KEGG   PATHWAY: mthb04014
Entry
mthb04014                   Pathway                                
Name
Ras signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04014  Ras signaling pathway
mthb04014

Other DBs
GO: 0032318
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126934085  protransforming growth factor alpha isoform X1 [KO:K08774]
126957258  LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
126954986  fibroblast growth factor 2 [KO:K18497]
126942993  fibroblast growth factor 22 [KO:K04358]
126962737  fibroblast growth factor 8 isoform X1 [KO:K04358]
126931752  fibroblast growth factor 6 [KO:K04358]
126956981  fibroblast growth factor 18 [KO:K04358]
126957199  fibroblast growth factor 10 [KO:K04358]
126946335  fibroblast growth factor 16 [KO:K04358]
126958707  fibroblast growth factor 7 [KO:K04358]
126940532  fibroblast growth factor 9 [KO:K04358]
126935967  fibroblast growth factor 3 [KO:K04358]
126935973  fibroblast growth factor 4 [KO:K04358]
126960920  fibroblast growth factor 20 [KO:K04358]
126961295  fibroblast growth factor 17 isoform X1 [KO:K04358]
126935968  fibroblast growth factor 19 [KO:K22603]
126943598  fibroblast growth factor 21 [KO:K22429]
126931744  fibroblast growth factor 23 [KO:K22428]
126930848  beta-nerve growth factor [KO:K02582]
126934686  brain-derived neurotrophic factor isoform X1 [KO:K04355]
126930453  neurotrophin-3 isoform X1 [KO:K04356]
126943596  neurotrophin-4 [KO:K12457]
126935873  insulin isoform X1 [KO:K04526]
126931779  insulin-like growth factor I isoform X1 [KO:K05459]
126935883  insulin-like growth factor II [KO:K13769]
126950578  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126963759  platelet-derived growth factor subunit B [KO:K17386]
126936264  platelet-derived growth factor D isoform X1 [KO:K05450]
126954312  platelet-derived growth factor C [KO:K05450]
126929640  macrophage colony-stimulating factor 1 [KO:K05453]
126929998  kit ligand isoform X1 [KO:K05461]
126943138  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126935608  vascular endothelial growth factor B isoform X1 [KO:K16858]
126959573  placenta growth factor isoform X1 [KO:K16859]
126955710  vascular endothelial growth factor C isoform X1 [KO:K05449]
126946911  vascular endothelial growth factor D isoform X1 [KO:K05449]
126949900  hepatocyte growth factor isoform X1 [KO:K05460]
126961624  angiopoietin-1 isoform X1 [KO:K05465]
126961064  angiopoietin-2 isoform X1 [KO:K05466]
126964222  angiopoietin-4 isoform X1 [KO:K05467]
126942796  ephrin-A2 [KO:K05462]
126957121  ephrin-A5 isoform X1 [KO:K05462]
126934418  ephrin-A4 isoform X1 [KO:K05462]
126934582  ephrin-A3 isoform X1 [KO:K05462]
126934657  ephrin-A1 [KO:K05462]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126961189  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126962662  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126955560  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126956321  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126939872  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126948042  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
126937627  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126959327  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
126954734  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126956582  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126956584  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126954735  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
126940719  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
126940714  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126956306  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
126954733  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126951204  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126937984  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
126956768  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126954977  GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
126935686  GRB2-associated-binding protein 2 [KO:K08091]
126933571  SHC-transforming protein 1 isoform X1 [KO:K06279]
126942949  SHC-transforming protein 2 [KO:K17447]
126937656  SHC-transforming protein 3 [KO:K17448]
126958692  SHC-transforming protein 4 [KO:K17449]
126931454  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126963902  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126943961  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126960104  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
126935564  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126934266  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
126942141  RAS guanyl-releasing protein 4 [KO:K12363]
126958307  uncharacterized protein LOC126958307 [KO:K10784]
126951109  LOW QUALITY PROTEIN: M1-specific T cell receptor beta chain-like [KO:K10785]
126934295  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
126944473  linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
126963417  5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
126952008  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126950415  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126930448  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126947562  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126959042  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
126958548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126935530  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
126942604  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126955333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126963646  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126951422  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126935723  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126942881  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126943523  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126937751  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126949943  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126942836  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126939573  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126944893  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126949942  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126939894  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126942437  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
126937647  cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
126963591  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126960038  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
126957570  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
126936897  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
126944576  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
126930739  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
126961592  calmodulin-1-like [KO:K02183]
126962311  calmodulin-like protein 5 [KO:K02183]
