KEGG   PATHWAY: mjv05165
Entry
mjv05165                    Pathway                                
Name
Human papillomavirus infection - Manis javanica (Malayan pangolin)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mjv05165  Human papillomavirus infection
mjv05165

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383443  WNT1; proto-oncogene Wnt-1 [KO:K03209]
108393959  WNT2; protein Wnt-2 [KO:K00182]
108398947  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
108388938  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
108398816  WNT3A; protein Wnt-3a [KO:K00312]
108391532  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
108397016  WNT5B; protein Wnt-5b isoform X3 [KO:K00444]
108403168  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
108390505  WNT6; protein Wnt-6 [KO:K00445]
108404182  WNT7A; protein Wnt-7a isoform X2 [KO:K00572]
108410319  WNT8A; protein Wnt-8a [KO:K00714]
108409584  WNT8B; protein Wnt-8b [KO:K00714]
108398815  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
108388856  WNT9B; protein Wnt-9b [KO:K01064]
108390506  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
108383428  WNT10B; protein Wnt-10b [KO:K01357]
108405770  WNT11; protein Wnt-11 [KO:K01384]
108406833  WNT16; protein Wnt-16 [KO:K01558]
108386027  FZD7; frizzled-7 [KO:K02432]
108384294  frizzled-1 [KO:K02432]
118972654  frizzled-1 [KO:K02432]
108403667  FZD2; frizzled-2 [KO:K02235]
108406043  FZD3; frizzled-3 [KO:K02329]
108395112  FZD4; frizzled-4 [KO:K02354]
108395847  FZD5; frizzled-5 [KO:K02375]
108397709  FZD8; frizzled-8 [KO:K02375]
108386613  FZD6; frizzled-6 isoform X3 [KO:K02376]
108397276  FZD9; frizzled-9 [KO:K02842]
108399714  FZD10; frizzled-10 [KO:K02842]
108395276  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
108401217  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118973512  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
118974014  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
108408942  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
108389003  GSK3B; glycogen synthase kinase-3 beta isoform X5 [KO:K03083] [EC:2.7.11.26]
108408106  AXIN1; axin-1 isoform X1 [KO:K02157]
108392410  AXIN2; axin-2 isoform X1 [KO:K04385]
108408639  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
108404758  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
108387548  CTNNB1; catenin beta-1 [KO:K02105]
108398542  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
108394798  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
108408611  TERT; telomerase reverse transcriptase isoform X3 [KO:K11126] [EC:2.7.7.49]
108406081  TCF7; transcription factor 7 isoform X1 [KO:K02620]
108405898  TCF7L1; transcription factor 7-like 1 [KO:K04490]
108408173  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
108387602  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
108396408  TLR3; toll-like receptor 3 [KO:K05401]
108391396  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
108406584  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108390202  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
108399262  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108400317  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
108402531  IFNB1; interferon beta [KO:K05415]
108394315  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108395362  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108407968  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
108404266  TP53; cellular tumor antigen p53 [KO:K04451]
118974052  cellular tumor antigen p53 [KO:K04451]
108392147  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
108397450  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108395882  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118969461  partitioning defective 6 homolog beta-like [KO:K06093]
118969605  partitioning defective 6 homolog beta-like [KO:K06093]
108387488  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118973716  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
108393654  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
108386155  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108408003  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
108403637  DLG3; disks large homolog 3 isoform X4 [KO:K21098]
108400652  LLGL2; LLGL scribble cell polarity complex component 2 isoform X6 [KO:K06094]
108401070  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X4 [KO:K06094]
108406204  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
108400752  PATJ; inaD-like protein [KO:K06092]
108401154  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
108404459  VWF; von Willebrand factor [KO:K03900]
108400147  THBS1; thrombospondin-1 [KO:K16857]
108406027  cartilage oligomeric matrix protein [KO:K04659]
108407292  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
108406777  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
108390191  THBS4; thrombospondin-4 [KO:K04659]
108407058  FN1; fibronectin isoform X1 [KO:K05717]
108398405  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
108385124  COL1A1; collagen alpha-1(I) chain [KO:K06236]
108392454  COL2A1; collagen alpha-1(II) chain [KO:K19719]
108406100  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108391617  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
108397219  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
108397237  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
108401312  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108395182  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108409564  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
108406673  collagen alpha-6(VI) chain isoform X1 [KO:K06238]
108406785  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
108402426  LOW QUALITY PROTEIN: collagen alpha-5(VI) chain-like [KO:K06238]
108409560  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
108404568  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
108399163  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
108408944  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
108397227  LAMA2; laminin subunit alpha-2 [KO:K05637]
108400452  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
108399156  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
108401680  LAMA3; laminin subunit alpha-3 [KO:K06240]
108399832  LAMA4; laminin subunit alpha-4 [KO:K06241]
108404581  LAMB1; laminin subunit beta-1 [KO:K05636]
108383249  LAMB2; laminin subunit beta-2 [KO:K06243]
108392348  LAMB4; laminin subunit beta-4 [KO:K06245]
108410039  LAMC1; laminin subunit gamma-1 [KO:K05635]
108410040  LAMC2; laminin subunit gamma-2 [KO:K06246]
108408192  LAMC3; laminin subunit gamma-3 [KO:K06247]
108384403  CHAD; chondroadherin [KO:K06248]
108407456  RELN; reelin [KO:K06249] [EC:3.4.21.-]
108401269  SPP1; osteopontin isoform X1 [KO:K06250]
108396937  VTN; vitronectin [KO:K06251]
108394274  TNR; tenascin-R isoform X3 [KO:K06252]
108401015  TNC; tenascin isoform X1 [KO:K06252]
108401268  bone sialoprotein 2 [KO:K06253]
108400786  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
108386296  ITGA2; integrin alpha-2 [KO:K06481]
108410024  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108385122  ITGA3; integrin alpha-3 [KO:K06482]
108408834  ITGA4; integrin alpha-4 [KO:K06483]
108408507  ITGA5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
108405577  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108395928  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
108396731  ITGA8; integrin alpha-8 [KO:K06584]
108393230  ITGA9; integrin alpha-9 [KO:K06585]
108400389  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
108401199  ITGA11; integrin alpha-11 [KO:K06587]
108396573  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108397161  integrin beta-1 isoform X1 [KO:K05719]
118970953  integrin beta-1-like [KO:K05719]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108400639  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108410150  ITGB5; integrin beta-5 [KO:K06588]
108390684  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
108405384  ITGB7; integrin beta-7 [KO:K06590]
108391499  ITGB8; integrin beta-8 [KO:K06591]
108394624  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
108397691  PXN; paxillin isoform X1 [KO:K05760]
108397877  TNF; tumor necrosis factor [KO:K03156]
108387612  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
108390345  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
108401438  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108401442  FADD; FAS-associated death domain protein [KO:K02373]
108389793  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
108385957  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
108405988  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108406080  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118972014  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
108405702  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
