KEGG   PATHWAY: oga04810
Entry
oga04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Otolemur garnettii (small-eared galago)
Class
Cellular Processes; Cell motility
Pathway map
oga04810  Regulation of actin cytoskeleton
oga04810

Other DBs
GO: 0030036
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100945428  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100942103  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100954954  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100946548  CXCL12; stromal cell-derived factor 1 [KO:K10031]
100945275  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100959798  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100940909  F2R; proteinase-activated receptor 1 [KO:K03914]
100958310  INS; insulin isoform X1 [KO:K04526]
100959686  EGF; pro-epidermal growth factor [KO:K04357]
100966077  FGF1; fibroblast growth factor 1 [KO:K18496]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100961245  FGF6; fibroblast growth factor 6 [KO:K04358]
100962391  FGF9; fibroblast growth factor 9 [KO:K04358]
100964809  FGF20; fibroblast growth factor 20 [KO:K04358]
100958629  FGF4; fibroblast growth factor 4 [KO:K04358]
100954515  FGF10; fibroblast growth factor 10 [KO:K04358]
100953298  FGF16; fibroblast growth factor 16 [KO:K04358]
100960938  FGF3; fibroblast growth factor 3 [KO:K04358]
100958585  FGF22; fibroblast growth factor 22 [KO:K04358]
100942388  FGF5; fibroblast growth factor 5 [KO:K04358]
100945380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100948029  FGF18; fibroblast growth factor 18 [KO:K04358]
100947419  FGF7; fibroblast growth factor 7 [KO:K04358]
100940920  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
100961253  FGF19; fibroblast growth factor 19 [KO:K22603]
100947735  FGF21; fibroblast growth factor 21 [KO:K22429]
100958098  FGF23; fibroblast growth factor 23 [KO:K22428]
100944643  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100943395  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100962660  PDGFD; platelet-derived growth factor D [KO:K05450]
100964580  PDGFC; platelet-derived growth factor C [KO:K05450]
100967004  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100960708  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100952813  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100962219  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100957667  FGFR4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100961338  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100951606  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100948167  FN1; fibronectin isoform X2 [KO:K05717]
100940990  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
100949511  ITGA2; integrin alpha-2 [KO:K06481]
100951652  ITGA2B; integrin alpha-IIb [KO:K06476]
100950802  ITGA3; integrin alpha-3 [KO:K06482]
100955762  ITGA4; integrin alpha-4 [KO:K06483]
100951353  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100962528  ITGA6; integrin alpha-6 [KO:K06485]
100961952  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100952704  ITGA8; integrin alpha-8 [KO:K06584]
100945936  ITGA9; integrin alpha-9 [KO:K06585]
100955879  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100965465  ITGA11; integrin alpha-11 [KO:K06587]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100963323  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100950220  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100949901  ITGAX; integrin alpha-X [KO:K06462]
100949585  ITGAD; integrin alpha-D [KO:K06594]
100964721  ITGAE; integrin alpha-E [KO:K06524]
100955745  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100944658  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
100965552  LOW QUALITY PROTEIN: integrin beta-2-like [KO:K06464]
100949430  ITGB3; integrin beta-3 [KO:K06493]
100953017  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100941684  ITGB5; integrin beta-5 [KO:K06588]
100950946  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100963518  ITGB7; integrin beta-7 [KO:K06590]
100960579  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100952099  KNG1; kininogen-1 isoform X5 [KO:K03898]
100963177  BDKRB1; B1 bradykinin receptor [KO:K03915]
100962856  BDKRB2; B2 bradykinin receptor [KO:K03916]
100942748  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100952938  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100958960  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100957661  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
100941460  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100961815  C5; complement C5 isoform X1 [KO:K03994]
100965204  C6; complement component C6 [KO:K03995]
100948835  C7; complement component C7 [KO:K03996]
100963210  C8A; complement component C8 alpha chain [KO:K03997]
100963531  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
100950742  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
100962993  C9; complement component C9 [KO:K04000]
100956403  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100963709  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100950477  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111727847  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100941330  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
100952433  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
100962373  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
100955552  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100958636  CRK; adapter molecule crk isoform X1 [KO:K04438]
100951208  CRKL; crk-like protein [KO:K04438]
100963112  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
100941865  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100948262  RRAS; ras-related protein R-Ras [KO:K07829]
100958945  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100967191  MRAS; ras-related protein M-Ras [KO:K07831]
100964965  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100963265  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100947275  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100950628  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100950232  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100947929  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100955336  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100946010  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100953991  RGCC; regulator of cell cycle RGCC [KO:K26108]
100951083  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
