KEGG   PATHWAY: pcoq05169
Entry
pcoq05169                   Pathway                                
Name
Epstein-Barr virus infection - Propithecus coquereli (Coquerel's sifaka)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoq05169  Epstein-Barr virus infection
pcoq05169

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105805844  CR2; complement receptor type 2 [KO:K04012]
105805962  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105824372  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
105824381  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105824383  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
105824384  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
105824385  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105824386  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
105824388  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105824389  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
105817835  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
105817913  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
105810148  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
105811134  TLR2; toll-like receptor 2 [KO:K10159]
105805211  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105805561  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
105824543  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105814571  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105805175  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105819344  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105805315  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105821530  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105822445  IL6; interleukin-6 [KO:K05405]
105819684  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
105806202  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
105812625  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105821217  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105816570  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105809375  IRF3; interferon regulatory factor 3 [KO:K05411]
105827001  interferon alpha-5-like [KO:K05414]
105827006  IFNB1; interferon beta [KO:K05415]
105820771  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105820833  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105806352  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105807810  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
105813290  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105817095  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105812737  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
105818017  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105825595  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
105815749  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
105820926  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
105822691  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105827473  FADD; FAS-associated death domain protein [KO:K02373]
105819477  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105815816  BID; BH3-interacting domain death agonist [KO:K04726]
105808300  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105811149  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105821684  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105812509  cytochrome c-like [KO:K08738]
105807375  cytochrome c, somatic [KO:K08738]
105815609  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105810555  cytochrome c-like [KO:K08738]
105826075  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105814175  uncharacterized protein LOC105814175 [KO:K10784]
105819243  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
105819211  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
105819245  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
105821153  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
105815191  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105820609  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
105825847  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105811066  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105823955  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
105807577  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105816719  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105824126  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105820430  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105813564  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105804976  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105823339  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105816545  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105821915  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105819542  PSMD14; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105817257  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
105820583  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105818541  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
105824378  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105824379  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
105821685  TAPBP; tapasin [KO:K08058]
105814384  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105806269  calreticulin-like [KO:K08057]
105807890  CALR; calreticulin [KO:K08057]
105817846  HLA class I histocompatibility antigen, B-8 alpha chain-like [KO:K06751]
105817910  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
105817268  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
105817288  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
105817290  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105817294  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
105814533  B2M; beta-2-microglobulin [KO:K08055]
105819865  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
105807261  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
105808587  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
105811004  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
105825641  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
105816275  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
105817493  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
105815517  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
105826253  RBPJ; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless [KO:K06053]
105821274  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
105808411  HES1; transcription factor HES-1 [KO:K06054]
105807771  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
105815712  RUNX3; runt-related transcription factor 3 [KO:K09279]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105813076  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
105812777  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105811966  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105817781  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105817934  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105811078  DDB2; DNA damage-binding protein 2 [KO:K10140]
105826550  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
105805435  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105824147  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105817529  RELB; transcription factor RelB [KO:K09253]
105824302  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
105823400  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105820573  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
105807439  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
105818077  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105807933  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105815999  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105818690  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105816051  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
105816099  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105824710  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105806347  JUN; transcription factor AP-1 [KO:K04448]
105818725  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
105818463  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
105813661  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
105807125  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105814589  CD44; CD44 antigen isoform X1 [KO:K06256]
105823192  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105821698  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
105807825  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105823669  VIM; vimentin [KO:K07606]
105815343  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
105818130  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
105820249  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105824094  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
105817784  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105821393  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105825941  Ig heavy chain Mem5-like [KO:K06856]
105822769  uncharacterized protein LOC105822769 [KO:K06856]
105814900  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
105818458  BLNK; B-cell linker protein [KO:K07371]
105813491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105814809  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
105819524  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105822622  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105807480  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105816738  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105820132  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105815267  CCNA2; cyclin-A2 [KO:K06627]
105810131  CCNA1; cyclin-A1 [KO:K06627]
105812544  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105809789  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105817322  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105813707  RB1; retinoblastoma-associated protein [KO:K06618]
105804948  E2F1; transcription factor E2F1 [KO:K17454]
105815699  E2F2; transcription factor E2F2 [KO:K09389]
105805737  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
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Related
pathway
pcoq03050  Proteasome
pcoq04010  MAPK signaling pathway
pcoq04020  Calcium signaling pathway
pcoq04064  NF-kappa B signaling pathway
pcoq04110  Cell cycle
pcoq04115  p53 signaling pathway
pcoq04210  Apoptosis
pcoq04612  Antigen processing and presentation
pcoq04620  Toll-like receptor signaling pathway
pcoq04622  RIG-I-like receptor signaling pathway
pcoq04630  JAK-STAT signaling pathway
pcoq04662  B cell receptor signaling pathway
KO pathway
ko05169   
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