KEGG   PATHWAY: onl05168
Entry
onl05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Oreochromis niloticus (Nile tilapia)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
onl05168  Herpes simplex virus 1 infection
onl05168

Disease
H00365  Herpes simplex virus infection
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100534438  casp3a; caspase 3, apoptosis-related cysteine peptidase a [KO:K02187] [EC:3.4.22.56]
100534578  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
100628564  [KO:K06752]
100689711  [KO:K06751]
100689714  [KO:K05152]
100689853  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100689877  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X3 [KO:K04427] [EC:2.7.11.25]
100690040  pou2f2; POU domain, class 2, transcription factor 2 isoform X2 [KO:K09364]
100690332  [KO:K05704] [EC:2.7.10.2]
100690392  [KO:K06752]
100690473  [KO:K02649]
100690512  ifngr1l; interferon gamma receptor 1-like precursor [KO:K05132]
100690589  [KO:K06751]
100690666  [KO:K06752]
100690671  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100690725  srsf6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
100690759  [KO:K05414]
100690823  [KO:K12893]
100690857  [KO:K05425]
100690863  [KO:K06751]
100690923  [KO:K12893]
100691025  [KO:K05414]
100691089  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
100691149  [KO:K06752]
100691290  [KO:K05414]
100691322  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100691561  [KO:K05414]
100691607  [KO:K16195] [EC:2.7.11.1]
100691647  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100691651  [KO:K03990]
100691666  pou2f1; POU domain, class 2, transcription factor 1 isoform X8 [KO:K09364]
100691675  eif2b4; translation initiation factor eIF-2B subunit delta [KO:K03680]
100691708  [KO:K04734]
100691860  [KO:K04456] [EC:2.7.11.1]
100691882  [KO:K06269] [EC:3.1.3.16]
100691933  [KO:K06751]
100691970  orni-dba; mamu class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100692000  [KO:K06752]
100692017  [KO:K04456] [EC:2.7.11.1]
100692041  [KO:K08738]
100692059  srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
100692065  [KO:K05131]
100692146  [KO:K15409] [EC:2.7.11.1]
100692155  [KO:K06269] [EC:3.1.3.16]
100692160  [KO:K07205]
100692170  [KO:K06269] [EC:3.1.3.16]
100692186  [KO:K03990]
100692201  [KO:K06751]
100692238  [KO:K06752]
100692325  [KO:K12890]
100692332  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100692471  [KO:K06751]
100692508  [KO:K06752]
100692549  [KO:K06752]
100692564  [KO:K04447] [EC:2.7.10.2]
100692677  [KO:K05704] [EC:2.7.10.2]
100692869  [KO:K04467] [EC:2.7.11.10]
100693013  [KO:K06751]
100693282  [KO:K04519]
100693481  [KO:K06752]
100693657  [KO:K02649]
100693670  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100693748  [KO:K05406]
100693973  [KO:K08738]
100694547  tlr2; toll-like receptor 2 [KO:K10159]
100694816  hcfc2; host cell factor 2 isoform X1 [KO:K27390]
100695154  pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
100695205  [KO:K12891]
100695399  [KO:K05425]
100695417  [KO:K02187] [EC:3.4.22.56]
100695544  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100695550  [KO:K14966]
100695678  [KO:K02187] [EC:3.4.22.56]
100695830  srsf5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
100696216  tsc2; tuberin isoform X2 [KO:K07207]
100696271  [KO:K08738]
100696359  stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
100696424  [KO:K05414]
100696509  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100696572  [KO:K05654] [EC:7.4.2.14]
100696606  [KO:K06484]
100696765  [KO:K06751]
100696887  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100697006  tmem173; stimulator of interferon genes protein [KO:K12654]
100697176  [KO:K09849]
100697298  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
100697308  [KO:K03173] [EC:2.3.2.27]
100697318  [KO:K06752]
100697370  [KO:K08055]
100697746  [KO:K03156]
100697852  [KO:K06751]
100697902  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100698072  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100698118  [KO:K06751]
100698148  [KO:K04467] [EC:2.7.11.10]
100698172  [KO:K08055]
100698385  [KO:K06751]
100698679  [KO:K05654] [EC:7.4.2.14]
100698680  [KO:K06752]
100699073  [KO:K06751]
100699091  [KO:K06752]
100699105  [KO:K06493]
100699213  rheb; GTP-binding protein Rheb [KO:K07208]
100699341  [KO:K06751]
100699614  [KO:K06751]
100699631  [KO:K06751]
100699673  nectin1; nectin-1 isoform X1 [KO:K06081]
100699877  [KO:K04427] [EC:2.7.11.25]
100699927  [KO:K04726]
100700134  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100700219  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100700270  [KO:K04570]
