KEGG   PATHWAY: npo05169
Entry
npo05169                    Pathway                                
Name
Epstein-Barr virus infection - Nyctereutes procyonoides (raccoon dog)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
npo05169  Epstein-Barr virus infection
npo05169

Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129505911  complement receptor type 1-like [KO:K04012]
129519054  CD19; B-lymphocyte antigen CD19 [KO:K06465]
129512314  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
129512546  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
129512547  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
129512797  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
129512799  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
129513026  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
129513027  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
129513028  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129513030  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
129516767  TLR2; toll-like receptor 2 [KO:K10159]
129506934  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129505651  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129518585  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
129494142  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
129511324  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
129499952  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129512811  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129493669  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129515857  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129517602  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129499457  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129521190  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129503049  RELA; transcription factor p65 isoform X1 [KO:K04735]
129512779  TNF; tumor necrosis factor [KO:K03156]
129502880  IL6; interleukin-6 [KO:K05405]
129494755  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
129522891  AP5S1; AP-5 complex subunit sigma-1 isoform X1 [KO:K12648]
129496135  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
129511757  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129515179  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
129494159  IRF7; interferon regulatory factor 7 [KO:K09447]
129499930  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
129494481  interferon alpha-1/2-like [KO:K05414]
129494482  interferon alpha-1/2-like [KO:K05414]
129494483  interferon alpha-1/2-like [KO:K05414]
129494485  interferon alpha-1/2-like [KO:K05414]
129494486  interferon alpha-1/2-like [KO:K05414]
129494487  interferon alpha-1/2 [KO:K05414]
129494488  interferon alpha-1/2 [KO:K05414]
129494489  interferon alpha-1/2 [KO:K05414]
129494490  interferon alpha-1/2 [KO:K05414]
129494491  interferon alpha-1/2 [KO:K05414]
129494492  interferon alpha-1/2 [KO:K05414]
129494493  interferon alpha-1/2 [KO:K05414]
129494495  interferon alpha-1/2 [KO:K05414]
129494496  interferon alpha-1/2 [KO:K05414]
129494497  interferon alpha-1/2 [KO:K05414]
129494498  interferon alpha-1/2 [KO:K05414]
129494499  interferon alpha-1/2 [KO:K05414]
129494500  interferon alpha-1/2 [KO:K05414]
129494696  interferon alpha-1/2-like [KO:K05414]
129494819  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129495209  interferon alpha-3-like [KO:K05414]
129495280  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
129495282  interferon alpha-1/2 [KO:K05414]
129494739  IFNB1; interferon beta [KO:K05415]
129502186  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
129502075  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
129497055  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129521932  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
129522804  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
129511791  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
129499451  IRF9; interferon regulatory factor 9 [KO:K04693]
129510944  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
129508323  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
129508337  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
129501825  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
129497315  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
129508172  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129503100  FADD; FAS-associated death domain protein [KO:K02373]
129523021  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129503380  BID; BH3-interacting domain death agonist [KO:K04726]
129510903  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
129495480  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129514527  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129501028  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
129513046  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
129502969  cytochrome c [KO:K08738]
129506647  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
129515281  cytochrome c-like [KO:K08738]
129518214  cytochrome c-like [KO:K08738]
129516890  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129513406  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129503548  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
129514977  uncharacterized protein LOC129514977 [KO:K10784]
129497000  T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
129497001  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
129497002  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
129508837  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
129494062  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
129496104  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
129501026  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
129496164  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
129503039  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
129511360  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
129498487  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
129493603  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
129505415  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
129515416  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
129512868  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
129515240  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
129522308  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
129497533  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
129494302  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
129501518  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
129498701  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
129499914  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
129498625  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
129504638  26S proteasome complex subunit SEM1-like [KO:K10881]
129498270  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
129513013  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
129512879  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
129512984  TAPBP; tapasin isoform X1 [KO:K08058]
129504167  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
129522085  CALR; calreticulin [KO:K08057]
129499223  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
129512639  DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
129512971  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
129513138  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
129513147  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
129504074  B2M; beta-2-microglobulin [KO:K08055]
129496121  SNW1; SNW domain-containing protein 1 [KO:K06063]
129497366  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
129506300  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
129512681  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
129513704  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
129507743  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
129493959  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
129509666  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
129498553  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
129510316  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
129522224  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
129507385  HES1; transcription factor HES-1 [KO:K06054]
129521962  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
129514205  RUNX3; runt-related transcription factor 3 [KO:K09279]
129502657  MYC; myc proto-oncogene protein [KO:K04377]
129519302  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
129511628  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129497070  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
129512989  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129500388  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
129519073  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
129521889  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
129499055  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
129521032  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
129505849  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
129496789  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129498637  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129507069  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129513452  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129520803  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129522073  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129508823  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129495892  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129499851  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129517633  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129514778  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129512996  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
129500525  RELB; transcription factor RelB [KO:K09253]
129493939  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
129497106  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
129499646  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
129513074  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
129497178  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
129521885  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129494670  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129501796  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129522825  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129515072  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
129507824  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
129497110  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129508745  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129511619  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129511620  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512956  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512957  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129497811  JUN; transcription factor Jun [KO:K04448]
129493930  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
129507029  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
129513135  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
129521609  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
129494205  CD44; LOW QUALITY PROTEIN: CD44 antigen [KO:K06256]
129520158  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
129501449  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
129522410  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
129504611  LOW QUALITY PROTEIN: vimentin-like [KO:K07606]
129514006  VIM; vimentin [KO:K07606]
129509287  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
129521365  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
129506479  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
129505366  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
129499651  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
129506290  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
129519689  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129518807  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
129493849  BLNK; B-cell linker protein isoform X1 [KO:K07371]
129497753  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129509822  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
129517176  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
129502968  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129503406  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129512587  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
129511485  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129498092  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
129504315  CCNA2; cyclin-A2 [KO:K06627]
129504591  CCNA1; cyclin-A1 [KO:K06627]
129501012  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
129495669  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
129497562  G1/S-specific cyclin-E1-like [KO:K06626]
129511299  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
129516428  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
129496621  E2F1; transcription factor E2F1 [KO:K17454]
129514246  E2F2; transcription factor E2F2 [KO:K09389]
129507839  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
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Reference
PMID:21429244
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Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
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Reference
PMID:28408983
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Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
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Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
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Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
npo03050  Proteasome
npo04010  MAPK signaling pathway
npo04020  Calcium signaling pathway
npo04064  NF-kappa B signaling pathway
npo04110  Cell cycle
npo04115  p53 signaling pathway
npo04210  Apoptosis
npo04612  Antigen processing and presentation
npo04620  Toll-like receptor signaling pathway
npo04622  RIG-I-like receptor signaling pathway
npo04630  JAK-STAT signaling pathway
npo04662  B cell receptor signaling pathway
KO pathway
ko05169   
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