KEGG   PATHWAY: pdic05160
Entry
pdic05160                   Pathway                                
Name
Hepatitis C - Phyllostomus discolor (pale spear-nosed bat)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pdic05160  Hepatitis C
pdic05160

Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114503660  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
114509733  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
114499572  CD81; CD81 antigen [KO:K06508]
114507862  CLDN12; claudin-12 [KO:K06087]
114495559  CLDN6; claudin-6 [KO:K06087]
114509671  CLDN5; claudin-5 [KO:K06087]
114505167  CLDN2; claudin-2 [KO:K06087]
114489859  claudin-34-like [KO:K06087]
114495568  CLDN9; claudin-9 [KO:K06087]
114490019  CLDN17; claudin-17 [KO:K06087]
114490063  CLDN8; claudin-8 [KO:K06087]
114497575  CLDN19; claudin-19 [KO:K06087]
114490518  CLDN11; claudin-11 [KO:K06087]
114490538  CLDN1; claudin-1 [KO:K06087]
114497964  CLDN3; claudin-3 [KO:K06087]
114491070  CLDN14; claudin-14 [KO:K06087]
114491100  CLDN16; claudin-16 isoform X1 [KO:K06087]
114498880  CLDN4; claudin-4 [KO:K06087]
114505147  CLDN15; claudin-15 [KO:K06087]
114505563  CLDN34; claudin-34 [KO:K06087]
114515005  CLDN7; claudin-7 [KO:K06087]
114500982  CLDN25; putative claudin-25 [KO:K06087]
114508381  claudin-22-like [KO:K06087]
114508676  CLDN10; claudin-10 isoform X2 [KO:K06087]
114494683  CLDN20; claudin-20 [KO:K06087]
114502013  CLDN18; claudin-18 isoform X1 [KO:K06087]
114508774  CLDN23; claudin-23 [KO:K06087]
114508848  putative claudin-24 [KO:K06087]
114504333  OCLN; occludin [KO:K06088]
114509361  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
114510048  2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
114491969  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
114512128  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
114511471  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
114507072  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
114492329  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
114513223  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114512155  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
114511489  IRF3; interferon regulatory factor 3 [KO:K05411]
114499187  IRF7; interferon regulatory factor 7 [KO:K09447]
114502765  interferon alpha-4-like [KO:K05414]
114502773  interferon alpha-4-like [KO:K05414]
114503306  interferon alpha-4-like [KO:K05414]
114490854  interferon alpha-4-like [KO:K05414]
114490401  interferon alpha-4-like [KO:K05414]
114512515  IFNB1; interferon beta [KO:K05415]
114514094  IFNG; interferon gamma [KO:K04687]
114508609  TLR3; toll-like receptor 3 [KO:K05401]
114502817  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
114500758  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114497608  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
114496345  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114508493  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114504586  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114492937  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
114492465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
114499888  RELA; transcription factor p65 [KO:K04735]
114495334  TNF; tumor necrosis factor isoform X1 [KO:K03156]
118499832  CXCL10; C-X-C motif chemokine 10 isoform X1 [KO:K12671]
114496089  LOW QUALITY PROTEIN: C-X-C motif chemokine 10 [KO:K12671]
114510023  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
114500200  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
114496093  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
114491717  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
114497067  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
114497068  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
114497069  interferon-induced protein with tetratricopeptide repeats 1B-like isoform X1 [KO:K14217]
114497848  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
114514509  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
114492274  EIF2S1; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
114500522  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
114502756  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114503090  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
114490062  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
114490003  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
114498103  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114502963  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
114494120  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
114513273  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
114492081  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
114490713  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
114490478  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
114498746  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
114511113  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
114499532  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
114502259  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114509286  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
114496579  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114492852  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
114492681  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
114508871  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114509174  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114493041  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
114492590  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114503433  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114499241  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114493440  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114499504  HRAS; GTPase HRas isoform X2 [KO:K02833]
114512682  KRAS; GTPase KRas isoform X1 [KO:K07827]
114489186  NRAS; GTPase NRas [KO:K07828]
114507230  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114501905  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
114504860  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
114499297  YWHAQ; 14-3-3 protein theta [KO:K16197]
114506321  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
114514896  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
114502329  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
114491537  YWHAG; 14-3-3 protein gamma [KO:K16198]
114509226  YWHAH; 14-3-3 protein eta [KO:K16198]
114491735  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
114503388  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114510156  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114496946  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114496100  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114502559  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
114501063  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114497407  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114490993  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114501452  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114510957  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114512350  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114492688  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114490568  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114502148  CTNNB1; catenin beta-1 [KO:K02105]
114499526  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
114494317  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114515376  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
114513129  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114512697  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114507954  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114508470  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
114506109  E2F1; transcription factor E2F1 [KO:K17454]
114496714  E2F2; transcription factor E2F2 [KO:K09389]
114496340  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
114514124  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114488446  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
114504307  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
114512032  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114497076  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
114489990  FADD; FAS-associated death domain protein [KO:K02373]
114494575  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
114508735  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114494605  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
114508724  BID; BH3-interacting domain death agonist [KO:K04726]
114510992  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
114494928  BAK1; LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer [KO:K14021]
114499664  cytochrome c-like [KO:K08738]
114506519  cytochrome c-like [KO:K08738]
114508100  cytochrome c [KO:K08738]
114506811  cytochrome c-like [KO:K08738]
114512815  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114497767  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
114503255  PSME3; proteasome activator complex subunit 3 [KO:K06698]
114507768  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
114513128  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
114499559  NR1H3; oxysterols receptor LXR-alpha isoform X3 [KO:K08536]
114500683  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114514698  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
pdic03320  PPAR signaling pathway
pdic04010  MAPK signaling pathway
pdic04144  Endocytosis
pdic04210  Apoptosis
pdic04514  Cell adhesion molecules
pdic04620  Toll-like receptor signaling pathway
pdic04622  RIG-I-like receptor signaling pathway
pdic04630  JAK-STAT signaling pathway
pdic04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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