100700343  [KO:K16195] [EC:2.7.11.1]
100700382  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100700419  [KO:K06751]
100700534  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100700918  [KO:K07293] [EC:3.1.3.48]
100700970  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
100700974  [KO:K03990]
100700986  [KO:K07208]
100701175  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100701239  [KO:K05842]
100701242  [KO:K06752]
100701247  [KO:K08058]
100701404  [KO:K05406]
100701465  srpk1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
100701504  [KO:K06751]
100701534  [KO:K11221]
100701636  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
100701693  [KO:K06752]
100701791  [KO:K06751]
100701969  [KO:K06752]
100701975  [KO:K06752]
100701980  [KO:K08057]
100702092  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100702139  [KO:K04398] [EC:3.4.22.61]
100702187  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
100702193  [KO:K04456] [EC:2.7.11.1]
100702234  [KO:K06752]
100702241  [KO:K06751]
100702327  [KO:K06751]
100702554  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
100702578  traf3; TNF receptor-associated factor 3 [KO:K03174]
100702587  p53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100702595  [KO:K06751]
100702676  [KO:K04398] [EC:3.4.22.61]
100702693  [KO:K06752]
100702826  [KO:K06752]
100702954  [KO:K05411]
100703536  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
100703551  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100703581  [KO:K06752]
100703629  [KO:K05401]
100703662  [KO:K14966]
100703664  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100703705  [KO:K05152]
100703748  c5; complement C5 [KO:K03994]
100703853  [KO:K06752]
100703882  cd40lg; CD40 ligand [KO:K04389]
100703930  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100703933  [KO:K06751]
100703972  [KO:K05152]
100704151  nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
100704232  [KO:K04696]
100704307  [KO:K06751]
100704382  bcl2l1; bcl-2-like protein 1 [KO:K04570]
100704472  [KO:K06751]
100704479  [KO:K00922] [EC:2.7.1.153]
100704495  [KO:K07206]
100704524  [KO:K12890]
100704575  [KO:K06751]
100704618  [KO:K08057]
100704886  [KO:K05414]
100704901  [KO:K07205]
100705065  [KO:K12890]
100705233  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100705328  [KO:K16060]
100705515  [KO:K06752]
100705695  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
100705827  [KO:K04389]
100705849  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100705892  [KO:K07206]
100705953  [KO:K10159]
100706040  [KO:K06752]
100706164  [KO:K02159]
100706192  irf7; interferon regulatory factor 7 [KO:K09447]
100706412  [KO:K05414]
100706487  tapbpl; tapasin-related protein [KO:K28445]
100706609  [KO:K00922] [EC:2.7.1.153]
100706685  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100706746  [KO:K05425]
100706881  [KO:K06269] [EC:3.1.3.16]
100706963  fadd; FAS-associated death domain protein [KO:K02373]
100707066  [KO:K04519]
100707309  [KO:K21123]
100707310  alyref; THO complex subunit 4 [KO:K12881]
100707440  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100707443  [KO:K04519]
100707450  [KO:K06081]
100707620  [KO:K12893]
100707658  [KO:K06531]
100707676  rela; transcription factor p65 isoform X1 [KO:K04735]
100707709  [KO:K08056] [EC:5.3.4.1]
100707861  [KO:K00922] [EC:2.7.1.153]
100707971  [KO:K04456] [EC:2.7.11.1]
100707974  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100708203  [KO:K09364]
100708205  [KO:K06752]
100708273  [KO:K02649]
100708418  cfp; properdin [KO:K15412]
100708442  [KO:K03173] [EC:2.3.2.27]
100708586  [KO:K06751]
100708604  itgb3; integrin beta-3 [KO:K06493]
100708663  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
100708809  srsf7; serine/arginine-rich splicing factor 7 isoform X2 [KO:K12896]
100708941  [KO:K05152]
100709109  [KO:K06752]
100709212  [KO:K05152]
100709252  [KO:K12881]
100709279  [KO:K06752]
100709378  [KO:K06752]
100709475  [KO:K05152]
100709564  [KO:K11220]
100709571  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
100709634  cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
100709656  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
100709733  [KO:K02649]
100710015  [KO:K02649]
100710044  [KO:K04447] [EC:2.7.10.2]
100710179  [KO:K06752]
100710185  [KO:K06752]
100710191  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
100710202  [KO:K06752]
100710322  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
100710640  [KO:K12891]
100710971  [KO:K06752]
100711084  [KO:K06751]
