO:K04358]
104304164  FGF20; fibroblast growth factor 20 [KO:K04358]
104309106  FGF10; fibroblast growth factor 10 [KO:K04358]
104304951  FGF18; fibroblast growth factor 18 [KO:K04358]
104309516  FGF17; fibroblast growth factor 17 [KO:K04358]
104300157  FGF16; fibroblast growth factor 16 [KO:K04358]
104300663  FGF22; fibroblast growth factor 22 [KO:K04358]
104301120  FGF6; fibroblast growth factor 6 [KO:K04358]
104297130  FGF5; fibroblast growth factor 5 [KO:K04358]
104307087  FGF8; fibroblast growth factor 8 [KO:K04358]
104297560  fibroblast growth factor 4-like [KO:K22603]
104301121  FGF23; fibroblast growth factor 23 [KO:K22428]
104296292  NGF; beta-nerve growth factor [KO:K02582]
104300997  BDNF; brain-derived neurotrophic factor [KO:K04355]
104306298  NTF3; neurotrophin-3 [KO:K04356]
104305807  INS; insulin [KO:K04526]
104296561  IGF1; insulin-like growth factor I [KO:K05459]
104305809  IGF2; insulin-like growth factor II [KO:K13769]
104307709  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104302015  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104298789  PDGFC; platelet-derived growth factor C [KO:K05450]
104296914  PDGFD; platelet-derived growth factor D [KO:K05450]
104301078  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104299196  KITLG; kit ligand [KO:K05461]
104299964  VEGFA; vascular endothelial growth factor A [KO:K05448]
104310139  FIGF; vascular endothelial growth factor D [KO:K05449]
104296532  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
104299860  HGF; hepatocyte growth factor [KO:K05460]
104298147  ANGPT1; angiopoietin-1 [KO:K05465]
104303540  ANGPT2; angiopoietin-2 [KO:K05466]
104301429  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
104299055  EFNA2; ephrin-A2 [KO:K05462]
104300189  EFNA5; ephrin-A5 [KO:K05462]
104310263  EFNA4; ephrin-A4 [KO:K05462]
104310264  EFNA3; ephrin-A3 [KO:K05462]
104310265  EFNA1; ephrin-A1 [KO:K05462]
104303129  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104309480  neurturin-like [KO:K25414]
104301554  ARTN; artemin [KO:K25415]
104298303  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104302703  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
104301278  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
104309126  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
104303599  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104303924  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104299911  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104306765  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
104300798  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
104298885  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104299132  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104309991  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104296245  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104299165  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104306117  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104300147  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104306096  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104309972  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104299166  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2-like [KO:K05098] [EC:2.7.10.1]
104309184  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104304183  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104298836  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104297925  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104299371  SOS2; son of sevenless homolog 2 [KO:K03099]
104301333  SOS1; son of sevenless homolog 1 [KO:K03099]
104305653  GTPase HRas-like [KO:K02833]
104305177  KRAS; GTPase KRas [KO:K07827]
104296307  NRAS; GTPase NRas [KO:K07828]
104304428  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104309761  MRAS; ras-related protein M-Ras [KO:K07831]
104302506  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104301896  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104303271  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104303243  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104305249  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104309647  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104307915  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104308361  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
104307507  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104300481  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
104305495  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104297002  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104302010  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104304778  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
104302934  MYC; myc proto-oncogene protein [KO:K04377]
104300908  SRF; serum response factor [KO:K04378]
104308225  FOS; proto-oncogene c-Fos [KO:K04379]
104309233  MAPT; microtubule-associated protein tau [KO:K04380]
104307397  STMN1; stathmin [KO:K04381]
104298854  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104298855  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298856  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298867  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298868  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298869  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298870  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298871  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104298874  PLA2G4B; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104309400  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104305921  interleukin-1 beta-like [KO:K04519]
104299873  TGFB2; transforming growth factor beta-2 [KO:K13376]
104308192  TGFB3; transforming growth factor beta-3 [KO:K13377]
104305665  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104310045  interleukin-1 receptor type 1-like [KO:K04386]
104300719  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104299593  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104298273  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104303745  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104298200  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104297781  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104299652  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104302041  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104297886  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104305486  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104299009  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104309548  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104300175  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104298988  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104299101  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104304786  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104301139  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104302014  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104297166  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104301072  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
104310022  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104301201  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
104306026  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104299286  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104308751  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104298132  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
104298496  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104306360  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104309758  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104298979  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
104309224  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104300341  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104307043  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
104305531  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104305754  mitogen-activated protein kinase kinase kinase MLT [KO:K04424] [EC:2.7.11.25]
104310010  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104297616  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104307727  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104302779  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104308446  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
104306015  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104296953  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104297856  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104300582  MAPK8IP1; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104300267  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104302823  CRK; adapter molecule crk [KO:K04438]
104309619  CRKL; crk-like protein [KO:K04438]
104297715  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104309327  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
104309863  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104297424  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104297425  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104302149  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104302150  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104308421  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104297262  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104300390  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104304126  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104308747  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
104299023  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104301752  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
104305746  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104299810  protein max-like [KO:K04453]
104299886  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
104304037  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104304791  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104303169  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104309456  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104299776  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104309260  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104303946  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104307187  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104303185  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104298653  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104304512  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104305441  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104305174  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104299867  DUSP10; LOW QUALITY PROTEIN: dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104300563  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104303417  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
104302629  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104301922  MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104303268  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104300039  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104302590  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104301261  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104302639  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104307765  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104297767  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
dpub04070  Phosphatidylinositol signaling system
dpub04110  Cell cycle
dpub04115  p53 signaling pathway
dpub04210  Apoptosis
dpub04310  Wnt signaling pathway
KO pathway
ko04010   
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