108409759  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
108393544  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X5 [KO:K04354]
108388016  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
108410331  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
108406417  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
108391324  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
108402565  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
108395051  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
108396377  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
108409537  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
108389738  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
108386004  TSC1; hamartin isoform X1 [KO:K07206]
108410254  TSC2; tuberin isoform X12 [KO:K07207]
108387268  RHEB; GTP-binding protein Rheb [KO:K07208]
108390746  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108409141  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108393161  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108401175  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108402940  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108409638  FOXO1; forkhead box protein O1 [KO:K07201]
108391616  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108385913  cyclin-dependent kinase inhibitor 1 [KO:K06625]
118970122  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108403976  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108405335  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108387631  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108392535  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108385232  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
108396147  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
108395918  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108384777  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
108405977  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
108388354  RBL2; retinoblastoma-like protein 2 [KO:K16332]
108404313  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
108401113  E2F1; transcription factor E2F1 [KO:K17454]
108400099  CCNA2; cyclin-A2 isoform X2 [KO:K06627]
108404799  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
108394726  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
108397427  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108409586  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108399795  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108400819  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108391706  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108397005  RELA; transcription factor p65 isoform X1 [KO:K04735]
108394490  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108393553  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
108407680  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
108404446  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
108387610  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
108388419  IRF1; interferon regulatory factor 1 [KO:K09444]
108402561  TATA-box-binding protein [KO:K03120]
108386588  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
108394219  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
108388563  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X1 [KO:K06751]
108390694  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
108391351  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
108399725  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
108402412  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
108396238  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
108397452  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
108384241  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
108408008  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
108399473  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
108401156  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
108406402  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
108400236  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
108392168  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
108393298  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
108397882  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
108400139  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
108410098  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
108386060  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
108395291  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
108405827  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
108390361  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
108403942  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
108397575  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
108398729  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
108399814  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
108404450  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
108400816  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108398047  NRAS; GTPase NRas [KO:K07828]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108406216  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
108404752  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
108406177  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
108406179  neuroendocrine secretory protein 55-like [KO:K04632]
118970338  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108400315  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118969429  apoptosis regulator BAX [KO:K02159]
108396160  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108407563  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108406808  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
108408210  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108401935  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108385045  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108405132  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
108394566  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
108386055  tubulin gamma-1 chain [KO:K10389]
108396911  PKM; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
108397409  interferon alpha-2-like [KO:K05414]
108388277  interferon alpha-1/13-like [KO:K05414]
108409505  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108405993  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108397113  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
108400080  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
108402236  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108391263  IRF9; interferon regulatory factor 9 [KO:K04693]
108392233  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
108392413  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
108392411  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
108405696  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
108402292  JAG1; protein jagged-1 isoform X1 [KO:K06052]
108387650  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
108390794  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
108408749  NOTCH3; neurogenic locus notch homolog protein 3 isoform X2 [KO:K20995]
108393800  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
108395378  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
108392670  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
108398746  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X3 [KO:K05948] [EC:2.4.1.222]
108395246  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
108405866  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
108408545  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
108401189  MAML1; mastermind-like protein 1 [KO:K06061]
108406893  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
108384934  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
108399743  HES1; transcription factor HES-1 [KO:K06054]
108407241  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
108384674  HES2; transcription factor HES-2 isoform X1 [KO:K09087]
108409683  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
108393174  HES3; transcription factor HES-3 isoform X1 [KO:K09088]
118968620  HES5; transcription factor HES-5 [KO:K06055]
108397627  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
108393070  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
108401207  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Related
pathway
mjv04064  NF-kappa B signaling pathway
mjv04110  Cell cycle
mjv04115  p53 signaling pathway
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04310  Wnt signaling pathway
mjv04330  Notch signaling pathway
mjv04510  Focal adhesion
mjv04520  Adherens junction
mjv04530  Tight junction
mjv04612  Antigen processing and presentation
mjv04620  Toll-like receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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