126962328  calmodulin-like protein 3 [KO:K02183]
126943484  calmodulin-3 isoform X1 [KO:K02183]
126958173  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
126951481  calmodulin-1-like [KO:K02183]
126934255  calmodulin-2 [KO:K02183]
126952282  calmodulin-like protein 6 [KO:K02183]
126959699  calmodulin-1 isoform X1 [KO:K02183]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126948197  ras-related protein M-Ras isoform X1 [KO:K07831]
126943140  ras-related protein R-Ras [KO:K07829]
126936606  ras-related protein R-Ras2 [KO:K07830]
126938974  neurofibromin isoform X1 [KO:K08052]
126957382  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
126947414  ras GTPase-activating protein 2 isoform X1 [KO:K08053]
126940824  ras GTPase-activating protein 3 isoform X1 [KO:K12380]
126950343  ras GTPase-activating protein 4B isoform X1 [KO:K17630]
126952711  ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
126931436  rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
126940701  ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
126942186  RAS protein activator like-3 [KO:K17634]
126948713  ras association domain-containing protein 1 isoform X1 [KO:K09850]
126938008  ras association domain-containing protein 5 isoform X1 [KO:K08015]
126963827  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
126951691  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126963767  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126939124  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126935687  serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
126947966  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126946371  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
126942009  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
126929039  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
126959816  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
126948741  transforming protein RhoA [KO:K04513]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126964283  bcl-2-like protein 1 isoform X1 [KO:K04570]
126946179  forkhead box protein O4 [KO:K12358]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126959160  ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
126929216  ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
126964172  ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
126929778  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929779  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929780  ral-GDS-related protein-like [KO:K08732]
126936899  ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
126964069  ral-GDS-related protein-like [KO:K08732]
126947346  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929238  ral-GDS-related protein-like [KO:K08732]
126929502  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929506  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929550  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929580  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929584  ral-GDS-related protein-like [KO:K08732]
126929625  ral-GDS-related protein-like [KO:K08732]
126940091  ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
126952728  ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
126950131  ras-related protein Ral-A [KO:K07834]
126933156  ras-related protein Ral-B [KO:K07835]
126939667  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
126948354  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
126953312  exocyst complex component 2 isoform X1 [KO:K17637]
126930857  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
126933598  proto-oncogene c-Rel isoform X1 [KO:K09254]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126941117  ralA-binding protein 1 isoform X1 [KO:K08773]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126952445  afadin isoform X1 [KO:K05702]
126962830  leucine-rich repeat protein SHOC-2 [KO:K19613]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126947744  phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
126930703  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126954950  group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126962529  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
126956237  group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126956382  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126956433  putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126956447  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
126956452  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126956471  phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
126944542  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126963932  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126943448  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
126950100  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126959281  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126959808  cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
126959810  cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
126959812  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
126963704  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
126935619  phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
126935620  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
126944416  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1-like [KO:K04375]
126945587  ETS domain-containing protein Elk-1 [KO:K04375]
126934689  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1-like [KO:K04375]
126936554  protein C-ets-1 isoform X1 [KO:K02678]
126950682  protein C-ets-2 [KO:K21932]
126931455  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
126938720  kinase suppressor of Ras 1 isoform X1 [KO:K14958]
126930606  kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
126950012  rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
126930173  ras-related protein Rap-1A [KO:K04353]
126930986  ras-related protein Rap-1b [KO:K07836]
126937705  ras-related protein Rap-1b-like [KO:K07836]
126962017  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126935341  ras and Rab interactor 1 [KO:K17638]
126936893  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
126950153  tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
126945267  ras-related protein Rab-5A-like [KO:K07887]
126946715  ras-related protein Rab-5A [KO:K07887]
126931223  ras-related protein Rab-5B [KO:K07888]
126962471  ras-related protein Rab-5C-like [KO:K07889]
126938528  ras-related protein Rab-5C [KO:K07889]
126958541  ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
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pathway
mthb04010  MAPK signaling pathway
mthb04015  Rap1 signaling pathway
mthb04020  Calcium signaling pathway
mthb04144  Endocytosis
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mthb04660  T cell receptor signaling pathway
mthb04720  Long-term potentiation
mthb04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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