100957349  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100943600  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100954771  RHOA; transforming protein RhoA [KO:K04513]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100957182  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100948274  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100947706  cell division control protein 42 homolog [KO:K04393]
100950992  CDC42; cell division control protein 42 homolog [KO:K04393]
100950236  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100967098  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100946163  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
100951847  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
100941945  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100951027  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100951458  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
100949716  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
100942105  GIT1; ARF GTPase-activating protein GIT1 isoform X2 [KO:K05737]
100964845  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100953342  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
100945351  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100954101  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100955570  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100941909  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100960152  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100945379  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
100955707  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100963170  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
100954524  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105888131  MYL5; myosin light chain 5 [KO:K12753]
100954531  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
100940607  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100957861  MYL10; myosin regulatory light chain 10 [KO:K12756]
100948786  myosin regulatory light polypeptide 9-like [KO:K12757]
100948059  myosin regulatory light chain 12B [KO:K12757]
100962371  myosin regulatory light polypeptide 9-like isoform X1 [KO:K12757]
100965853  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100963041  MYH9; myosin-9 [KO:K10352]
100942664  MYH14; myosin-14 isoform X2 [KO:K10352]
100959225  MYH11; myosin-11 isoform X2 [KO:K10352]
100952189  MYH10; myosin-10 isoform X2 [KO:K10352]
100950559  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
100942245  DIAPH2; protein diaphanous homolog 2 isoform X2 [KO:K05741]
100948977  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100940352  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
100950519  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100960689  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
100957895  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100956911  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
100960450  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
100943215  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
100961500  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4 [KO:K00921] [EC:2.7.1.150]
100945796  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
100944489  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
100959122  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
100954799  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3 [KO:K05627]
100943336  ENAH; protein enabled homolog isoform X1 [KO:K05746]
100966250  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
100951401  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
100956957  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
100966722  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
100951983  NCKAP1L; nck-associated protein 1-like [KO:K05750]
100952415  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
100943306  ABI2; abl interactor 2 [KO:K05751]
100952589  BRK1; protein BRICK1 [KO:K05752]
100957887  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
100946192  ACTR2; actin-related protein 2 [KO:K17260]
100948324  LOW QUALITY PROTEIN: actin-related protein 3 [KO:K18584]
100948421  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100953817  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100954135  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100953949  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100950633  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100950493  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100945228  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100966429  actin, cytoplasmic 1-like [KO:K05692]
100953854  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100960800  ACTB; actin, cytoplasmic 1 [KO:K05692]
100953981  PFN4; profilin-4 [KO:K05759]
100964647  PFN2; profilin-2 isoform X1 [KO:K05759]
100960556  PFN3; profilin-3 [KO:K05759]
100961857  PFN1; profilin-1 [KO:K05759]
100941877  PXN; paxillin isoform X1 [KO:K05760]
100955030  EZR; ezrin isoform X1 [KO:K08007]
100956512  RDX; radixin isoform X1 [KO:K05762]
100965374  MSN; moesin isoform X1 [KO:K05763]
111723228  thymosin beta-4-like [KO:K05764]
100953997  thymosin beta-4 [KO:K05764]
100966053  TMSB4X; thymosin beta-4 [KO:K05764]
100960952  uncharacterized protein LOC100960952 [KO:K05764]
100960940  CFL1; cofilin-1 [KO:K05765]
100962991  CFL2; cofilin-2 [KO:K05765]
100941171  SSH2; protein phosphatase Slingshot homolog 2 isoform X4 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100943375  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100957523  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100941404  VCL; vinculin isoform X1 [KO:K05700]
100959408  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100955206  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
100945596  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
100960968  GSN; gelsolin isoform X1 [KO:K05768]
100942968  SCIN; adseverin [KO:K05768]
100964271  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100961668  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100950293  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100966348  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100965320  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
100943681  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
oga04010  MAPK signaling pathway
oga04510  Focal adhesion
oga04520  Adherens junction
KO pathway
ko04810   
LinkDB

DBGET integrated database retrieval system