100711353  [KO:K06751]
100711756  [KO:K12892]
100711757  [KO:K08057]
100711853  [KO:K06531]
100711888  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100711894  [KO:K06751]
100711901  [KO:K06752]
100711983  [KO:K06484]
100712130  bad; bcl2-associated agonist of cell death [KO:K02158]
100712435  [KO:K06751]
100712493  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
102075777  [KO:K06751]
102076284  [KO:K10159]
102076776  [KO:K06751]
102076916  tlr2; toll-like receptor 2 [KO:K10159]
102076922  [KO:K06751]
102077009  [KO:K10159]
102077017  [KO:K05405]
102077098  [KO:K06751]
102077830  [KO:K06081]
102077886  [KO:K06081]
102077979  [KO:K06081]
102078106  [KO:K17834] [EC:2.7.7.86]
102078547  [KO:K06081]
102078673  [KO:K05131]
102078975  [KO:K12794]
102078978  [KO:K06751]
102078979  [KO:K06081]
102079144  [KO:K06751]
102079182  [KO:K06081]
102079249  [KO:K05152]
102079353  [KO:K02161]
102079388  [KO:K06751]
102079645  [KO:K06081]
102079913  [KO:K04398] [EC:3.4.22.61]
102079940  [KO:K06081]
102079979  [KO:K06081]
102080174  [KO:K06081]
102080229  [KO:K06751]
102080465  [KO:K06081]
102080840  [KO:K03158]
102081105  [KO:K03156]
102081538  ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
102082145  [KO:K05477]
102082262  [KO:K06752]
102082498  [KO:K06752]
102082670  [KO:K05152]
102082760  [KO:K05477]
102082902  [KO:K06751]
102083126  [KO:K04390]
102083274  [KO:K05414]
106096465  [KO:K06751]
106096967  [KO:K06752]
106097853  [KO:K17834] [EC:2.7.7.86]
106097998  [KO:K02159]
106098650  [KO:K06752]
106098985  [KO:K06751]
109194176  [KO:K06752]
109194206  [KO:K04398] [EC:3.4.22.61]
109194321  [KO:K06081]
109194340  [KO:K06752]
109194343  [KO:K06752]
109194454  [KO:K06752]
109194531  [KO:K06751]
109194569  [KO:K06751]
109194594  [KO:K06751]
109195038  [KO:K06752]
109195039  [KO:K06752]
109196021  [KO:K06269] [EC:3.1.3.16]
109196111  [KO:K06081]
109196360  [KO:K06751]
109196367  [KO:K06751]
109196370  [KO:K06751]
109196374  [KO:K06751]
109196375  [KO:K06751]
109196430  [KO:K06752]
109196810  [KO:K06751]
109196813  [KO:K06751]
109198656  [KO:K06751]
109199964  [KO:K06751]
109200123  [KO:K06751]
109200342  [KO:K06751]
109200348  [KO:K06751]
109200724  [KO:K06751]
109201079  [KO:K06751]
109201613  [KO:K06752]
109201890  [KO:K02159]
109201948  [KO:K06752]
109201950  [KO:K06752]
109202487  [KO:K10159]
109202867  [KO:K06752]
109203135  [KO:K05414]
109203155  [KO:K05414]
109203208  [KO:K05414]
109203209  [KO:K05414]
109203210  [KO:K05414]
109203266  [KO:K05414]
109203267  [KO:K05414]
109204230  [KO:K06752]
109204231  [KO:K06752]
109204294  [KO:K06752]
109204785  [KO:K17834] [EC:2.7.7.86]
112841688  [KO:K06751]
112841703  [KO:K06751]
112841710  [KO:K06751]
112841720  [KO:K05414]
112841757  [KO:K06752]
112843554  [KO:K06751]
112844122  [KO:K06081]
112846215  [KO:K06751]
112847709  [KO:K05414]
112847710  [KO:K05414]
112848122  [KO:K06081]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
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PMID:17229694
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Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
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Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:23 (2016)
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PMID:15163721
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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PMID:21146386
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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PMID:12960333
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J Immunol 171:3075-83 (2003)
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PMID:25798530
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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PMID:28468873
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Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
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PMID:18508584
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
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PMID:15078920
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Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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PMID:27154074
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Yu X, He S
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
onl03040  Spliceosome
onl03050  Proteasome
onl04115  p53 signaling pathway
onl04210  Apoptosis
onl04620  Toll-like receptor signaling pathway
onl04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

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